3physiological imaging in tumor models
Báo cáo y học: " In vivo imaging approaches in animal models of rheumatoid arthritis" pot
... possible An alternative mode of imaging is the use of single photon imaging of γ-emitting isotopes like 11 1In or 99Tc Imaging of γ-emitting isotopes is referred to as single photon emission commuted ... No Dustin Table Summary of in vivo imaging methodologies Imaging mode Invasiveness Sensitivity, resolution, time scale Advantages Disadvantages Bioluminescence Anesthesia ~100 cells, mm, minutes ... rheumatologists interested in surgical procedures for in vivo imaging, there is a rich arsenal of procedures for imaging within almost all major organs of mice or rats Almost all were developed originally...
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báo cáo khoa học: "Application of Benchtop-magnetic resonance imaging in a nude mouse tumor model" ppt
... weekly For histological examination tumors were explanted, fixed in 4% formalin and embedded in paraffin Hematoxylin/Eosin staining of slices was performed according to standard protocols All ... non-invasive imaging technology plays a key role in preclinical in vivo evaluation of tumor therapies The development of a BT-MRI system for small animal imaging could lead to easy detection of tumor ... confined to the blood pool, therefore giving a longer time window for imaging in mice models A main advantage of MRI is the capability to characterize important tumor characteristics (e.g internal...
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Báo cáo sinh học: "Anti-tumor effects of a human VEGFR-2-based DNA vaccine in mouse models" pps
... 4T1 tumor cells in the right flank Treatments were initiated 13 days post -tumor inoculation (CT26 colon carcinoma model) or days posttumor inoculation (4T1 breast tumor model), at a time when tumor ... play a key role in tumor angiogenesis That blocking the VEGFVEGFR-2 pathway may inhibit tumor growth is exemplified in studies using neutralizing KDR/Flk-1 mAb[25], KDR/Flk-1 kinase inhibitors[26,27], ... Anti-cancer vaccines have been extensively studied in animal models and clinical trials Anti-cancer vaccine strategies have included immunization with whole -tumor cell vaccines, peptide vaccines, dendritic...
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Báo cáo sinh học: "Recombinant λ-phage nanobioparticles for tumor therapy in mice models" pdf
... Therapeutic antitumor assay To determine anti -tumor activity of recombinant λ-ZAP E7 phage could, we performed an in vivo tumor treatment experiment using a previously characterized E7expressing tumor ... days after inoculation Mice were monitored for evidence of tumor growth by palpation and inspection twice a week For determining of tumor volume, each individual tumor size was measured Line and ... http://www.gvt-journal.com/content/8/1/3 Figure Therapeutic vaccination against TC-1-induced tumors Mice were inoculated with × 105 TC-1 tumor into the right flank and then treated with recombinant λ-ZAP E7 phage, Wild λ-ZAP...
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Báo cáo y học: "Segment-orientated analysis of two-dimensional strain and strain rate as assessed by velocity vector imaging in patients with acute myocardial infarction"
... Int J Med Sci 2011, ability by the deformation indices two-dimensional strain (2DS) and strain rate (SR), might be an alternative approach in clinical routine Tissue Doppler Imaging (TDI) ... exclude segments in which the tracking failed (feasibility 71%) One could also criticize the intra-individual comparison instead of considering a control group In our opinion, as the infarct is a ... systolic strain rate [s-1]; ROI: Region of interest; TDI: Tissue Doppler Imaging; VVI: Velocity Vector Imaging Conflict of Interest The authors have declared that no conflict of interest exists...
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Báo cáo y học: "Rasburicase represents a new tool for hyperuricemia in tumor lysis syndrome and in gout Lisa Cammalleri and Mariano Malaguarnera"
... synthesis, and inosine that will be degraded into hypoxanthine and xanthine and finally into uric acid Hypoxanthine and guanine may enter in a salvage pathway, using hypoxanthine-guanine phosphoribosyltranferase ... The PEGylation consists in binding with a covalent link a protein (adenosine-deaminase, asparaginase, interferons, granulocyte colonystimulating factor, liposomal doxyrubicin) to poly(ethylene) ... conversion of hypoxanyhine into xanthine and this latter into uric acid During this reaction an active metabolite, deriving by enzymatic action on allopurinol, oxypurinol, inhibits xanthine oxidase and...
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Tài liệu Role of diffusion-weighted imaging in the diagnosis of gynecological diseases pdf
... Functional MR imaging of the female pelvis J Magn Reson Imaging 25:1101–1112 25 Koyama T, Tamai K, Togashi K (2006) Current status of body MR imaging: fast MR imaging and diffusionweighted imaging Int ... echo-planar MR imaging and ADC mapping in the differential diagnosis of ovarian cystic masses: usefulness of detecting keratinoid substances in mature cystic teratomas J Magn Reson Imaging 22:271–278 ... was useful in detecting pelvic lymph node metastasis in patients with cervical and uterine cancers However, the method combining size and relative ADC values was proposed by using a combination...
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Diagnostic Imaging in Oral and Maxillofacial Pathology docx
... maxillofacial region Especially in cysts/tumors differential diagnosis, it is recommended that combination of different imaging modalities www.intechopen.com Diagnostic Imaging in Oral and Maxillofacial ... Publisher InTech Published online 22, December, 2011 Published in print edition December, 2011 What we know about and with medical imaging has changed rapidly during the past decade, beginning with ... digital information management and research It is an invaluable tool for radiologists and imaging specialists, physicists and researchers interested in various aspects of imaging How to reference In...
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Báo cáo khoa học: "Combining Statistical and Knowledge-based Spoken Language Understanding in Conditional Models" pptx
... training algorithms for conditional models In most cases, CRF training is more accurate, however, perceptron training is much faster References Bahl, L., P Brown, et al 1986 Maximum mutual information ... CFG non-terminal NT, i.e., when words in two consecutive slots (“Washington” and “D.C.”) can also be covered by one single slot: ∀w, w1w2 | in the training data, w and w1w2 appears in front of ... label sequence until convergence In both perceptron and CRF training, we average the parameters over training iterations (Collins, 2002) Porting HMM/CFG Model to HCRFs In our first experiment, we...
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Báo cáo khoa học: Enzymatic features of the glucose metabolism in tumor cells ppt
... FEBS 2445 Tumor specific alterations in metabolism A Herling et al synthase kinase 3b, a multifunctional serine ⁄ threonine kinase that functions in diverse cellular processes including proliferation, ... phosphatidylinositol-3-kinase Akt and mitogen-activated protein kinase are candidate signaling pathways that mediate FASN expression through the sterol regulatory element binding protein 1c In breast ... rendering glucose uptake into tumor cells largely insulin-insensitive Abundance of GLUT1 correlates with aggressive tumor behavior such as high grade (poorly differentiated) invasion and Tumor...
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Báo cáo khoa học: Proteoglycans in health and disease: new concepts for heparanase function in tumor progression and metastasis pptx
... primary tumor [102] The possible involvement of heparanase in tumor selfseeding is supported by the timing of its induction during tumorigenesis and its prometastatic function Using the RIP-Tag2 tumor ... protein-coding genes contain introns that are removed in the nucleus by RNA splicing and are often alternatively spliced Alternative splicing increases the coding capacity of the genome, generating ... determinant behind its signaling capacity The existence of a C-terminus domain (C-domain) emerged from a prediction of the 3D structure of a single-chain heparanase enzyme [73] In this protein 3894...
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Báo cáo khoa học: Recent contributions of in vitro models to our understanding of hepatitis C virus life cycle pdf
... succeed in obtaining HCV infection in primary human hepatocytes, an existing model of hepatitis B virus infection was used to determine optimal infection conditions [39,40] Rumin et al pointed ... the poor binding inhibition achieved in the presence of mAbs directed against CD81 In contrast, heparin sulfate seemed to mediate this interaction [53] Taking advantage of this binding model, ... heterodimers in a virion-like conformation In vitro HCV infection models This model has essentially been used in two major fields of research: binding process and vaccination development Specific binding...
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Báo cáo khoa học: LRRK2 in Parkinson’s disease: in vivo models and approaches for understanding pathogenic roles pdf
... moesin, a protein that anchors the actin cytoskeleton to the plasma membrane [24] Although cytoskeleton proteins are known as frequent ‘contaminants’ in the process of searching binding proteins, ... the functional integrity of GbpC protein requires all subdomains in the core ‘LRCK’ sequence ROCO protein Pats1 was originally found in a genetic screen of cellular defect in cytokinesis of D discoideum ... domain of Pats1 interacted with myosin heavy chain, whereas the deletion of Pats1 caused an alteration in the localization of myosin heavy chain [17] Moreover, over-expression of the kinase domain...
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MEDICAL IMAGING IN CLINICAL PRACTICE_1 pot
... Tensor Imaging allowing changes in the developing brain, trauma, and white matter dis‐ ease Other techniques include arterial spin labeling useful in identifying perfusion changes in the brain Paediatric ... Gastrointestinal bleeding imaging The common causes of lower GI bleeding in adults include neoplasms, inflammatory bowel disease, diverticular disease and angiodysplasia The GI Imaging is a noninvasive ... Perspectives on Molecular Imaging for Tracking Stem Cell Therapy 63 Lingling Tong, Hui Zhao, Zuoxiang He and Zongjin Li Section Innovations in Medical Imaging Techniques Chapter Spin Average Supercompound...
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Báo cáo khoa học: "Tree Representations in Probabilistic Models for Extended Named Entities Detection" ppt
... discussed in the introduction and in section 2, since CRFs and models for parsing constitute the main issue in our work, we discuss some important models here Beyond the models for parsing discussed in ... results in an increasing number of labels to be learned by CRF This aspect is quite critical in CRF learning, as training time is exponential in the number of labels Indeed, the most complex models, ... Fillers of named entities should be, in principle, distinguished from any other filler, since they may be informative to discriminate entities Following this intuition, we designed two different...
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Báo cáo khoa học: Energy metabolism in tumor cells pot
... differences should be found in the mechanism proposed for decreasing oxidative phosphorylation in several tumor cell lines, not only in a selected one or two tumor cell lines Again, owing to the genetic ... suppressor, binds to HIF-1a and induces its degradation by the proteosome; in some aggressive tumors, the von Hippel-Lindau protein is mutated, thus becoming ineffective in promoting HIF-1a degradation ... respect to normal cells In tumor cells hexokinase II (HK-II) is over-expressed, increasing both the activity and the binding to the outer mitochondrial membrane, which in turn increases the HK-II...
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MEDICAL IMAGING IN CLINICAL PRACTICE docx
... Tensor Imaging allowing changes in the developing brain, trauma, and white matter dis‐ ease Other techniques include arterial spin labeling useful in identifying perfusion changes in the brain Paediatric ... Gastrointestinal bleeding imaging The common causes of lower GI bleeding in adults include neoplasms, inflammatory bowel disease, diverticular disease and angiodysplasia The GI Imaging is a noninvasive ... Perspectives on Molecular Imaging for Tracking Stem Cell Therapy 63 Lingling Tong, Hui Zhao, Zuoxiang He and Zongjin Li Section Innovations in Medical Imaging Techniques 81 Chapter Spin Average Supercompound...
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Research Directions in Tumor Angiogenesis Edited by Jianyuan Chai pptx
... MMP7, EphrinB2, interleu‐ kin receptor (IL-7R)[64] and Robo4[65] in vitro Robo4 expression in vivo is correspondingly under control of Sox7/18 activity in the mouse caudal vein, and in the intersegmental ... K A Rubina, E I Yurlova, V Yu Sysoeva, E V Semina, N I Kalinina, A A Poliakov, I N Mikhaylova, N V Andronova and H M Treshalina Chapter The Use of Artemisinin Compounds as Angiogenesis Inhibitors ... Torino, Italy), summarizes all the known ROS and dissects how they influence tumor angiogenesis The level of ROS in the tumor microenvironment can be a determining factor for the fate of a tumor...
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nmr imaging in chemical engineering
... NMR imaging This book does not aim to highlight who is leading the field in non-medical NMR imaging, but rather intends to convince many scientists and chemical engineers how cool NMR imaging ... Nuclear Magnetic Resonance Imaging in Chemical Engineering Forward The field of nuclear magnetic resonance imaging (NMRI) has seen extraordinary technical advances since the seminal demonstrations of ... NMR Imaging in Chemical Engineering Edited by Siegfried Stapf and Song-I Han NMR Imaging in Chemical Engineering Edited by Siegfried Stapf and Song-I Han...
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a first course in stochastic models - h. c. tijms
... it will be intuitively clear that the Poisson process has the following properties: (A) Independent increments: the numbers of arrivals occurring in disjoint intervals of time are independent ... which an arriving customer finds the system empty (ii) The discrete-time process {In , n = 0, 1, } with In denoting the inventory level at the beginning of the nth week in the (s, S) inventory ... epochs show a tendency to cluster Indeed this is confirmed by simulation experiments Clustering of points in Poisson processes is of interest in many applications, including risk analysis and telecommunication...
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