... regulator of calcineurin 1 (RCAN1) protein at Ser112 and Thr192. RCAN1 is also located in the DSCR. The phosphorylation of RCAN1 enhances RCAN1 binding to calcineurin, resulting in reduced NFAT ... favoring the development of genomic instability and tumor growth (Zhu et al. 2004). The inhibition of HDAC in combination with chemotherapy (doxorubicin) is currently assessed in phase I clinical ... carcinoma: DNA-profile, laminin-5 gamma2 chain and cyclin A expression as early markers for risk assessment. Scand J Gastroenterol 36 (7):751-8. Handa, K., M. Yamakawa, H. Takeda, S. Kimura, and...