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Checkpoint and Coordinated Cellular Responses to DNA Damage

Checkpoint and Coordinated Cellular Responses to DNA Damage

Checkpoint and Coordinated Cellular Responses to DNA Damage

... and spatially controlled, how Checkpoint and Coordinated Cellular Responses to DNA Damage 83 checkpoint signaling is regulated by different types of DNA damage, and howdifferent downstream cellular ... after DNA damage might expose these hi-stone modifications to present a damage- specific “histone code” to proteinsinvolved in DNA repair or checkpoint signaling6PerspectivesThe DNA damage and DNA ... genomes and to maintain genomic stability. Furthermore, the check- Checkpoint and Coordinated Cellular Responses to DNA Damage 77point seems to regulate different cellular processes in a coordinated...
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Tài liệu Báo cáo khoa học: P25a ⁄ TPPP expression increases plasma membrane presentation of the dopamine transporter and enhances cellular sensitivity to dopamine toxicity pptx

Tài liệu Báo cáo khoa học: P25a ⁄ TPPP expression increases plasma membrane presentation of the dopamine transporter and enhances cellular sensitivity to dopamine toxicity pptx

... resolved. To ensure that the flotation was due to binding to light vesicles, 1% Triton X-100 and 1% SDS were added to dissolve themembranes, as demonstrated for BIP, synaptophysin and biotinylated ... a-syn + empty vector, DAT ⁄ P25a and DAT ⁄ a-syn to obtain equal concentrations of vector DNA wereincubated in the absence and presence of 0.5 mM DA for 24 h and subjected to analysis of viability ... 2010 The Authors Journal compilation ª 2010 FEBS 499extracellular DA into the cytosol, and VMAT-2, whichtransports cytosolic DA into storage vesicles. The criti-cal role of these systems in...
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Báo cáo khoa học: Cotton GhMPK2 is involved in multiple signaling pathways and mediates defense responses to pathogen infection and oxidative stress doc

Báo cáo khoa học: Cotton GhMPK2 is involved in multiple signaling pathways and mediates defense responses to pathogen infection and oxidative stress doc

... MV (0, 5 and 10 lm) for 72 h, and thenimmersed in 80% acetone for 48 h to extract the chloro-phyll; the disks were then subjected to spectrophotometricmeasurement of chlorophylls a and b. The ... JA, and methyl viologen (MV). The ectopic expression ofGhMPK2 in transgenic tobacco plants led to enhancedresistance to fungi and viruses. This resistance wasmost probably attributable to elevated ... perceiveexternal signals and to manifest adaptive responses with appropriate physiological and morphologicalchanges [1]. At the molecular level, the perception ofextracellular stimuli and the subsequent...
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An investigation into some types of verbal responses to questions in English and Vietnamese conversation

An investigation into some types of verbal responses to questions in English and Vietnamese conversation

... indirect responses, refusals to answer, challenges to the presupposition of question, responses to implicit meaning of the question and some special responses: misunderstandings or evasive responses ... United States? (Q)B: That’s too easy. (C to Q)A: No it isn’t. (C to C)B: George Washington. (A to Q)In this study, we try to isolate some types of responses to questions which have the illocutionary ... movements and some decisions as to how the two parties are to deal with this complex mix of factors (Wardhaugh,1997). A question which is now posed to us is how we can precisely understand and interpret...
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food neophobia among the finns and related responses to familiar and unfamiliar foods

food neophobia among the finns and related responses to familiar and unfamiliar foods

... the willingness to try nine foods: pineapple,strawberry yogurt, bread cheese, beef tomato, pasha,turkey, snails, falafel balls, and genetically modi®edtomato (Figs. 1e,g,h,i and 2a,b,f,i,j). ... ®ndingthat was similar to US and Swedish populations (Frank& Hursti, 1999). Education is likely to enhance theaccess and exposures to various stimuli, events and issues, and thereby it can ... between FNS and willingness to try or eat food stimuli. Two-way analysisof variance was used to determine the main eects offamiliarity (the dichotomized form, see above) and FNG, and their interaction,...
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A comparative analysis of institutions, national policies, and cooperative responses to floods in Asia

A comparative analysis of institutions, national policies, and cooperative responses to floods in Asia

... corresponding to different kinds of resources and actions. At the simplest and most conventional level we need to look at actual structural and non-structural responses made in preparing for, and responding ... to reduce flood risks? In this context the overarching questions are how national and regional institutions are designed and what policies and measures are undertaken and what can be done to ... national and regional institutional regimes, policies and measures to protect (including preparedness, emergency response and rehabilitation) from destructive effects of floods and to reduce...
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A study on english and vietnamese responses to compliments

A study on english and vietnamese responses to compliments

... P-CRs are used to show different attitudes towards compliments such as Accept, Reject and Deflect/Evade. Second, English and Vietnamese speakers tend to use Disagreeing Responses to reject a ... verbal responses to compliments in their contrast in English and Vietnamese, this study aims to describe and analyze different types of compliment responses (CRs, hereafter) in English and Vietnamese ... compliments and CRs in New Zealand. She analyzed quantitatively the topics that compliments referred to and discussed the frequencies of giving and receiving compliments between men and women....
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Tài liệu Báo cáo khoa học: Pyruvate reduces DNA damage during hypoxia and after reoxygenation in hepatocellular carcinoma cells pptx

Tài liệu Báo cáo khoa học: Pyruvate reduces DNA damage during hypoxia and after reoxygenation in hepatocellular carcinoma cells pptx

... important intracellular antioxidant and redoxpotential regulator that plays a vital role in drugdetoxification and in cellular protection against damage by free radicals, peroxides, and toxins [13].Hypoxia ... metabolism, and onstudying DNA damage. The metabolism of glutathione and DNA breaks were investigated in hepatocellularcarcinoma HepG2 cells cultivated with or withoutpyruvate during and after ... intra- cellular and extracellular compartments: HepG2 cells were incubatedfor 6 h under normoxic and hypoxic conditions in the absence and presence of pyruvate (1 mM). Intracellular and extracellular...
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Tài liệu Báo cáo khoa học: Different mechanisms for cellular internalization of the HIV-1 Tat-derived cell penetrating peptide and recombinant proteins fused to Tat docx

Tài liệu Báo cáo khoa học: Different mechanisms for cellular internalization of the HIV-1 Tat-derived cell penetrating peptide and recombinant proteins fused to Tat docx

... and biological evidence indicates that the cellular uptake of theTat basic peptide does not involve binding to HS proteo-glycans and endocytosis.EXPERIMENTAL PROCEDURESPeptide synthesis and ... lM¯uorescein Tat peptide and analyzed by FACS.RESULTSUptake and cellular localization of ¯uorescentlylabeled Tat peptides Cellular uptake of the full-length Tat p rotein fused to GFP and/ or GST involves ... corresponding to the primarysequence of the Tat protein to provide a sulfhydryl groupfor further ligation to a ¯uorochrome or to a cargomolecule. The peptide was puri®ed by semipreparativeHPLC and...
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