... too high or central staining appeared very poor In search for an easy -to- use method to acquire, fix and store canine liver biopsies, we used the stability of 18S and 28S rRNA as markers for totalRNA ... objective was to optimize the use of a single liver biopsy, in order to minimize the number of necessary biopsies per patient, by evaluation of different methods http://www.comparative-hepatology.com/content/8/1/3 ... (Trizol and RNAeasy), and three different fixation protocols for histological studies (10% formalin, RNAlater, Boonfix) were compared Histological evaluation was based on hematoxylin-eosin (HE) and...