... chemokine expression by lipopolysaccharide in vitro and in vivo J Immunol 1999, 163:1537-1544 Goodman RB, Pugin J, Lee JS, Matthay MA: Cytokine-mediated inflammation in acute lung injury Cytokine ... released by macrophages or airway epithelial cells upon activation plays an important role in neutrophilic inflammation induced by LPS [4] Indeed, TNF-α triggers the release of CXC chemokines, such ... during acute lung injury or COPD [1,6] In mice, airway inflammation induced by LPS is associated with an increase of the matrix metalloproteinases (MMP), MMP-2 and MMP-9 [7,8] MMP are a family...