... mechanisms of autocatalytic zymogen activation and has been sufficiently justified [11,29–31] Previously, kinetic analyses of the reactions, whereby a zymogen is activated both intra- and intermolecularly ... for each of these mechanisms with the experimental results, these authors suggested a reaction mechanism including both intra- and intermolecular activation of the zymogen by the action of the ... route of intramolecular activation of the zymogen into the active enzyme, E, and one or more peptides represented by W [route (a), Scheme 3] [12,22,25–27] and a route of autocatalytic activation of...