60733 roles in the family idioms and conversation

Báo cáo khoa học: Respective roles of the catalytic domains and C-terminal tail peptides in the oligomerization and secretory trafficking of human acetylcholinesterase and butyrylcholinesterase potx

Báo cáo khoa học: Respective roles of the catalytic domains and C-terminal tail peptides in the oligomerization and secretory trafficking of human acetylcholinesterase and butyrylcholinesterase potx
... both the catalytic domain and the C-terminal t peptides contribute to the control of oligomerization and secretion, in a complex interplay Origin and significance of the difference between the t peptides ... C-terminal t peptides not in uence the catalytic activity of AChE and BChE We examined the possible in uence of the C-terminal peptides on the AChE and BChE activities by comparing the catalytic ... followed by small C-terminal t peptides of 40 and 41 residues, respectively In the present study, the catalytic domains are indicated by capital letters (A and B) and the C-terminal peptides by lower...
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Báo cáo khoa học: Essential roles of lipoyl domains in the activated function and control of pyruvate dehydrogenase kinases and phosphatase isoform 1 pot

Báo cáo khoa học: Essential roles of lipoyl domains in the activated function and control of pyruvate dehydrogenase kinases and phosphatase isoform 1 pot
... processing unit Fig E2 and E3BP domains and their binding interactions E2 subunit domains: L1, N-terminal lipoyl domain; L2, inner lipoyl domain; B, E1 binding domain; I, oligomer-forming, acetyl-transferase-catalyzing ... L2 In a second region at the other end of the L2 domain, mutation of glutamates 16 2, 17 9 and 18 2, and glutamine 18 1 greatly reduces binding Indeed, substitution of alanine or glutamine for Glu182 ... acetyl-transferase-catalyzing inner domain E3BP domains: L3, N-terminal lipoyl domain; B, E3 binding domain; I, inner domain which associates with the inner domain of E2 Dotted connections indicate binding interactions...
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Báo cáo khoa học: FLIP and MAPK play crucial roles in the MLN51-mediated hyperproliferation of fibroblast-like synoviocytes in the pathogenesis of rheumatoid arthritis pdf

Báo cáo khoa học: FLIP and MAPK play crucial roles in the MLN51-mediated hyperproliferation of fibroblast-like synoviocytes in the pathogenesis of rheumatoid arthritis pdf
... followed by the blocking of FLS apoptosis FLIP upregulated by MLN51 plays a crucial role in the anti-apoptosis of MH7A cells We examined whether FLIP was involved in the antiapoptosis of MH7A cells ... affect MLN51 and FLIP induction in MH7A cells (Fig 5B), indicating that ERK is unlikely to be involved in the GM-CSF-mediated induction of MLN51 and FLIP in RA FLSs These data suggest that MAPK, particularly ... 3551 FLIP and MAPK in MLN51-mediated FLS hyperproliferation J.-E Ha et al A Fig Summary diagram showing the role of MLN51 in the GM-CSF-mediated proliferation of RA FLSs via MAPK activation and induction...
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Báo cáo khoa học: Bcl-2 and Bcl-xL play important roles in the crosstalk between autophagy and apoptosis pdf

Báo cáo khoa học: Bcl-2 and Bcl-xL play important roles in the crosstalk between autophagy and apoptosis pdf
... current opinions on how Bcl-2 and Bcl-xL are involved in the molecular events The crosstalk between the autophagy and apoptosis may redefine the roles of Bcl-2 and Bcl-xL in oncogenesis and tumor ... cancer treatment by modulating the two processes Bcl-2 and Bcl-xL in the apoptosis Bcl-2 and Bcl-xL inhibit apoptosis The Bcl-2 protein family was discovered by analysis of the t(14–18) chromosomal ... originally discovered in a yeast twohybrid screen as a Bcl-2- interacting protein, and was the first human protein shown to be indispensable for autophagy [44] The interaction between Beclin and...
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The chemical components of detergents and their roles in the washing process

The chemical components of detergents and their roles in the washing process
... fabrics and on the washing machine’s heating elements - stabilise alkalinity at the correct level throughout the washing process thus giving good soil removal and enabling the other components of the ... present in the washing machine from previous washes, thus reactivating any remaining detergents and improving detergent performance No other single chemical offers all, or even most, of these different ... necessarily involves the inclusion of a number of complex, new chemicals and a complete restructuring on the detergent's formula, often with significant increase in other existing ingredients For each of...
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Báo cáo y học: "ADAMTS proteinases: a multi-domain, multi-functional family with roles in extracellular matrix turnover and arthritis" pdf

Báo cáo y học:
... Cal S, Obaya AJ, Llamazares M, Garabaya C, Quesada V, LopezOtin C: Cloning, expression analysis, and structural characterization of seven novel human ADAMTSs, a family of metalloproteinases with ... surface involves C-terminal cleavage by glycosylphosphatidyl inositolanchored membrane type 4 -matrix metalloproteinase and binding of the activated proteinase to chondroitin sulfate and heparan ... indicating that other ADAMTS proteins might also be upregulated by inflammatory cytokines The induction of ADAMTS-4 mRNA in β-amyloid-treated rat astrocytes supports an inflammatory-associated...
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Báo cáo y học: "Bench-to-bedside review: Functional relationships between coagulation and the innate immune response and their respective roles in the pathogenesis of sepsis" ppsx

Báo cáo y học:
... carboxyl terminus of peptides and proteins In the case of fibrin, removal of carboxyl-terminal lysine residues renders the fibrin less sensitive to lysis by decreasing the ability of plasminogen and ... Functional interrelationships between clotting and the innate immune response The close ancestral and functional linkage between clotting and inflammation is readily appreciated in study of human physiologic ... [7,15] Any injury to the exoskeleton of the crab immediately jeopardizes the integrity of the internal milieu of the organism Not only is there a real threat of loss of internal contents of the crab...
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CHARACTERISATION OF GLUTAMYL TRANSPEPTIDASE AND ELUCIDATING ITS ROLES IN THE PATHOGENESIS OF HELICOBACTER PYLORI

CHARACTERISATION OF    GLUTAMYL TRANSPEPTIDASE AND ELUCIDATING ITS ROLES IN THE PATHOGENESIS OF HELICOBACTER PYLORI
... recombinant proteins in E coli  Raising and characterizing specific polyclonal and monoclonal antibodies against GGT  Determining the subcellular localization of GGT in H pylori  Investigating the ... Assessing the ability of GGT in inducing IL-8 generation in various cell types  Analyzing GGT entry into host cells and its probable downstream effects  Examining the role of GGT in vacuolation induction ... ability to maintain long-term colonization in the gastric mucosa of the mice compared to the wild type strain, indicating the importance of catalase in the chronic persistence of H pylori (Harris...
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