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Nanoparticles of biodegradable polymers for controlled and targeted delivery of protein drugs and small molecule drugs

Nanoparticles of biodegradable polymers for controlled and targeted delivery of protein drugs and small molecule drugs

Nanoparticles of biodegradable polymers for controlled and targeted delivery of protein drugs and small molecule drugs

... NANOPARTICLES OF BIODEGRADABLE POLYMERS FOR CONTROLLED AND TARGETED DELIVERY OF PROTEIN DRUGS SMALL AND MOLECULE DRUGS BY LEE SIE HUEY (B.Sc (Hons.), NUS) A THESIS SUBMITTED FOR THE DEGREE OF ... backbone of PLA and PLGA to form PLA-TPGS and PLGA-TPGS block copolymers These block copolymers are an example of amphiphiles Their uses as different carriers for delivery of protein and anticancer ... Peptide /protein drug delivery 15 2.2.1 Structural aspect of protein 15 2.2.2 Challenges in peptide /protein drug delivery 17 2.2.3 Approaches for delivery of peptide /protein drugs...
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Multifunctional nanoparticles of biodegradable polymers for diagnosis and treatment of cancer

Multifunctional nanoparticles of biodegradable polymers for diagnosis and treatment of cancer

... MULTIFUNCTIONAL NANOPARTICLES OF BIODEGRADABLE POLYMERS FOR DIAGNOSIS AND TREATMENT OF CANCER PAN JIE (M ENG., TIANJIN UNIVERSITY) A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY ... nanoparticles of biodegradable polymers for QDs formulation for targeted and sustained imaging for cancer diagnosis at its early stage Two polymers of poly(lactide)-vitamin E TPGS (PLA-TPGS) and vitamin ... loading QDs for targeted and sustained imaging for cancer diagnosis at its early stage 4) to prepare biodegradable polymeric multifunctional nanoparticles for targeted chemotherapy and imaging...
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Trastuzumab decorated nanoparticles of biodegradable polymers for targeted small molecule chemotherapy

Trastuzumab decorated nanoparticles of biodegradable polymers for targeted small molecule chemotherapy

... (PLGA/MMT) nanoparticles decorated by trastuzumab for targeted chemotherapy of breast cancer Biomaterials 2008; 29(4): 475-486 Sun B, Feng SS Trastuzumab decorated nanoparticles for targeted chemotherapy ... conjugation of trastuzumab on NP surface for targeted drug delivery Experiments were carried out to investigate the feasibility of the obtained NPs for targeted delivery of small molecule drugs The trastuzumab ... objective of this research is to study the effectiveness of two systems of trastuzumabfunctionalized nanoparticles for targeted drug delivery In the first part, a novel system of trastuzumab- decorated...
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Nanoparticles of biodegradable polymers for delivery of therapeutic agents and diagnostic sensitizers to cross the blood brain barrier (BBB) for chemotherapy and MRI of the brain

Nanoparticles of biodegradable polymers for delivery of therapeutic agents and diagnostic sensitizers to cross the blood brain barrier (BBB) for chemotherapy and MRI of the brain

... Functions of the Blood Brain Barrier The main function of the blood brain barrier is to protect the brain The BBB serves as an impermeable wall to prevent the entry of agents from outside of the brain ... Anatomy of the Blood Brain Barrier 1.1.2 Functions of the Blood Brain Barrier 1.1.3 Clinical Significance of the Blood Brain Barrier 1.2 METHODS TO OVERCOME THE BLOOD BRAIN BARRIER 1.3 NANOPARTICLES ... polymers to deliver drugs across the blood brain barrier and the surface coating plays key roles in determining the extent of the particles to cross the BBB To further investigate the potential for the...
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Nanomedicine  multifunctional nanoparticles of biodegradable polymers for cancer treatment

Nanomedicine multifunctional nanoparticles of biodegradable polymers for cancer treatment

... NANOMEDICINE: MULTIFUNCTIONAL NANOPARTICLES OF BIODEGRADABLE POLYMERS FOR CANCER TREATMENT LIU YUTAO (B.Sc., Fudan University) A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY ... development of cutting-edge nanoparticles of biodegradable polymers with overall fascinating performance demonstrates the progress in the field of nanomedicine for cancer treatment viii NOMENCLATURE ... 173 LIST OF PUBLICATIONS 193 vi SUMMARY Multifunctional nanocarriers have been regarded as potent candidates for efficient cancer nanomedicine Nanoparticles of biodegradable polymers...
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Paclitaxel loaded nanoparticles of biodegradable polymers for cancer chemotherapy

Paclitaxel loaded nanoparticles of biodegradable polymers for cancer chemotherapy

... PACLITAXEL LOADED NANOPARTICLES OF BIODEGRADABLE POLYMERS FOR CANCER CHEMOTHERAPY KHIN YIN WIN (M Sc., NUS) A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY DEPARTMENT OF CHEMICAL ... potential analysis of various formulations of paclitaxel- loaded PLGA nanoparticles 81 Figure 13 XRD analyses of paclitaxel, TPGS, blank PLGA nanoparticles and paclitaxel- loaded PLGA nanoparticles ... of paclitaxel- loaded PLGA nanoparticles, fluorescent PLGA nanoparticles and standard PS nanoparticles 133 Table Surface chemistry of the formulation materials and the paclitaxel- loaded PLGA nanoparticles...
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Nanoparticles of biodegradable polymers for gene therapy of hepatitis b

Nanoparticles of biodegradable polymers for gene therapy of hepatitis b

... DNA: NANOPARTICLES < /b> OF < /b> BIODEGRADABLE < /b> POLYMERS < /b> FOR < /b> GENE < /b> THERAPY < /b> OF < /b> HEPATITIS < /b> B JUNPING WANG (B Eng., ZJU, China) A THESIS SUBMITTED FOR < /b> THE DEGREE OF < /b> MASTER OF < /b> SCIENCE GRADUATE PROGRAM IN BIOENGINEERING ... gastrointestinal (GI) barrier and blood brain barrier, thus can benefit oral gene < /b> delivery and brain gene < /b> delivery vii LIST OF < /b> FIGURES AND TABLES Fig.2.1 Basic components of < /b> cationic lipids (DC-Chol) ... most of < /b> the current polymers < /b> for < /b> gene < /b> delivery Finally, the author discussed the application of < /b> biodegradable < /b> nanoparticles < /b> for < /b> gene < /b> delivery which is viewed as the most promising field for < /b> current...
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Nanoparticles of biodegradable polymers for delivery of diagnostic therapeutic agents their potential application in brain cancer therapy

Nanoparticles of biodegradable polymers for delivery of diagnostic therapeutic agents their potential application in brain cancer therapy

... NANOPARTICLES OF BIODEGRADABLE POLYMERS FOR DELIVERY OF DIAGNOSTIC/ THERAPEUTIC AGENTS: THEIR POTENTIAL APPLICATION IN BRAIN CANCER THERAPY YU QIANRU (B.Eng, Southeast ... Limitations in Modern Chemotherapy 2.2 Brain Cancers and Blood Brain Barrier (BBB) 2.2.1 Brain cancers and cancer treatment 2.2.2 Introduction to the blood brain barrier 2.2.2.1 History of blood brain ... the delivery of therapeutic agents into the brain Paclitaxel, one of the most widely used anti -cancer drugs, has limited application in treating brain tumor because of the existence of BBB Of...
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báo cáo khoa học:

báo cáo khoa học: "Development of PEGylated PLGA nanoparticle for controlled and sustained drug delivery in cystic fibrosis" pptx

... = 100 μm intranasal drug delivery helps in improving the efficacy of drug by assisting in its lung delivery and biodistribution The PLGA- PEGPS341 provides controlled and targeted drug delivery ... drug- delivery therapeutics for CF and other airway diseases like COPD and asthma The nanodrug delivery system here provides controlled and sustained PS-341 delivery for selective inhibition of ... protein-processing machinery (proteostasis) The nano -drug delivery system used here provides a feasible alternative for controlled and sustained PS-341 delivery to lungs for selective inhibition of...
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identification, design and synthesis of oxygenated hydrocarbon-based carbon dioxide-soluble polymers for chemical and petroleum engineering applications

identification, design and synthesis of oxygenated hydrocarbon-based carbon dioxide-soluble polymers for chemical and petroleum engineering applications

... ABSTRACT IDENTIFICATION, DESIGN AND SYNTHESIS OF OXYGENATED HYDROCARBON-BASED CO2-SOLUBLE POLYMERS FOR CHEMICAL AND PETROLEUM ENGINEERING APPLICATIONS Lei Hong, Ph.D University of Pittsburgh, 2006 ... defended on March 29, 2006 and approved by Dr Eric J Beckman, Professor, Chemical and Petroleum Engineering Department Dr J Karl Johnson, Professor, Chemical and Petroleum Engineering Department ... Professor, Department of Chemistry Dissertation Director: Dr Robert M Enick, Chairman and Professor, Chemical and Petroleum Engineering Department ii Copyright © by Lei Hong 2006 iii ABSTRACT IDENTIFICATION,...
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synthesis and characterization of novel polymers for functional and stimuli responsive silicon surfaces

synthesis and characterization of novel polymers for functional and stimuli responsive silicon surfaces

... ProQuest Information and Learning Company 300 North Zeeb Road P.O Box 1346 Ann Arbor, MI 48106-1346 Synthesis and Characterization of Novel Polymers for Functional and Stimuli Responsive Silicon Surfaces ... Modification of Silicon/ SiO2 Surfaces with TTMS and Random Copolymers 241 241 241 242 Results and Discussion 7.4.1 Synthesis of TTMS 7.4.2 Synthesis of Poly(EHAM-co-AIEMA) 7.4.3 Silicon/ SiO2 ... describes the synthesis and characterization of novel amphiphilic block copolymers used as stimuli responsive coatings on surfaces The behavior of surfaces covalently modified with these copolymers...
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Oxo-biodegradable Polymers Present Status and Future Perspectives

Oxo-biodegradable Polymers Present Status and Future Perspectives

... Heskins, M and Guillet, J.E (1968) Macromolecules, 1, 97–98 Harlan, G and Kmiec, C (1995) Ethylene-carbon monoxide copolymers, in Degradable Polymers: Principles and Applications (eds G Scott and D ... initiation and control, in Biodegradable Plastics and Polymers (eds K Doi and R Fukuda), Elsevier, Amsterdam, pp 79–91 28 Jakubowicz, I (2003) Polym Degrad Stab., 80, 39–43 29 Weiland, M., Daro, A., and ... Haines, J.R and Alexander, M (1974) Appl Environ Microbiol., 28, 1084–1085 Heat, D.J., Lewis, C.A., and Rowland, S.J (1997) Org Geochem., 26, 769–785 Albertsson, A.-C., Andersson, S.O., and Karlsson,...
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synthetic polymers for biotechnology and medicine - ruth freitag

synthetic polymers for biotechnology and medicine - ruth freitag

... version) ISBN: 1-5 870 6-0 8 1-7 (soft cover version) Library of Congress Cataloging-in-Publication Data Synthetic polymers for biotechnology and medicine / [edited by] Ruth Freitag p ; cm (Biotechnology ... bacteria Over the last years a Synthetic Polymers for Biotechnology and Medicine, edited by Ruth Freitag ©2003 Eurekah.com 20 Synthetic Polymers for Biotechnology and Medicine number of transfection ... including synthetic and natural polymers, metals, ceramics and composites have become increasingly important in medicine and pharmaceutics.1 8-2 1 Of these groups, Synthetic Polymers for Biotechnology and...
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