Structural characterization of nogo proteins implications for biological functions and moleculedesign of therapeutic applications

... 54 3.1.1 Expression and structural characterization of NogoA-(567-748) and Nogo- 66 55 3.1.2 CD and NMR characterization of Nogo- 40 60 3.1.3 NMR structure determination of Nogo- 40 66 3.1.4 Discussion ... of Nogo- 60 and Design of Structured and Active Nogo- 54 76 3.2.1 Preliminary structural characterization 77 3.2.2 Structure and 15N backbone dynamics of Nogo- 60 78 3.2.3 Design of structured and ... of Nogo- B by ELM 96 Figure 3.3.4 CD and NMR characterization of the Nogo- B N-terminus 99 Figure 3.3.5 CD and NMR characterization of the Nogo- 33 101 Figure 3.3.6 CD and NMR characterization of...

Báo cáo khóa học: Structural characterization of the human Nogo-A functional domains Solution structure of Nogo-40, a Nogo-66 receptor antagonist enhancing injured spinal cord regeneration ppt

... characterization of the Nogo -A functional domains (Eur J Biochem 271) 3513 Fig Schematic representation of the domain organization of the human Nogo -A protein (A) The domain organization of human ... fragments The Nogo -A cDNA (designated KIAA 0886) was obtained from the Kazusa DNA Research Institute (KazusaKamatari, Kisarazu, Chiba, Japan) A DNA fragment encoding a 182 residue Nogo -A fragment ... (designated as Nogo -A( 567–748); Fig 1) was generated by PCR with a pair of primers: 5¢-CG CGCGCGCGGATCCACTGGTACAAAGATTGCT-3¢ (forward) and 5¢-CGCGCGCGCCTCGAGCTAAAAT AAGTCAACTGGTTC-3¢ (reverse) A DNA...

Báo cáo y học: "Most nuclear systemic autoantigens are extremely disordered proteins: implications for the etiology of systemic autoimmunity" pps

... acids, they may be masked and physically unavailable to the immune system [49] Finally, as shown by the ProPred analysis, disordered regions are only rarely apt to be T cell epitopes In summary, the ... immune system is further amplified by the results of the analysis of MHC II T cell epitopes using the ProPred server shown in Fig 5b Here we can see that the extremely disordered regions of the virus ... proteins in the Sm particle that are rarely if ever autoantigens, lack long disordered regions (data not shown) Experimental evidence that nuclear systemic autoantigens are extremely disordered...

IDENTIFICATION, KINETIC AND STRUCTURAL CHARACTERIZATION OF SMALL MOLECULE INHIBITORS OF ALDEHYDE DEHYDROGENASE 3A1 (ALDH3A1) AS AN ADJUVANT THERAPY FOR REVERSING CANCER CHEMO-RESISTANCE

... Parajuli IDENTIFICATION, KINETIC AND STRUCTURAL CHARACTERIZATION OF SMALL MOLECULE INHIBITORS OF ALDEHYDE DEHYDROGENASE 3A1 (ALDH3A1) AS AN ADJUVANT THERAPY FOR REVERSING CANCER CHEMORESISTANCE ALDH ... reactivity and metabolism Important Aldehyde Dehydrogenase family members ALDH3A1 and its importance in cancer chemoresistance 19 Cyclophosphamide and its mechanism of cytotoxicity ... acid by ALDH3A1 in the presence of NAD(P)+ and water Important aldehyde dehydrogenase family members Structural, kinetic and knockout studies of several human aldehyde dehydrogenase isozymes...

Tài liệu The Decline of Traditional Banking: Implications for Financial Stability and Regulatory Policy doc

... fast-growing area of their off-balance-sheet activities Finally, we examine the implications of the changing nature of banking for ﬁnancial fragility and regulatory policy THE DECLINE OF TRADITIONAL ... been conducted by the Bank for International Settlements (the “Promisel Report”), the Bank of England, the Group of Thirty, the Of ce of the U.S Comptroller of the Currency, the Commodity Futures ... Banking and Quarterly Banking Profile FRBNY ECONOMIC POLICY REVIEW / JULY 1995 29 terest income and therefore overstates the decline in the proﬁtability of traditional banking Another indicator of the...

Tài liệu Báo cáo khoa học: NMR structural characterization of HIV-1 virus protein U cytoplasmic domain in the presence of dodecylphosphatidylcholine micelles doc

... bear structural similarity to the tight loop formed by L73–V78 of VpUcyt in the presence of DPC micelles Although the structural motifs adopted by the cytoplasmic domain of VpU appear to be qualitatively ... structure of the cytoplasmic domain of the human immunodeﬁciency virus type encoded virus protein U (Vpu) Int J Pept Protein Res 47, 297–310 Willbold D, Hoffmann S & Rosch P (1997) Secondary ¨ structure ... Schomburg D (1993) Synthesis and characterization of the hydrophilic C-terminal domain of the human immunodeﬁciency virus type 1-encoded virus protein U (Vpu) Pept Res 6, 79–87 Wray V, Federau T,...

Tài liệu Báo cáo khoa học: Puriﬁcation and structural characterization of a D-amino acid-containing conopeptide, conomarphin, from Conus marmoreus docx

... Kumagaye KY, Nakajima K, Watanabe T, Kawai T, Kawakami Y, Niidome T, Sawada K, Nishizawa Y et al (1994) Omega-agatoxinTK containing D-serine at position 46, but not synthetic omega-[L-Ser46]agatoxin-TK, ... Inoue A, Kawakami Y, Nishizawa Y, Katayama K & Kuwada M (1995) Isolation and characterization of a peptide isomerase from funnel web spider venom J Biol Chem 270, 16719–16723 Torres AM, Tsampazi ... assigned and integrated, with concomitant cycles of structure calculations for evaluation of distance and angle constraint violations as well as assignments of additional peaks based on the preliminary...

Tài liệu Báo cáo khoa học: Structural characterization of Ca2+/CaM in complex with the phosphorylase kinase PhK5 peptide pdf

... residue in the N-terminal part of the peptide that binds in the with the C-terminal domain in CaM However in PhK5 Trp357 is found at the C-terminal end of the peptide This suggests that either PhK5 ... occurring on binding of the peptide and could indicate that the binding of PhK5 to Ca2+⁄ CaM is similar to that observed for Ca2+⁄ CaM binding to isolated peptides from other protein kinases ... structure of a Ca2+ ⁄ CaM ⁄ peptide complex The N-terminal domain is in blue and the C-terminal domain is in pink The peptide is shown as a green helix and the termini are indicated with N and...

Báo cáo khoa học: Structural characterization of a novel branching pattern in the lipopolysaccharide from nontypeable Haemophilus inﬂuenzae pot

... Schweda, E.K.H (2001) A rapid and sensitive procedure for determination of 5-N-acetyl neuraminic acid in lipopolysaccharides of Haemophilus in uenzae: a survey of 24 nontypeable H in uenzae strains ... HexNAc1ÆHex5ÆHep4ÆAnKdo-ol (Tables and 4) The Table Negative ion ESI-MS data and proposed compositions for O-deacylated lipopolysaccharide (LPS-OH) of nontypeable Haemophilus in uenzae (NTHi) strain 981 Average ... abundance was estimated from the area of molecular ion peak relative to the total area (expressed as percentage) Peaks representing less than 3% of the base peak were not included in the table Observed...

Addressing the Impact of Household Energy and Indoor Air Pollution on the Health of the Poor: Implications for Policy Action and Intervention Measures pot

... |5 Addressing the Impact of Household Energy and Indoor Air Pollution on the Health of the Poor Implications for Policy Action and Intervention Measures | Introduction Exposure to indoor air pollution ... whether the child is carried on the |9 Addressing the Impact of Household Energy and Indoor Air Pollution on the Health of the Poor Implications for Policy Action and Intervention Measures mother's ... | Addressing the Impact of Household Energy and Indoor Air Pollution on the Health of the Poor Implications for Policy Action and Intervention Measures 5.2 Intersectoral Action The fact that indoor...

Báo cáo khoa học: Functional and structural characterization of novel mutations and genotype–phenotype correlation in 51 phenylalanine hydroxylase deﬁcient families from Southern Italy docx

... analysis of the PAH gene in 51 unrelated HPA patients from Southern Italy In addition to the molecular epidemiology of PAH mutations, we characterized the functional properties of two novel mutations ... phenylalanine hydroxylase deciency in Southern Italy: a 96% detection rate with ten novel mutations Ann Hum Genet 71, 1 8519 3 10 Waters PJ (2003) How PAH gene mutations cause hyper-phenylalaninemia and ... analysis of novel mutations Among the mutations identied in our HPA population, two (i.e p.Q301P and c.707-2delA) were novel One of these mutations, p.Q301P, arises from the c.911A>C transversion in...

Báo cáo khoa học: Structural characterization of photosystem II complex from red alga Porphyridium cruentum retaining extrinsic subunits of the oxygen-evolving complex docx

... PSII essentially independent on the presence of other extrinsic proteins [44], whereas effective binding of red algal cyt c550 to the red algal PSII requires the presence of all of the other extrinsic ... occurrence of the free CP43 subunit in the fraction A of the sucrose gradient (Fig 1B, lane A) The absence of other peripheral densities in the top-view projection map of the red algal PSII core complex ... chromatography estimated the molecular mass of the Fig Schematic representation of subunit organization of the extrinsic subunits on the lumenal side of dimeric PS II in the red alga P cruentum (A,B),...

Báo cáo khoa học: Structural characterization of the lipopolysaccharide O-polysaccharide antigen produced by Flavobacterium columnare ATCC 43622 potx

... is of note that the structure of the LPS O -antigen of F columnare differs structurally from the LPS O -antigen of the ﬁsh pathogen Flavobacterium psychrophilium [21], which is a linear polymer of ... consideration of the experimental evidence thus leads to the full structure of the F columnare ATCC 43622 LPS native O-chain being an unbranched polymer of a repeating trisaccharide having the structure: ... were identical with those of authentic reference glycoses, and further conﬁrms their characterization The combined MS data and the isolation of the two aminoglycoses with the respective D-galacto...

hydrothermal synthesis and structural characterization of fe2o3sno2 nanoparticles

... the hydrothermal conditions are: x # 0:2 for Sn4þ in the a-Fe2O3 and x $ 0:7 for Fe3þ in SnO2 This paper is the ﬁrst report on the hydrothermal synthesis and structural characterization of (1 ... with coordinates of ð0; 0; zÞ occupy 2/3 of the octahedral holes in successive oxygen layers, and 1/3 of the octahedral holes with coordinates of ð0; 0; 0Þ are empty In the case of our samples, ... decomposition at 873 K, in the presence of a few percent of (SO4)22 Figs 11 and 12 show the particle morphology and stoichiometry determined by SEM and EDX examinations of the hematite-tin oxide system...

Báo cáo khoa học: Structural characterization of N-linked oligosaccharides of laminin from rat kidney: changes during diabetes and modulation by dietary ﬁber and butyric acid pdf

... Nlinked oligosaccharides of laminin during diabetes and the likelihood of dietary fiber and butyric acid in modulating these changes Results Rats experimentally induced with diabetes using streptozotocin ... Kumar et al Laminin oligosaccharide changes during diabetes Table Effect of dietary fiber and butyric acid on fasting blood sugar, urine sugar, urine volume and glomerular filtration rate (GFR) ... of dietary fiber and butyric acid on total sugar, amino sugar and sialic acid content of laminin (lgÆ100 lg)1 protein) Values are average of duplicate analyses carried out on laminin purified from...

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