implications for replicative senescence and maintenance of genome integrity

báo cáo hóa học:" Quality of data collection in a large HIV observational clinic database in sub-Saharan Africa: implications for clinical research and audit of care" docx

Ngày tải lên : 20/06/2014, 08:20

... missing and incorrect items) of 67% for OIs, 52% for ART-related toxicities, and 83% and 58% for ART discontinuation Page of and modification, respectively Nineteen of the 559 patients in the research ... 220 (49%) and 15 (3%) of 453 toxicities, and 18 (51%) and 11 (32%) of the 86 cited reasons for ART discontinuation and modification This gives a total error rate (comprising missing and incorrect ... percentage for all the individual OIs calculated using absolute number of OIs and incidence rates was similar and was within 5% of each other for most of the individual OIs, except tuberculosis and...

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Báo cáo y học: " Reduced peak oxygen uptake and implications for cardiovascular health and quality of life in patients with schizophrenia" ppsx

Ngày tải lên : 11/08/2014, 16:21

... Guidelines for the Management of Arterial Hypertension: The Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology ... Hospital, Division of Psychiatry, Department of Østmarka, Trondheim, Norway Norwegian University of Science and Technology, Faculty of Medicine, Department of Circulation and Medical Imaging, ... University of Science and Technology, Faculty of Medicine, Department of Neuroscience, Trondheim, Norway St Olavs University Hospital, Division of Psychiatry, Department of Research and Development...

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Báo cáo y học: "dentification of the prokaryotic ligand-gated ion channels and their implications for the mechanisms and origins of animal Cys-loop ion channels" ppt

Ngày tải lên : 14/08/2014, 14:21

... members of the ART-LGIC superfamily and discuss the general implications of these proteins for the mechanisms and origin of the Cys-loop receptors of the animal nervous system Results and discussion ... glutamate and cationic zinc [4-8] The receptors are also the targets of plant toxins such as nicotine and strychnine, conotoxins of snails, lophotoxins of corals, and many of the neurotoxins of elapid ... envelop the ligand, and are the principal constituents of the ligand-binding box (Figure 2) Of these, the dyad of two consecutive cysteines, which are amino-terminal to the final strand of the LBD...

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Structural characterization of nogo proteins implications for biological functions and moleculedesign of therapeutic applications

Ngày tải lên : 14/09/2015, 12:53

... of Nogo-B and Systematic Dissection of the Am-Nogo-A 92 3.3.1 Bioinformatics analysis 93 3.3.2 CD and NMR characterization of N- and C-termini of Nogo-B 97 3.3.3 CD and NMR characterization of ... and mediates chemotaxis and 3D tube formation of endothelial cells in vitro The identification of NgBR facilitate 20 understanding the function of NogoB as a regulator of vascular remolding and ... converting enzyme, formation /maintenance of the tubular network of the endoplamic reticulum (ER) and so forth Structural study of Nogo should be an indispensable requisite to understand the mechanism...

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Tài liệu The Decline of Traditional Banking: Implications for Financial Stability and Regulatory Policy doc

Ngày tải lên : 16/02/2014, 11:20

... Bank for International Settlements (the “Promisel Report”), the Bank of England, the Group of Thirty, the Of ce of the U.S Comptroller of the Currency, the Commodity Futures Trading Commission, and, ... percent of the dealers’ $6.5 trillion of notional outstandings.18 Table NOTIONAL PRINCIPAL OF INTEREST RATE AND CURRENCY SWAPS WRITTEN ANNUALLY BY UNDERLYING AND OUTSTANDING Billions of U.S Dollars ... Derivatives Safety and Soundness Act of l994 This bill directs the federal banking agencies to establish common principles and standards for capital, accounting, disclosure, and examination of ﬁnancial...

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Báo cáo khoa học: Discovery and characterization of a Coenzyme A disulﬁde reductase from Pyrococcus horikoshii Implications for the disulﬁde metabolism of anaerobic hyperthermophiles doc

Ngày tải lên : 07/03/2014, 17:20

... constant observed for the CoADR reaction Thermostability and thermoactivity of the CoADR phCoADR is stable for months at both )80 °C and )20 °C, and has half-lives of > 100 and 39 h at 85° and 95 °C, ... Addition of a second equivalent of NADPH to the EH2 form of phCoADR results in an increase in absorbance in the regions between 507 and 700 nm and 400 and 500 nm There is also an increase and FEBS ... which corresponds to the 380 and 360 nm peaks of the E and EH2 forms, respectively This result is inconsistent with reduction of the FAD and consistent with the formation of an EH2Æ NADPH complex,...

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Addressing the Impact of Household Energy and Indoor Air Pollution on the Health of the Poor: Implications for Policy Action and Intervention Measures pot

Ngày tải lên : 15/03/2014, 16:20

... of Household Energy and Indoor Air Pollution on the Health of the Poor Implications for Policy Action and Intervention Measures 6.4 Estimates of Costs The estimation of costs for scaling up and ... targeted financial support for technical development and production of appliances, and for infrastructure for marketing and transport may be justified For example in the case of the improved stoves ... indicators and systems for data collection at national level and for poor rural and urban communities where the need for information and action is greatest | 15 Addressing the Impact of Household...

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Báo cáo khoa học: Structure of a trypanosomatid mitochondrial cytochrome c with heme attached via only one thioether bond and implications for the substrate recognition requirements of heme lyase potx

Ngày tải lên : 23/03/2014, 04:21

... mitochondrial cytochromes c of euglenozoans is a longstanding puzzle It could be a means of altering the structure of these cytochromes c and ⁄ or a consequence of some biosynthetic demand A high-resolution ... model for stepwise evolution of the MIA pathway for import of cysteinerich proteins FEBS Lett 582, 2817–2825 29 Yamamoto Y & La Mar GN (1986) 1H NMR study of dynamics and thermodynamics of heme ... cysteines that form thioether bonds to the heme, and the methyl group of the alanine of the C fasciculata AXXCH heme-binding motif, which is found in place of the ﬁrst cysteine of the S cerevisiae...

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Báo cáo khoa học: Using directed evolution to improve the solubility of the C-terminal domain of Escherichia coli aminopeptidase P Implications for metal binding and protein stability pptx

Ngày tải lên : 23/03/2014, 07:20

... 50 lgÆmL)1 kanamycin and increasing concentrations of TMP for the three rounds of evolution For the first round, lgÆmL)1 TMP was used, and in the second and third rounds, 10 and 20 lgÆmL)1 TMP were ... mutants of a single-length fragment were selected for a further round of shuffling Two further rounds of shuffling were completed before a mutated fragment was selected for expression, purification, and ... genes of mutants that confer increased TMP resistance are isolated and shuffled, and the new mutant library is monitored for increasingly higher levels of TMP resistance After several rounds of evolution,...

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Báo cáo hóa học: " Expression of HIV receptors, alternate receptors and co-receptors on tonsillar epithelium: implications for HIV binding and primary oral infection" doc

Ngày tải lên : 20/06/2014, 01:20

... levels of CXCR4 and CCR5, and analysis of adjacent tissue sections indicated that many of these epithelial cells could be expressing both CXCR4 and CCR5 (Figure 4a, b) Co-expression of CXCR4 and ... HIV virions and exposed mucosal surfaces and that both the properties of the inoculum (cell free HIV virions and/ or cell associated infectivity in the form of HIV-infected cells) and the characteristics ... hours of completion of the surgery and then processed by standard methods for paraffin embedding and microtome sectioning In some instances, tissue pieces were snap frozen in liquid nitrogen for...

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Báo cáo y học: "Design and evaluation of genome-wide libraries for RNA interference screens" pps

Ngày tải lên : 09/08/2014, 20:22

... short and long dsRNAs for individual genes [12,25,26] However, the systematic and reproducible design of RNAi reagents for large sets of genes or even whole genomes using an expanded set of parameters, ... feature file) and AFF (annotation file format) formats for additional sequence analyses and straightforward reagent visualization in any genome browser Application of NEXT-RNAi for RNAi reagent ... efficiency and other features of libraries of long dsRNAs and siRNAs As examples, we performed a re-annotation Page of 12 of eight large-scale RNAi libraries designed for the Drosophila genome (Ambion,...

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Báo cáo y học: "Closure of the NCBI SRA and implications for the long-term future of genomics data storage" doc

Ngày tải lên : 09/08/2014, 22:23

... instead just store the DNA and re-sequence it as needed Certainly for bacterial genomes, that’s currently a feasible option This also avoids the problem of changing formats for digital storage DNA ... different formats or policies for data access, different reliabilities and so on GenBank, ENA and DDBJ have been hugely valuable for the community, not least because they have had strict policies for ... doi:10.1186/gb-2010-12-3-402 Cite this article as: GB Editorial Team: Closure of the NCBI SRA and implications for the long-term future of genomics data storage Genome Biology 2011, 12:402 ...

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báo cáo khoa học: " Assisted injection in outdoor venues: an observational study of risks and implications for service delivery and harm reduction programming" pps

Ngày tải lên : 11/08/2014, 18:20

... Canada: Application for an exemption under Section 56 of the Controlled Drugs and Substances Act for a scientific purpose for a pilot supervised injection site Office of Drug Strategy and Controlled ... daily cocaine injectors, and individuals involved in the sex trade, and were less likely to be Aboriginal Our findings have implications for the role of peer education and Lloyd-Smith et al Harm ... Johnston, Steve Kain, and Calvin Lai for their research and administrative assistance The study was supported by the US National Institutes of Health and the Canadian Institutes of Health Research...

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Báo cáo y học: "Modular architecture of protein structures and allosteric communications: potential implications for signaling proteins and regulatory linkages" pot

Ngày tải lên : 14/08/2014, 07:21

... each other, and, therefore, exhibiting a certain degree of homotropic cooperativity [32] Binding of one androstenedion (Andro2) induces conformational changes in the active site and increases ... intervals of modularity The bars represent the percentage of functional modules for each interval of modularity The number of functional modules for each range of modularity is indicated at the top of ... calculated separately for the set of the inter-modular residues and for the set of intra-modular residues The ordinate axis shows the percentage of long-range interactions for the inter-modular...

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Báo cáo y học: " xGDB: open-source computational infrastructure for the integrated evaluation and analysis of genome features" pptx

Ngày tải lên : 14/08/2014, 17:22

... and back-end components relevant to data providers and private installations The installation is straightforward and requires basic knowledge of common open source software For the purposes of ... scripts for loading features from flat files of various formats into a relational database management system, and supporting information necessary for feature configuration and cus- http://genomebiology.com/2006/7/11/R111 ... infrastructure for organization of genomic data, analysis of a wide range of inquiries about such data, and online publishing of both data and analysis results The extensible design of xGDB provides...

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BS 5440 2 2000 installation and maintenance of flues and ventilation for gas appliances of rated

Ngày tải lên : 28/09/2014, 23:27

... Regulations and in Scotland, Technical Standard K for compliance with the Building Standards (Scotland) Regulations Maintenance When attending an installation for maintenance, the provisions for air ... provisions of this part of this British Standard For dated references, subsequent amendments to, or revisions of, any of these publications not apply For undated references, the latest edition of the ... responsible Foreword Page Inside front cover ii Scope Normative references Definitions Design and materials for air vents and ducts Size and position of air vents Other aspects of ventilation Maintenance...

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Statistical methods for the detection and analyses of structural variants in the human genome

Ngày tải lên : 09/09/2015, 10:14

... METHODS FOR THE DETECTION AND ANALYSES OF STRUCTURAL VARIANTS IN THE HUMAN GENOME TEO SHU MEI A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY NUS GRADUATE SCHOOL FOR INTEGRATIVE SCIENCES AND ... analysis of the data could be more than the production of the data There is still a need for the development of new statistical/bioinformatics methods and software for the systematic analysis of CNV/SV ... parts of the genome They are abundant in the human genome and covers almost 50% of the human genome (Treangen et al., 2012) Table 2.2 summarises repeat type, number, percentage of genome covered and...

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a study on the main features of short jokes and implications for teaching speaking to students of grade 12 at ngoc tao upper secondary school

Ngày tải lên : 25/12/2015, 17:19

... stand for Judge Schonorrer -and if you’ll stand for him you’ll stand for anything (Stand for something that means toterate) Ambiguity on adjective Puns play on the ambiguity relying on words of ... pains and sorrows It makes us tolerance, and keeps us gay and young Humour is considered as a form of entertainment and a form of human communication with its aim to make people laugh and feel ... expressing ideas or performing before the others - help me feel relaxed and get more knowledge of foreigners‟ sense of humour No (7.5%) - the topics of short jokes not meet the demand of the oral examination...

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A cross cultural analysis of english textbook for grade 10 and suggestion of supplementary activities for students’ cross cultural awareness

Ngày tải lên : 07/09/2013, 12:58

... for a much richer understanding of culture than heretofore envisaged by the majority of language teachers 2.2 Common approaches to the teaching of culture In the history of culture teaching different ... textbook among 23 the set of English textbooks for senior high school in Vietnam and the analysis of its cultural content may set an initial step for the analysis of the whole set of high school English ... of frequency and percentage of types of references to Vietnamese and foreign cultures according to Checklist One Types of reference Reference to Vietnamese culture Reference to foreign culture...

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