Studies on the cytoprotective role of autophagy in necrosis

... mechanisms using in vitro mammalian cell models The following investigations have been conducted: (i) examining the role of autophagy in zVAD-induced necrosis by modulation of autophagy via either pharmacological ... CONCLUSIONS 163 5.1 AUTOPHAGY PLAYS A PRO-SURVIVAL ROLE IN ZVAD-INDUCED NECROSIS 5.2 ZVAD INHIBITS AUTOPHAGY VIA SUPPRESSION OF CATHEPSIN ACTIVITY 5.3 SUPPRESSION OF AUTOPHAGY BY ACTIVATION OF ... insulin Figure 3.4 Inhibition of the PI3K activity abolishes the pro-death effect of insulin on zVAD-induced necrosis in L929 cells Figure 3.5 Inhibition of mTOR activity by rapamycin abolishes the...

Tài liệu Báo cáo Y học: Studies on the nonmevalonate pathway of terpene biosynthesis The role of 2C-methyl-D -erythritol 2,4-cyclodiphosphate in plants docx

... group of Glu207 into phytoene (the main labeled component of the lipidsoluble fraction) is systematically diminished by the addition of increasing amounts of [1-3H ]2C-methyl-D -erythritol 4-phosphate ... Formation of 4-(cytidine 50 -diphospho)-2-C-methyl-D -erythritol from 2-C-methyl-D -erythritol 4-phosphate by 2-C-methyl-D -erythritol 4-phosphate cytidyltransferase, a new enzyme in the nonmevalonate ... H (2000) Studies on the nonmevalonate pathway: formation of 2-C-methyl-D -erythritol 2,4-cyclodiphosphate from 2-phospho4-(cytidine 50 -diphospho)-2-C-methyl-D -erythritol Tetrahedron Lett 41,...

báo cáo hóa học: " On the potential role of glutamate transport in mental fatigue" ppt

... fatigue is one of the symptoms of the "astheno-emotional syndrome" Although mental fatigue is not exactly the same as depression, where the patient has a feeling of not being able to anything, there ... drawing of cellularthe proinflammatory function Schematic drawing of cellular regulation of extracellular glutamate concentrations ([Glu]ec) in normal brain function (left), and in the presence of ... consequence, the information taken into the brain will be less distinct In addition, activation of astroglial networks, with induction of Ca2+ oscillations, both within and between the gap junctioncoupled...

Evaluation of the role of autophagy in fungal development and pathogenesis 2

... et al., 20 01; Suzuki and Ohsumi, 20 07) Atg19 is the cargo receptor protein involved in the Cvt pathway (Scott et al., 20 01) Atg20 and Atg24 bind PtdIns(3)P and belong to the sorting nexin family ... complementation, and RFP and GFP tagging are given in Table (specifying the backbone vector chosen and the corresponding fungal selection marker) 2. 2 .2 DNA techniques 2. 2 .2. 1 DNA extraction The DNA samples ... 13 and maintence of intracellular membrane compartments and their resident proteins in eukaryotic cells Endosomes also play a role in cellular signaling The G protein signaling occurring on the...

Evaluation of the role of autophagy in fungal development and pathogenesis 3

... 297 298 30 0 30 2 30 3 30 4 30 6 30 7 30 7 30 8 Abstract Autophagy is a bulk degradative process responsible for the turnover of membranes, organelles, and proteins in eukaryotic cells Genetic and molecular ... regulated in the atg8Δ mutant and investigate the role of autophagy and nutrient utilization during conidiation and in planta growth in Magnaporthe By genetic and biochemical studies, we show that autophagy ... strains The indicated strains were initially grown in the dark for days and then subjected to constant illumination to induce conidiation At the specified time-points post induction, the fungal...

Evaluation of the role of autophagy in fungal development and pathogenesis

... selective, depending on the specific biological circumstance and/ or the specific inducer involved Autophagy was first identified and characterized in yeast and in animal cells In recent years, autophagy ... Generation and characterization of an atg20∆ mutant in Magnaporthe 90 4.2.2 Subcellular localization of Atg20 .90 4.2.3 Investigation of non-selective autophagy and the Cvt pathway in the atg20∆ ... Yun long and Selvarai Poonguzhali, for making our lab a most pleasant and stimulating working environment The TLL community, especially the sequencing lab and the microscopy and imaging facility...

ELUCIDATING THE ROLE OF AUTOPHAGY IN ZEBRAFISH MODELS OF LIVER CANCER

... transgenic line Establishing the role of autophagy in liver cancer 4.1 Preliminary data implicating autophagy inhibition in liver cancer 4.2 Establishing double transgenic lines with liver- specific ... as a model organism in the study of human diseases including cancers, we aim to investigate the role of autophagy in liver cancer using our established zebrafish liver cancer models As little study ... ELUCIDATING THE ROLE OF AUTOPHAGY IN ZEBRAFISH MODELS OF LIVER CANCER SIM HUEY FEN, TINA (B.Sc.(Hons.)), NUS A THESIS SUBMITTED FOR THE DEGREE OF MASTER OF SCIENCE DEPARTMENT OF BIOLOGICAL...

The noneffects of class on the gendered division of labor in the home

... political mobilization of classes on the one hand and gender relations on the other One might argue that the Class and gender in the home 157 degree of housework egalitarianism in the society as a ... desire into practice The broad institutions of male domination, Engels argued, are built upon this foundation On the basis of this reasoning, Engels' argued that male domination would wither away in ... least in part an outcome of a process of contestation, con¯ict and bargaining The class location of husbands and wives bears on their respective power in the household in two ways First, as in any...

Tài liệu Báo cáo khoa học: Comparative studies on the functional roles of N- and C-terminal regions of molluskan and vertebrate troponin-I pdf

... 6A,B) In the present study, we compared the functional roles of the N- and C-terminal regions of 4482 H Tanaka et al molluskan and vertebrate TnI and revealed for the ﬁrst time that (a) the alternative ... of the troponin complex In molluskan muscles, the C-terminal region does not function and troponin regulates contraction only through the activation exerted by the N-terminal region of TnI Experimental ... amount of nonspeciﬁc precipitation of the TnI-fragment was also monitored by simultaneous centrifugation of the sample containing no actin-tropomyosin under the same conditions Reconstitution of...

Center for Audit Quality Observations on the Evolving Role of the Auditor: A Summary of Stakeholder Discussions doc

... CENTER FOR AUDIT QUALITY OBSERVATIONS ON THE EVOLVING ROLE OF THE AUDITOR A SUMMARY OF STAKEHOLDER DISCUSSIONS Introduction Over the years, the role of the public company auditor has been examined ... to the roundtable participants to assure that it fairly describes the observations made during the sessions CENTER FOR AUDIT QUALITY OBSERVATIONS ON THE EVOLVING ROLE OF THE AUDITOR A SUMMARY OF ... information or the levels of assurance that would be appropriate Also, some CENTER FOR AUDIT QUALITY OBSERVATIONS ON THE EVOLVING ROLE OF THE AUDITOR A SUMMARY OF STAKEHOLDER DISCUSSIONS participants thought...

Báo cáo khoa học: Studies on the regulatory properties of the pterin cofactor and dopamine bound at the active site of human phenylalanine hydroxylase pptx

... of phosphorylation rate seen at the concentration x of H4biopterin vo is the rate in the absence of H4biopterin and vmin is the rate at very high concentrations of H4biopterin The observed Hill ... H4biopterin, the oxidized cofactor H2biopterin and the catecholamine inhibitor dopamine From Fig 3A it is seen that on preincubation with saturating concentrations (Fig 3B) of the biopterin cofactors ... binding changes the position and orientation (relative to the catalytic iron) and the hydrogenbonding network of the bound H4biopterin Moreover, the substrate induced repositioning of the cofactor also...

Báo cáo khoa học: "The key role of semantics in the development of large-scale grammars of natural language" pdf

... captures, in German trimming necessarily results in trimming something off something else; in the case of example (9) above trimming the bush results in trimming the dry branches off the bush ... argument of the embedded stateof-affairs Finally, as far as direct arguments are concerned, in Koenig and Davis (2000) these are predicted to link off the value of the KEY attribute 3.1 The verbs ... this is what the semantic type in (16) captures 3.3 Impingement Predicates In order to capture the semantic properties of the arguments of the most representative verb of the impingement predicates...

CITY DIPLOMACY: THE EXPANDING ROLE OF CITIES IN INTERNATIONAL POLITICS potx

... Koninklijke Bibliotheek, The Hague Pluijm, Rogier van der City Diplomacy: The Expanding Role of Cities in International Politics / Rogier van der Pluijm – The Hague, Netherlands Institute of International ... subdivisions of states and have neither legal standing nor independent presence in formal international institutions The existence of two legal spheres makes the legal position of cities acting in the international ... happens: from the rise of the internet and the spread of McDonalds to the establishment of the International Criminal Court and the emergence of global terrorism Focusing on the implications of globalization...

Báo cáo khoa học: Analyzing the catalytic role of Asp97 in the methionine aminopeptidase from Escherichia coli potx

... mutants of the MetAP-I from E coli S Mitra et al affect the DG value for the binding of the rst metal ion; however, the entropic factor (TDS) for the binding of the rst metal ion decreases in the ... Co(II)-binding site, and indeed bidentate binding of Glu97 may prevent binding of the solvent ligand that appears to be present in other mono-cobalt(II) species of EcMetAP-I Combination of these ... metal-binding site, but also probably assists in binding and positioning the substrate through interactions with the N-terminal amine The 6256 data reported herein highlight the complexity of the...

The functional role of emotions in aesthetic judgment pot

... Kant, aesthetic judgments can be either sensory or reflecting Sensory aesthetic judgments are based on our feelings and reflecting aesthetic judgments are judgments of beauty and judgments of the ... is the origin of aesthetics and what is an aesthetic judgment) lies in a better understanding of the connections between the visual centers in the brain, the emotional limbic2 structures and the ... model regarding the interactive formation of aesthetic experience More specifically, by exploring the role of emotions in aesthetic experience; their evolutionary origin; and their functional significance...

Xem thêm

Từ khóa: the key role of semantics in the development explain the functional role of music in african traditional society the functional role of music in african traditional society explain the semantic role of language in communication on the epistemological value of metaphors in modern neurology closing remarks on the important role of design projects effects of imidacloprid on the neural processes of memory in honey bees the future role of wind in the electric power sector review ten empirical studies on the impact of inflation on economic growth in nigeria ten empirical studies on the impact of inflation on economic growth in nigeria aristotles ideas on the role of music in education description on the role of technology in enabling communication at the workplace aristotles ideas on the role of music in education experimental studies on the survival of pathogens in frozen foods this book provides information on the clinical relevance of blood groups and on the importance of blood group antibodies in transfusion medicine in particular Báo cáo thực tập tại nhà thuốc tại Thành phố Hồ Chí Minh năm 2018 Nghiên cứu sự biến đổi một số cytokin ở bệnh nhân xơ cứng bì hệ thống Báo cáo quy trình mua hàng CT CP Công Nghệ NPV Giáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôit Giáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôit Giáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôit Quản lý hoạt động học tập của học sinh theo hướng phát triển kỹ năng học tập hợp tác tại các trường phổ thông dân tộc bán trú huyện ba chẽ, tỉnh quảng ninh Phối hợp giữa phòng văn hóa và thông tin với phòng giáo dục và đào tạo trong việc tuyên truyền, giáo dục, vận động xây dựng nông thôn mới huyện thanh thủy, tỉnh phú thọ Phát triển mạng lưới kinh doanh nước sạch tại công ty TNHH một thành viên kinh doanh nước sạch quảng ninh Phát triển du lịch bền vững trên cơ sở bảo vệ môi trường tự nhiên vịnh hạ long Nghiên cứu về mô hình thống kê học sâu và ứng dụng trong nhận dạng chữ viết tay hạn chế Định tội danh từ thực tiễn huyện Cần Giuộc, tỉnh Long An (Luận văn thạc sĩ)Thơ nôm tứ tuyệt trào phúng hồ xuân hương Sở hữu ruộng đất và kinh tế nông nghiệp châu ôn (lạng sơn) nửa đầu thế kỷ XIX Kiểm sát việc giải quyết tố giác, tin báo về tội phạm và kiến nghị khởi tố theo pháp luật tố tụng hình sự Việt Nam từ thực tiễn tỉnh Bình Định (Luận văn thạc sĩ)Quản lý nợ xấu tại Agribank chi nhánh huyện Phù Yên, tỉnh Sơn La (Luận văn thạc sĩ)BT Tieng anh 6 UNIT 2 chuong 1 tong quan quan tri rui ro Nguyên tắc phân hóa trách nhiệm hình sự đối với người dưới 18 tuổi phạm tội trong pháp luật hình sự Việt Nam (Luận văn thạc sĩ)Giáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vật