Investigations on the cellular and neuroprotective functions of nogo AReticulon 4a

... by Nogo- A expression The same effects are also observed by Nogo- B expression On the other hand, while Nogo- C and RTN3 confer some degree of protection against serum deprivation, staurosporine and ... in the inhibition of neurite outgrowth 1.2 Molecular characterization of Nogo- A 1.2.1 Nogo: part of the Reticulon family Identification and characterization of the gene encoding IN-1 antigen, Nogo- ... Localization of Nogo- A in CNS 124 7.2 Enrichment of Nogo- A at the paranode and its interaction with Caspr 125 7.3 Interaction of Nogo- A with RTN3 127 7.4 Neuroprotection by Nogo- A and the possible...

Báo cáo khoa học: "Comparative studies on the pathogenicity and tissue distribution of three virulence variants of classical swine fever virus, two field isolates and one vaccine strain, with special regard to immunohistochemical investigations" ppt

... in the cytoplasm of the epithelial (Figure 8), mononuclear and reticular cells When using the probe on the sections of the uninfected animals or the BHV-5 specific probe on the sections of the ... species The observations are useful for the early diagnosis of classical swine fever, with special regard to the detection and identification of the very mild or inapparent clinical manifestations The ... pathology and to compare the applicability of virus detection methods These observations will contribute to a better understanding of the viral pathogenesis and to the introduction of more effective...

Báo cáo " Study on the characteristics and catalytic properties of Pt/SBA-15 in the selective oxidation of D-Glucose " potx

... was dispersed inside the pore of support material (a) 3.3 Catalytic activities of Pt/SBA-15 in the oxidation of D-glucose The results of the oxidation of D-glucose carried out on Pt/SBA-15 catalyst ... Conclusions Figure HPLC-RID image of the products of D-glucose oxidation on PS-1 catalyst On the other hand, the reaction on Pt/SBA15 catalysts with pH control not only showed a high conversion, ... catalyst, the conversion decreased significantly The pH at the end of the reaction was about 2.7 This condition facilitated the formation of gluconolactone and disaccharide and inhibited the catalyst...

Báo cáo khoa học: Context-dependent effects of proline residues on the stability and folding pathway of ubiquitin docx

... mutants of the yeast protein conﬁrms this We have explored the context-dependent effects of proline on ubiquitin stability by introducing a number of substitutions at positions P37 and P38 The equilibrium ... region (residues 21–35) N terminal to the X37 and X38 mutation sites, and the sequence of the short helix (residues 38–40) and fourth strand of b-sheet (residues 42–46) on the C-terminal side of ... WT*, and that the substitutions are not signiﬁcantly perturbing the position of the TSE along the folding pathway [51,52] We have considered the P37/P38 mutations simultaneously and constructed the...

Báo cáo khoa học: Effects of salt on the kinetics and thermodynamic stability of endonuclease I from Vibrio salmonicida and Vibrio cholerae potx

... stoichiometries of participation of water, cations and anions in speciﬁc and non-speciﬁc binding of lac repressor to DNA Possible thermodynamic origins of the ‘‘glutamate effect’’ on protein–DNA ... function optimally Effects of mutations The point mutations are not in the immediate vicinity of the active site situated at the bottom of the positively charged pocket, but are still likely ... ⁄ Km in the region of 108 s)1Æm)1) shows that the reaction is nearly diffusion controlled, suggesting that the rate-limiting step is either substrate binding or dissociation As all mutations affect...

Báo cáo khoa học: Isothermal unfolding studies on the apo and holo forms of Plasmodium falciparum acyl carrier protein Role of the 4¢-phosphopantetheine group in the stability of the holo form of Plasmodium falciparum acyl carrier protein docx

... The chaotrope-induced unfolding was almost fully reversible in both forms of the protein Removal of the perturbation makes the protein regain its native form The unfolding reactions of both forms ... as the major and the minor forms of the holoACP structure, on the basis of their percentage contributions (65% and 35%, respectively) to the overall structure of the protein The structures of the ... better stability than the other form (Fig 4C) The DG of stability is on an average 20% greater in the case of the holoprotein as compared to the apoprotein Similarly, the Cm of the holo form always...

Báo cáo khoa học: Effects of cardiomyopathic mutations on the biochemical and biophysical properties of the human a-tropomyosin docx

... rather than on the position of the mutation in the polypeptide chain, as demonstrated by the biophysical assays Our studies have provided additional contributions to the understanding of the effects ... charge of Tm The two other mutations (A63V and K70T) are located at the N-terminal region, far from the troponin binding region and occur at the g position of the repeat The K70T mutation also ... stability of the mutant Tms The mutations did not affect the structure of the protein as there was no signiﬁcant alteration in the function or in the amount of the secondary structure However, the mutations...

influence of binders on the sensing and electrical characteristics of wo3-based gas sensors

... by changing the distribution of interface states and the electron occupation on them In some cases, even the concentration of the adsorbed gas ions can be measured from the change of potential ... rather than the temperature dependence of adsorptionrdesorption kinetics of NO x gas region width, and e is the permittivity of the semiconductor From the charge neutrality condition between the ... ambient gas and the electrical resistance in NO x gas It is discussed, from these facts, that the binders affect the gas sensing characteristics of WO film through the modification of the chemical...

Báo cáo "Effects of Zn content on the magnetic and magnetocaloric properties of Ni-Zn ferrites " pdf

... direction of magnetic moment of A ions and magnetic moment of B1 and B2 ions Comparing MSt and MSe from Tab 2, we could determine the canting angle between magnetic moments of B1 and B2 ions in ... superparamagnetic properties of Ni -Zn ferrite for nano-bio fusion applications ware reported [13] In this paper we study magnetic and electric properties including canting structure of Ni -Zn ferrites ... lattice constant and volume of unit cell increase with Zn content in the samples due to larger ionic radius of Zn2 + ion (0.82 Å) substituted for Ni2+ ion (0.78 Å) The X-ray density, the real density...

Báo cáo khoa học: Effects of a tryptophanyl substitution on the structure and antimicrobial activity of C-terminally truncated gaegurin 4 doc

... a GGN4 analogue with both the C-terminal 14 residue truncation and the substitution of the aspartic acid at position 16 by tryptophan, showed antimicrobial activity comparable to that of native ... the GGN4 analogues, including the native GGN4, showed a strong negative band near 200 nm and a weak and broad band around 222 nm, indicating a predominantly random-coil conformation with a slight ... perpendicular to the helical axis in panels A and B, and is parallel to the helical axis in panels C and D rapid exchange of the Hz amino protons This observation indicates that the lysine side-chains are...

EFFECT OF STORAGE TEMPERATURES ON THE PHYSIOLOGICAL AND BIOCHEMICAL PROPERTIES OF HYLOCEREUS POLYRHIZUS

... (Bui et aI., 2004) There were studies that only compare the effect of drying methods alone (Chan et aI., 2009); and also study on the optimization of extraction conditions on herbs (Chirinos ... 20 20 21 22 23 2.6 Effect of Extraction Methods on Antioxidant Activity of Herbs 2.6.1 Effect of Extraction Solvents 2.6.2 Effect of Extraction Time 2.6.3 Effect of Extraction Temperature 24 24 ... optimization of both drying and extraction methods on herb had not being studied, the main ·objective of this study was to study the effect of extraction and drying methods on antioxidant activity on...

effects of recognition versus disclosure on the structure and financial reporting of share based payments

... moneyness of options between the pre and post periods for disclosure (recognition) As Murphy’s [1999] findings suggest, some firms grant options based on the number and others grant options based on the ... disclosure- only financial reporting regime versus a recognition regime The purpose is to understand how recognition versus disclosure in financial reporting affects both real actions the number of ESOs ... requiring disclosure (recognition) Under the assumption that compensation follows a random walk, I test H1 and H2 using changes in the number of option grants, contractual length of options, and moneyness...

báo cáo hóa học: " e differential mediating effects of pain and depression on the physical and mental dimension of quality of life in Hong Kong Chinese adults" pptx

... et al.: The differential mediating effects of pain and depression on the physical and mental dimension of quality of life in Hong Kong Chinese adults Health and Quality of Life Outcomes 2010 8:1 ... mediation is established if the association between depression and QoL is reduced to zero The Sobel test [24] determined whether pain carried the influence of depression to QoL These criteria were ... pain- depression- QoL mediation chain by testing the differential effects on the physical and mental dimension of QoL independently Regression analyses showed that pain and depression impacted differently...

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