In silico prediction of the caspase degradome
In silico prediction of the caspase degradome
... monocytes Internalization of death receptors Caspase- 9 Initiator caspase of intrinsic pathway NA Caspase- 10 Initiator caspase of extrinsic pathway NA Caspase- 11 Initiator caspase of extrinsic pathway ... through caspase- 3 cleavage of upstream initiator caspases; caspase- 8 and caspase- 9 Interestingly, while most caspases are involved in apoptosis, either as initiator or executioner caspases, emerging ... Caspase- 1, caspase- 5 and caspase- 11 are thought to be inflammatory caspases as they are primarily involved in the processing of the inflammatory cytokines Remarkably, key apoptotic caspases such as caspase- 3,...
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Báo cáo khoa học: In silico analysis of the adenylation domains of the freestanding enzymes belonging to the eucaryotic nonribosomal peptide synthetase-like family pot
... organisms is intriguing It appears worthwhile to carry out a deeper investigation on the extent of similarity between the A domains of the aminoacyl adenylate-forming enzymes of the freestanding enzymes ... containing a PQQ binding domain, is supposed to be involved in lysine degradation and to convert the a-aminoadipate semialdehyde to a-aminoadipate [12] Lys2, possessing a NADPH-binding domain, ... N-terminal domains are homologous to the A and T domains from NRPS systems and the C-terminal part contains a redox cofactor binding site for either pyrroloquinoline quinone (PQQ) or NADPH In particular,...
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Báo cáo y học: " Research In silico modeling of the specific inhibitory potential of thiophene-2,3-dihydro-1,5-benzothiazepine against BChE in the formation of β-amyloid plaques associated with Alzheimer''''s disease" doc
... al., In silico modeling of the specific inhibitory potential of thiophene-2,3-dihydro-1,5-benzothiazepine against BChE in the formation of ?-amyloid plaques associated with Alzheimer's disease Theoretical ... whereas the activity of AChE declines BChE may, therefore, play a more prominent role in ACh hydrolysis in the aging brain The presence of BChE in the amyloid plaques and neurofibrillary tangles of ... Compound A in the active sites of ChEs The docking of Compound A with both ChEs has provided valuable information about the nature of the binding interactions of benzothiazepine with these enzymes...
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Báo cáo khoa hoc:" Prediction of the response to a selection for canalisation of a continuous trait in animal breeding" pps
... d It can be shown that the conditional expectation of a performance future offspring of some animal i of the parent population is equal to and the variance given the performances of all the ,i ... ,i d Y of a animals is where us and vs are parts of equation (42), and Cs are submatrices of equation (44) Note that all the individuals in the analysis are involved in these formulae APPENDIX ... means and standard deviations over generations of canalising selection Several aspects appear: with a high heritability h!, the population mean tends in a linear manner towards the optimum in a...
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Báo cáo y học: " In silico modeling indicates the development of HIV-1 resistance to multiple shRNA gene therapy differs to standard antiretroviral therapy" docx
... the gene therapy ex vivo and returned to the patient to engraft and to continuously give rise to a supply of gene- containing CD4+ progeny T cells through the thymus [21] A proportion of all infected ... effects of HIV Methods This stochastic model of gene therapy for HIV incorporated the introduction of multiple anti-HIV shRNA into HSC cells which then differentiated into gene- containing progeny CD4+ ... harbouring a reduction in fitness will not survive in the presence of an adequate gene therapy The dynamics of virus outgrowth will be determined by i) efficacy of the gene therapeutic inhibiting...
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Báo cáo y học: "In silico evidence for the species-specific conservation of mosquito retroposons: implications as a molecular biomarker" ppt
... devastating impact of diseases such as malaria on individuals and nations within malaria endemic areas, if such nanoparticles are shown by trials to have promise for eradicating malaria, it may be ... sprayed directly into the breeding areas of mosquito larvae, namely stagnant water for the anopheles, these nanoparticles may achieve their purpose if they come quickly into contact with the larvae ... quinquefasciatus quinquefasciatus quinquefasciatus quinquefasciatus quinquefasciatus quinquefasciatus quinquefasciatus Identity strain strain strain strain strain strain strain strain strain strain strain...
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How group work is used in speaking lesson of the first year major students of english at viet nam university of commerce
... using group work in the speaking lesson at VUC 1.2 Aims of the study The purpose of this study is to explore the reality of the use of group work in the speaking lesson of 1st- year English major ... Faculty of English of the University of Commerce in implementing group work? What hinders the 1st -year major students at University of Commerce in participating in group work? 1.4 Scope of the study ... at University of Commerce in group work? What hinders teachers at Faculty of English of the University of Commerce in implementing group work? What hinders the 1st year students at University of...
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A research proposal submitted in partial fulfillment of the requirements for the degree of Master of Business Administration
... Philippines; Macro is in Thailand and Taiwan, Carrefour from France is in Taiwan; and Wellcome is in Taiwan, Hong Kong, Mainland China and Singapore Major Japanese department stores are in most Asian cities ... mushrooming all over the country’s main cities at an unprecedented growth rate And in Indonesia, the changing spending patterns within the Jakarta area are contributing to an increase in the use of department ... itself as the top quality supplier for the upper end of the market and tries to present an international image (Kawahara and Speece, 1994) Singapore is the easiest place in Asia for international...
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An analysis of modality in some speeches of the president obama = phân tích tính hình thái trong một số bài phát biểu của tổng thống obama luận văn tốt nghiệp đại học
... Vinh university Foreign languages depaterment ********** An analysis of Modality in some speeches of the president Obama (Phân tích tính tình thái số phát biểu tổng thống Obama ) graduation thesis ... and discourse, text analysis and discourse analysis And then, the author mentions to the notion "modality" with the definition, types of modality, modal meanings and expressions of modality They ... means of expressing modality to persude the hearers Therefore, we decide to research on modality in some speeches of Obama to find the similarities between modality in speeches and in the other...
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Tài liệu Báo cáo khoa học: Investigation and prediction of the severity of p53 mutants using parameters from structural calculations pptx
... (PREDict MUTants) , was developed for prediction of the severity of p53 mutants The method was trained on a set of known mutants and subsequently evaluated on another set The method is based on parameters ... À yÞ2 where x and y are values from the two parameters measured, and x and y are the mean values for the respective parameters Thermally sensitive mutants There are several p53 mutants whose ... singlenucleotide mutations affecting the central domain of p53 For each variant, the values of all parameters used in the severity prediction are given On the basis of these values, a severity score is presented,...
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Tài liệu Báo cáo khoa học: Characterization of chitinase-like proteins (Cg-Clp1 and Cg-Clp2) involved in immune defence of the mollusc Crassostrea gigas docx
... from the oyster Crassostrea gigas [5] Interestingly, this protein, named C gigas chitinase-like protein (CgClp1) was found to be involved in the control of growth and remodelling processes in a ... composed of the sole Glyco_18 domain, the C-terminal tail of C gigas CLPs may not noticeably contribute to the structure and the function of these proteins Interestingly, Cg-Clp1 and Cg-Clp2 C-terminal ... based on the conserved amino acid sequences of the catalytic domain of members of the GH18 family resulted in the amplification of an expected 147 bp sequence Cloning and sequencing of this fragment...
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Tài liệu Báo cáo khoa học: Phylogenetic relationships in class I of the superfamily of bacterial, fungal, and plant peroxidases pptx
... essential proximal histidine (Fig 4A,C,D) However, in all C-domains of catalase– peroxidases, there is a conserved arginine (Arg622 in HalomarCPc) in the corresponding position, indicating that these ... and discussion Conserved regions and typical motifs in the sequences of class I peroxidases Sixty heme peroxidases belonging to class I of the plant peroxidase superfamily were aligned with the ... examined in MyctubCPn by mutating Ser315 to a threonine [39] The mutated protein did not activate isoniazid because of the introduction of a steric hindrance in the access channel Hence, it is...
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