Claudin 1 is the direct target of RUNX3 in gastric epithelial cells
Claudin 1 is the direct target of RUNX3 in gastric epithelial cells
... Proteins in Mouse 71 Gastric Epithelial Cells 4 .1. 2 TJ Proteins and TGF-β Pathway 73 4 .1. 3 RUNX3 and claudin- 1 in TGF- β Pathway 74 4 .1. 4 claudin- 1 Expression in Mouse Gastric Epithelial Cells ... analysis of claudin- 1 expression 77 upon induction by RUNX3 in SNU16 cell line 4.5 Immunodetection of claudin- 1 in mouse gastric epithelial 78 x cells and tissue samples 4.6 hclaudin -1 promoter 81 ... in gastric carcinogenesis (16 6) Claudin- 23 on the other hand, was found to be down-regulated in the intestinal type of gastric cancer (16 7) All these reports pointed to the link of the diminished...
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Báo cáo khoa học: Slc12a2 is a direct target of two closely related homeobox proteins, Six1 and Six4 docx
... oligo cDNA probe and a sense cDNA probe (complementary to the antisense) for mouse Slc1 2a2 mRNA were designed as follows; Slc1 2a2 antisense, 5¢-ATCTTCACAAGAAAAAT CACCTGGTACCAAGGATGT; Slc1 2a2 sense, ... Regulation of Clcn5 promoter by Six1 and Six4 (C) Trans-activation of Slc1 2a2 promoter by Six1 and Six4 (D) Transactivation of myogenin promoter by Six1 and Six4 (E) Gel-retardation assays of Flag Six1 ... genes of Six1 and Six4 Table S1 A complete list of potential target genes regulated by Six1 and ⁄ or Six4 in mk4 cells Fig S1 Scatter plot analysis of microarray data Logscale scatter plots of normalized...
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Báo cáo y học: "Stanniocalcin-1 promotes tumor angiogenesis through up-regulation of VEGF in gastric cancer cells" ppt
... staining of STC-1 in tumor tissues of nude mice STC-1 was detected on the membrane of tumor cells (D) Immunohistochemical staining of PCNA in tumor tissues of nude mice PCNA was detected in the ... Signaling Technology, USA) at 1: 1000, and the anti-btubulin rat monoclonal antibody (Beyotime, China) at 1:1000 VEGF Assay VEGF content in tumor culture supernatants was quantified by an enzyme-linked ... 3D) STC-1 promotes VEGF expression primarily through PKCbIIand ERK1/2 signaling pathway To understand the regulation of VEGF expression by STC-1, we investigated the main signaling pathways related...
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The mechanistic studies of the anticancer potential of artesunate in human cancer cells
... Nanyang Technological University, Singapore (Silver Best Poster Award) vi THE MECHANISTIC STUDIES OF THE ANTICANCER POTENTIAL OF ARTESUNATE IN HUMAN CANCER CELLS Table of Contents DECLARATION ... ART induced autophagy in human cervical cancer HeLa cells evidenced by the increase of autophagic flux In the search of the mechanisms for ART-induced autophagy, we found that ART inhibits mechanistic/ mammalian ... eIF4E binding protein beclin-1-regulated autophagy AMP activated protein kinase artesunate bafilomycin A1 Bax-interacting factor big mitogen-activated protein kinase bovine serum albumin cycloheximide...
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Studies of the anticancer potential of andrographolide in human cancer cells
... the importance of PT in the mitochondrial apoptosis, because in the absence of the hallmarks of PT, including the loss of the inner membrane potential and the rupture of the outer membrane, the ... hypoxia), and they found that the type, strength and kinetics of the target gene profiles depend on the levels of p53 in the cell, the type of inducing agent, and the cell type investigated (Wang ... suggesting the anticancer potential of this compound However, the molecular mechanisms are largely unknown Therefore, in order to systematically investigate the anticancer properties of Andro, the...
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Runx3 protects gastric epithelial cells against epithelial mesenchymal transition induced cellular plasticity and tumorigenicity
... biology of gastric epithelial cells due the loss of RUNX3 and how they contribute to tumorigenicity are not fully understood To investigate this, the Runx3+ /+.p53-/- and Runx3- /-.p53-/- gastric epithelial ... lines 121 Figure 6.1 A model summarising the role of Runx3 in protecting gastric epithelial cells against EMT -induced cellular plasticity and tumorigenicity 128 xii List of tables Table 2.1 List ... the tumorigenic and stem-like subpopulation in the GIF-14 line 62 4.1 Introduction 63 4.1.1 Properties of epithelial cells and mesenchymal cells 63 4.1.2 Epithelial- Mesenchymal Transition 64 4.1.3...
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Tài liệu Báo cáo khoa học: The Arabidopsis protein kinase Pto-interacting 1-4 is a common target of the oxidative signal-inducible 1 and mitogen-activated protein kinases docx
... GCTCAGTGGTGGA-3 and 5-CTGAGGGAAGCAAG AATGGA-3, OXI1 (At3g25250): 5-GACGAGATTATC AGATTTTACGC-3 and 5-AACTGGTGAAGCGGAAG AGAC-3, PTI1-4 (At2g47060): 5-CCCCAAAGAAAATG AGTTGCT-3 and 5-GCATCATTTCCTGGAGGAAAG-3 ... Journal 278 (2 011 ) 11 26 11 36 ª 2 011 The Authors Journal compilation ª 2 011 FEBS 11 31 PTI1-4, a common target of OXI1 and MAPKs C Forzani et al AGC2-3) were also identified as PTI1-4 interactors ... variety of external stimuli and consist of three sequentially acting protein kinases: a MAPK kinase kinase, a MAPK kinase (MAPKK) and finally a MAPK [19 ] However, little is known about the function and...
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Báo cáo khoa học: Alpha 1-antichymotrypsin/SerpinA3 is a novel target of orphan nuclear receptor Nur77 potx
... pcDNA3.1-GST -Nur77 plasmid pSilencer-shNur77 was prepared by overlapping strategy with primers 5¢-gacGGATCCgcagtccagccatgctccttt caagagaaggagcatg-3¢ (with BamHI), 5¢-cggAAGCTTtATC GATccaaaaaacagtccagccatgctccttctcttg-3¢ ... 5¢-GACTCGCAGACAATGATGG TC-3¢ and 5¢-GCAAACTCATCATGGGCACC-3¢ The results were normalized with b-actin, for which the primers were 5¢-ATGGTGGGAATGGGTCAGAAG-3¢ and 5¢-CA CGCAGCTCATTGTAGAAGG-3¢ Another ... CCTCCAAAAAGCACACAGA-3¢ for St-182 and St-93/ -182, 5¢-AGAAATTATCATCTTTTCCAGTCCGAGA-3¢ for St-93 and St-93/-182, and 5¢-TGGTCTTGAACTCCT CGTGATCTGCCCA-3¢ for Lst-595 pcDNA3.1 -Nur77 expression plasmid...
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Tài liệu Research " The Dissertation Committee for Fang Yin Certifies that this is the approved version of the following dissertation: Business Value of Information Technology in the Internet Economy " doc
... Business Value of Information Technology in the Internet Economy by Fang Yin, B.A Dissertation Presented to the Faculty of the Graduate School of The University of Texas at Austin in Partial ... Yin, Ph.D The University of Texas at Austin, 2002 Supervisors: Andrew B Whinston & Anitesh Barua This dissertation consists of three essays that address the issue of the business value of Information ... dollars using the chain-type price indices for Information processing equipment 22 and software” from the Bureau of Economic Analysis (BEA) Then the average of the beginning and ending values is used...
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Tài liệu Báo cáo khoa học: Rotary F1-ATPase Is the C-terminus of subunit c fixed or mobile? docx
... model constructed previously [46] (B) Snapshots of c conformation during the forced molecular dynamics calculated with the torque of 56 pNÆnm The secondary structure of c is shown for the time of ... portion of c at the level of cK18–cK21 and cD233–cS236 residues The torque was created by external forces acting on the two groups of four carbon atoms each The first group included the Ca atoms of cK18, ... [25]) The rotary shaft is comprised of 24 residues from the N-end of c subunit (cA1–cK24) and 43 residues from its C- end (cT230– cL272) The chosen portion included a major part of the coiled-coil...
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Tài liệu Báo cáo khoa học: Cell surface heparan sulfate proteoglycans Target and partners of the basic ®broblast growth factor in rat Sertoli cells pptx
... target and partners of bFGF (Eur J Biochem 269) 507 Fig Eect of bFGF in the presence of sodium chlorate on FSHstimulated estradiol synthesis in immature rat Sertoli cells Sertoli cells were incubated ... chlorate, in inducing structural alteration of HS chains, prevents the bFGF binding Our results indicate that the presence of sodium chlorate abolishes the bFGF biological effects in developing Sertoli ... bFGF partners bFGF inhibits the FSH-stimulated estradiol synthesis in Sertoli cells Sertoli cells from 20-days-old-rats were incubated for 24 h with FSH (100 ngámL)1) and increasing concentrations...
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Báo cáo khoa học: Xenopus Rbm9 is a novel interactor of XGld2 in the cytoplasmic polyadenylation complex pptx
... motifs that are characteristic of RNA-binding proteins, and an alanine-rich carboxy-terminal sequence that could be involved in protein–protein interactions Interestingly, this alanine-rich sequence, ... Gld2 Rbm9 interaction (Fig 2B) However, the RRM-containing central domain of hRbm9 (amino acids 48–269) and amino acids 269–350 of hRbm9 are not able to mediate the binding These data suggest that ... XGld2 to specific mRNA The molecular mechanism underlying XRbm9-dependent translational activation is unclear and awaits further investigations The subcellular localization of mammalian Rbm9 is...
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To Cut or Not to Cut? That is the (Central Bank’s) Question In Search of the Neutral Interest Rate in Latin America pdf
... 2012 International Monetary Fund WP/12/243 IMF Working Paper Western Hemisphere Department To Cut or Not to Cut? That is the (Central Bank’s) Question In Search of the Neutral Interest Rate in Latin ... paper) interest rate, the neutral nominal interest rate, stands for the rate of inflation, is the inflation target of the central bank, is the output gap (measured as the percentage deviation of ... INTRODUCTION An increasing number of Latin American countries have been recently strengthening their monetary policy frameworks, using the policy interest rate as the main tool to calibrate the...
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What Is the Cognitive Neuroscience of Art… and Why Should We Care? ppt
... map of the world In this map, the contours of Europe and Asia and Northern Africa are pretty well worked out But, some coastlines and interiors lack detail Off to the west, there is some sense of ... “art theorists… define the criterion of what the [aesthetic] experience is expected to be; scientists… provide a test of whether this criterion is fulfilled.”2 Or consider the case of neuroaesthetics ... ask: is there a role for touching in the aesthetic division of labour, which is indisputably dominated by the seeing and hearing that seem to safeguard the distance between the work of art and...
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Từ khóa: what is the main source of energy in the human bodywhat process is the main source of energy in the human bodywhat is the main source of energy in human bodywhat is the cost effectiveness of imaging in patients with suspected primary brain and diseasewhat is the cost effectiveness of neuroimaging in patients with headachewhat is the diagnostic performance of ultrasound in the investigation of ankle injuries in childrenwhat is the cost effectiveness of imaging in children with occult spinal dysraphismwhat is the imaging modality of choice in symptomatic carotid stenosiswhat is the imaging modality of choice in asymptomatic carotid stenosiswhat is the cost effectiveness of imaging in patients with suspected hepatocellular carcinomaaids what is the major source of aids in children todaythe role of glycans in apical sorting of proteins in polarized epithelial cellsthe emerging role of micrornas in adult stem cells1 75 the cross section of the post shown in figure p1 73 is an equilateral triangle with each side of dimension a if the averag1 the direct impact of genetically modifiedBáo cáo thực tập tại nhà thuốc tại Thành phố Hồ Chí Minh năm 2018Báo cáo quy trình mua hàng CT CP Công Nghệ NPVNghiên cứu sự hình thành lớp bảo vệ và khả năng chống ăn mòn của thép bền thời tiết trong điều kiện khí hậu nhiệt đới việt namNghiên cứu tổ chức pha chế, đánh giá chất lượng thuốc tiêm truyền trong điều kiện dã ngoạiNghiên cứu vật liệu biến hóa (metamaterials) hấp thụ sóng điện tử ở vùng tần số THzđề thi thử THPTQG 2019 toán THPT chuyên thái bình lần 2 có lời giảiĐỒ ÁN NGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWANNGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWAN SLIDEQuản lý hoạt động học tập của học sinh theo hướng phát triển kỹ năng học tập hợp tác tại các trường phổ thông dân tộc bán trú huyện ba chẽ, tỉnh quảng ninhPhát triển mạng lưới kinh doanh nước sạch tại công ty TNHH một thành viên kinh doanh nước sạch quảng ninhPhát triển du lịch bền vững trên cơ sở bảo vệ môi trường tự nhiên vịnh hạ longNghiên cứu về mô hình thống kê học sâu và ứng dụng trong nhận dạng chữ viết tay hạn chếNghiên cứu khả năng đo năng lượng điện bằng hệ thu thập dữ liệu 16 kênh DEWE 5000Thiết kế và chế tạo mô hình biến tần (inverter) cho máy điều hòa không khíSở hữu ruộng đất và kinh tế nông nghiệp châu ôn (lạng sơn) nửa đầu thế kỷ XIXChuong 2 nhận dạng rui roBT Tieng anh 6 UNIT 2chuong 1 tong quan quan tri rui roGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtQUẢN LÝ VÀ TÁI CHẾ NHỰA Ở HOA KỲ