Development and application of a high throughput assay for discovery of starch hydrolase inhibitors
Development and application of a high throughput assay for discovery of starch hydrolase inhibitors
... αglucosidase and α-amylase can significantly reduce the post-prandial increase in blood glucose after a meal, with starch as the major calorie intake The apparent advantage of the starch hydrolase inhibitors ... linear range of gelatinized starch Table Accuracy and precision of the high- throughput method Table IC50 and acarbose equivalence of inhibitors obtained by starch hydrolases Table Estimation of ... of starch involves saliva α-amylase, pancreatic αamylase, and the small intestinal brush border α-glucosidase, that is, maltaseamyloglucosidase and sucrase-isomaltase [19, 67] Determination of...
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Báo cáo hóa học: " Development and application of a biomarker assay for determining the pharmacodynamic activity of an antagonist candidate biotherapeutic antibody to IL21R in whole blood" pptx
... biomarkers, and they participated in the data analyses AAH developed the customized Spotfire tool used for data analyses and reviewed statistical analyses YG participated in the assessment and ... assay for determining the pharmacodynamic activity of an antagonist candidate biotherapeutic antibody to IL21R in whole blood Journal of Translational Medicine 2010, 8:51 Page 13 of 13 ... this basic approach (ex vivo stimulation of whole blood) to develop pharmacodynamic biomarker assays for a candidate therapeutic antibody, Ab-01 Ab-01, a human antibody generated by phage display,...
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Development and application of advanced proteomic techniques for high throughput identification of proteins
... DEVELOPMENT AND APPLICATION OF ADVANCED PROTEOMIC TECHNIQUES FOR HIGHTHROUGHPUT IDENTIFICATION OF PROTEINS HU YI (B.Sc.) A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY DEPARTMENT OF ... analysis of proteins, i.e proteomics (Pandey and Mann, 2000; Tyers and Mann, 2003) Therefore, the advancement of proteomics relies largely on the development of state -of- the-art proteomics techniques ... study, we sought to develop and apply advanced proteomic techniques from three different aspects for high- throughput identification of enzymes and their associated proteins in yeast proteome (catalomics)...
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Báo cáo y học: "Development and application of versatile high density microarrays for genome-wide analysis of Streptomyces coelicolor: characterization of the HspR regulon" ppsx
... (and Lys) tend to be over- High density IJISS DNA arrays have been developed for global analysis of Streptomyces gene expression and transcription factor binding The HspR regulatory system of S ... against the test arrays and the probe performance was scored using the following equations Firstly the Cy3 and Cy5 background-subtracted signals, designated 'g' and 'r', respectively, obtained by feature ... chaperone and protease production It is envisaged that these arrays will find widespread use in systems level analysis of Streptomyces coelicolor biology Materials and methods Streptomyces strains and...
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Development and application of a web based kanban system
... for a manufacturing company that aims to improve and enhance their manufacturing system and operations The major advantages of a Web- based Kanban system is the availability of visible and real-time ... withdrawal Kanban signal and place it in ‘on-hold’ status on Web- based Kanban screen [2] The withdrawal Kanban signal from Kanban screen will be translated to a production Kanban signal on Kanban ... common kanban Huang and Kusiak (1996) have further grouped the different types of kanban together into primary kanban, supply kanban, procurement kanban, subcontract kanban and auxiliary kanban Table...
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the development and application of an antibody based biosensor
... spectrum of BT5AA 56 Synthesis and mass spectrum of 2TAA 58 Synthesis and mass spectrum of 3TAA 59 Synthesis and mass spectrum of 5M2TAA 60 Synthesis and mass spectrum of ... from the ancient remains of marine plant and animal life under extreme heat and pressure in an anaerobic environment Depending on the composition of the organic material, varying proportions of ... Schematic of a generalized biosensor The bioreceptor and the transducer are linked such that the transducer quantifies the biorecognition event occurring between the sample and the bioreceptor The...
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DEVELOPMENT AND APPLICATION OF NEW APPROACHES FOR STUDIES OF INFLUENZA INDUCED INFLAMMATION AND DNA DAMAGE
... of influenza A (H1N1) virus infection to explore the impact of influenza infection and inflammation on DNA damage and DNA damage responses By studying chromatin phosphorylation as a measure of DNA ... of DNA damage, we show that the level of DNA damage increases following influenza infection, and we provide data that supports a role for replication fork breakdown as a driver of DNA strand breaks ... Together, these studies raise the possibility that DNA damage and DNA repair modulate the severity of influenza -induced cytotoxicity, thereby affecting tissue damage and regeneration, and ultimately...
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Development and application of computational methods and tools for adverse drug reaction and toxicity prediction
... develop and apply computational methods and tools for ADR and toxicity prediction The methods developed in this work are potentially useful for development and application of QSAR models as well ... complex, time consuming and resource intensive Toxicity is one of the primary reasons for the failure of drug candidates in later stages of drug development Moreover, adverse drug reaction (ADR) during ... drug development and safety assessment 1.2 QSAR studies for ADR and toxicity prediction To deliver promising drug candidates to reach the late stage of drug development with a higher chance of...
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Part 1 development and application of hantzsch ester and hypervalent iodine reagent
... irradiated at 14 0 oC for 40 Figure 2 -1 Library of 2 -1- 16, 2 -1- 17, 2 -1- 18, 2 -1- 19, 2 -1- 20 32 2.2.2.3 Solid-Phase Synthesis of 2 -1- 16, 2 -1- 18, 2 -1- 19 and 2 -1- 20 To illustrate the versatility of this ... process 10 Figure 1- 8 Safety-catch Linkers 12 Figure 2 -1 Library of 2 -1- 16, 2 -1- 17, 2 -1- 18, 2 -1- 19, 2 -1- 20 31 Figure 3 -1 Polymer-supported Hantzsch ester 56 Figure 3-2 Reduction of Ketimines and ... Part 1: COMBINATORIAL SYNTHESIS OF NITROGENCONTAINING HETEROCYCLES Part 2A: DEVELOPMENT AND APPLICATION OF HANTZSCH ESTER Part 2B: DEVELOPMENT AND APPLICATION OF A HYPERVALENT IODINE REAGENT...
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Development and application of bioinformatics tools for discovery disease markers and disease targeting antibodies
... differentiation, and to the design of disease- targeting molecules like small-molecule agents or antibodies for disease treatment The key disease markers determine the characteristics of disease, therefore ... effectiveness of our system on deriving stable disease markers and discovering therapeutic target One major application of marker discovery is the finding of disease targeting molecules for disease ... the beginning of Chapter two since this method is used in both disease marker discovery and disease targeting molecule design The strategies for disease marker discovery and disease targeting molecule...
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Development and application of hollow fiber protected liquid phase microextraction for trace organic analysis
... Three -phase hollow fiber- protected liquid- phase microextraction techniques combined with HPLC analysis 42 2.1 Orthogonal array designs for the optimization of static three -phase hollow fiber- protected ... the hollow fiber This thesis reports on the development and application of hollow fiber- protected LPME techniques to trace organic analysis Chapter provides an introduction to extraction, and ... pores of hollow fiber, and the aqueous acceptor solution in the lumen of the hollow fiber was repeatedly moved in and out of the hollow fiber and the syringe Compared to the dynamic three-phase...
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Development and application of hybrid finite methods for solution of time dependent maxwells equations
... domain finite methods for the numerical solution of time dependent Maxwell’s equations The two finite methods focused are FDTD and FETD methods The applications of the developed hybrid methods are ... analysis of passive microwave circuits and studies in dosimetry and tissue interaction CHAPTER TIME DOMAIN FINITE METHODS FOR SOLUTION OF MAXWELL’S EQUATIONS 2.1 Maxwell’s Equations The physics of time ... equivalence of FDTD and a particular case of FETD method a stable hybrid 3-D FETD-FDTD method was proposed The focus of this thesis is in the development and subsequent applications of efficient hybrid time...
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Development and application of novel capillary electrophoresis techniques for analysis of DNA fragments and organic pollutants
... focused on the analysis of DNA fragments; and the second part (chapter and chapter 5) focused on the analysis of organic pollutants Several novel capillary electrophoresis (CE) techniques had ... various applications, the CE applications in DNA analysis and monitoring of pollutants are of significant importance 1.3.1 CE Application in DNA Analysis DNA separation by CE has been the subject of ... for on-site analysis of various pollutants at trace level CE is found to be a versatile analytical tool for the analysis of DNA as well as pollutants Combination of DNA analysis and environmental...
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Knowledge discovery in biomedical research and drug design the development and application of biological databases
... application of data mining in the knowledge discovery in various areas of biomedical research The introduction of data mining in biomedical research in turn enables the development and application of the ... of databases is broad, both in the academia and industries This thesis reports our research on the development of biological databases and their applications in drug discovery and knowledge discovery ... type of ADRs is rare The adverse effects induced by drugs are dangerous They hinder the cure of patient, and they are also the causes of many instances of morbidity Therefore, the understanding of...
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Từ khóa: development and application of genomic models for large crop plant genomesdevelopment and application of new systemsdevelopment of a high throughput enantiomeric excess ee screening assaydevelopment and use of a risk reference framework4 aberrations of normal development and involution andi a concept of benign breast disorders based on pathogenesisimmunological assays to support the development and evaluation of a vaccine against badger tuberculosisdevelopment and maintenance of a restricted distribution of na k atpase on the plasma membraneafter closed reduction and application of a short arm cast whenextended release oral dosage forms development evaluation and application of in vitro in vivo correlations guidance 1997design annotation and application of a kinase targeted libraryreaction mechanism for esterification of palmitic acid and glucose in a high pressure acetone co2 systempericytes in development and pathology of skeletal muscletheory and application of spread spectrum systemsinterpretation and application of international financial reporting standards free downloadwiley interpretation and application of international financial reporting standards 2011 free downloadNghiên cứu sự biến đổi một số cytokin ở bệnh nhân xơ cứng bì hệ thốngNghiên cứu tổ chức pha chế, đánh giá chất lượng thuốc tiêm truyền trong điều kiện dã ngoạiNghiên cứu tổ hợp chất chỉ điểm sinh học vWF, VCAM 1, MCP 1, d dimer trong chẩn đoán và tiên lượng nhồi máu não cấpGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitPhát triển mạng lưới kinh doanh nước sạch tại công ty TNHH một thành viên kinh doanh nước sạch quảng ninhNghiên cứu về mô hình thống kê học sâu và ứng dụng trong nhận dạng chữ viết tay hạn chếNghiên cứu tổng hợp các oxit hỗn hợp kích thƣớc nanomet ce 0 75 zr0 25o2 , ce 0 5 zr0 5o2 và khảo sát hoạt tính quang xúc tác của chúngNghiên cứu khả năng đo năng lượng điện bằng hệ thu thập dữ liệu 16 kênh DEWE 5000Thơ nôm tứ tuyệt trào phúng hồ xuân hươngSở hữu ruộng đất và kinh tế nông nghiệp châu ôn (lạng sơn) nửa đầu thế kỷ XIXQuản lý nợ xấu tại Agribank chi nhánh huyện Phù Yên, tỉnh Sơn La (Luận văn thạc sĩ)Tăng trưởng tín dụng hộ sản xuất nông nghiệp tại Ngân hàng Nông nghiệp và Phát triển nông thôn Việt Nam chi nhánh tỉnh Bắc Giang (Luận văn thạc sĩ)Tranh tụng tại phiên tòa hình sự sơ thẩm theo pháp luật tố tụng hình sự Việt Nam từ thực tiễn xét xử của các Tòa án quân sự Quân khu (Luận văn thạc sĩ)chuong 1 tong quan quan tri rui roGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtTrách nhiệm của người sử dụng lao động đối với lao động nữ theo pháp luật lao động Việt Nam từ thực tiễn các khu công nghiệp tại thành phố Hồ Chí Minh (Luận văn thạc sĩ)Chiến lược marketing tại ngân hàng Agribank chi nhánh Sài Gòn từ 2013-2015Đổi mới quản lý tài chính trong hoạt động khoa học xã hội trường hợp viện hàn lâm khoa học xã hội việt nam