development and application of new systems
DEVELOPMENT AND APPLICATION OF NEW APPROACHES FOR STUDIES OF INFLUENZA INDUCED INFLAMMATION AND DNA DAMAGE
... and inset) at and dpi Scale bar 20 lm phosphorylated cH2AX by western blot (Fig 4a) Relative intensities of HA and cH2AX bands were quantified and normalized to b-actin, and the levels of HA and ... proteins involved in NHEJ and HR a Western analysis of the NHEJ proteins, Ku86 and Ku70 b, c Quantification of the levels of Ku86 (b) and Ku70 (c) Levels of Ku86 trend upward and are statistically ... division and DSB formation, 15 random images were acquired for lung sections co-stained with Ki-67 and cH2AX The number of nuclear Ki-67-positive cells in each 0.1 mm2 lung area, and the proportion of...
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DEVELOPMENT AND APPLICATION OF NEW APPROACHES FOR STUDIES OF INFLUENZA INDUCED INFLAMMATION AND DNA DAMAGE
... committee members Professor Fred Wong and Professor Marie Clement for their invaluable comments and suggestions for my thesis, and to my collaborators, Dr Damien Thévenin and Professor Donald Engelman ... pathogenicity and infectivity in hosts Many subtypes of Influenza A viruses exist, and they are classified based on their expression of different HA and NA antigens Up to early 2015, a total of 18 HA and ... host cells, (2) uncoating and vRNPs translocation into the nucleus, (3) transcription and replication of viral RNA, (4) synthesis of new vRNPs and finally, (5) assembly and budding (Figure 1.2)...
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the development and application of an antibody based biosensor
... 58 Synthesis and mass spectrum of 3TAA 59 Synthesis and mass spectrum of 5M2TAA 60 Synthesis and mass spectrum of 2MF9AA 61 Synthesis and mass spectrum of 3MF9AA ... Structures of all haptens used throughout this investigation 32 Synthesis and mass spectrum of DBTAA 53 Synthesis and mass spectrum of BT5AA 56 Synthesis and mass spectrum of 2TAA ... depth, and pollution status of the water (NRC 2003) As a result, loss/degradation of a PAH will vary both in time and space Figure Structures and names of selected PAHs Toxicity from the WAF of petroleum...
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Báo cáo hóa học: " Development and application of a biomarker assay for determining the pharmacodynamic activity of an antagonist candidate biotherapeutic antibody to IL21R in whole blood" pptx
... of IL21R and has shown efficacy in a mouse model of lupus [8] The goal of the biomarker strategy was to provide the means of avoiding toxicity due to unnecessarily high drug levels and lack of ... found that the cost of RNA assay systems compares favorably with that of ELISA systems, especially with considerations of standardization methodology Concordance between humans and cynomolgus monkeys ... et al., Development and application of a biomarker assay for determining the pharmacodynamic activity of an antagonist candidate biotherapeutic antibody to IL21R in whole blood Journal of Translational...
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Báo cáo khoa học nông nghiệp " The development and implementation of new appropriate technologies for improving goat production and increasing small-holder income in the central region of Vietnam - MS2 " potx
... production systems and in the application of new and appropriate technologies (improved housing, disease control, improved feed supply and quality, introduction of Bachthao bucks of proven genetic ... productivity and profitability on selected farms in Ninh Thuan, Binh Thuan and Lam Dong provinces; and to train local Department of Agriculture and Rural Development (DARD) staff, participating and other ... productivity and profitability on selected farms in Ninh Thuan, Binh Thuan and Lam Dong provinces; and to train local Department of Agriculture and Rural Development (DARD) staff in goat production systems...
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Project Progress Report: The development and implementation of new appropriate technologies for improving goat production and increasing small-holder income in the central region of Vietnam - MS3 " doc
... production systems and in the application of new and appropriate technologies (improved housing, disease control, improved feed supply and quality, introduction of Bachthao bucks of proven genetic ... productivity and profitability on selected farms in Ninh Thuan, Binh Thuan and Lam Dong provinces; and to train local Department of Agriculture and Rural Development (DARD) staff , participating and other ... Identification and characterisation of target farms Training and Information Dissemination Provision of improved housing and health care for goats Improve the availability and quality of feeds and forages...
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The development and implementation of new appropriate technologies for improving goat production and increasing small-holder income in the central region of Vietnam - Milestone 9" pot
... production systems and in the application of new and appropriate technologies (improved housing, disease control, improved feed supply and quality, introduction of Bachthao bucks of proven genetic ... interpretation of farming system surveys carried out in 2006 and 2008, and of the biology and productivity of goats following the introduction of new technologies to farmers in Ninh Thuan, Binh Thuan and ... productivity and profitability on selected farms in Ninh Thuan, Binh Thuan and Lam Dong provinces; and to train local Department of Agriculture and Rural Development (DARD) staff , participating and other...
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Báo cáo y học: "Development and application of versatile high density microarrays for genome-wide analysis of Streptomyces coelicolor: characterization of the HspR regulon" ppsx
... Figure Gel-shift5assays of putative new HspR targets: SCO5639 and SCO4410 Gel-shift assays of putative new HspR targets: SCO5639 and SCO4410 HspR-binding at the SCO5639 and SCO4410 promoter regions ... selected and printed to target all coding and non-coding sequences with minimal distance between the probes and maximal coverage of the genome Following experimental validation of probe signal and ... ChIP-on-chip analysis and global gene expression profiling The HspR heat-shock regulatory system of S coelicolor [6] was exploited to test and validate the sensitivity and specificity of the IJISS arrays...
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Development and application of a high throughput assay for discovery of starch hydrolase inhibitors
... in units of two or three, and the combined action of salivary and pancreatic amylase leads to the production of large amounts of maltose and maltotriose, and relatively small amounts of limit ... concentration of 18 mg/mL and sucrase concentration of 0.15 U/mL; porcine pancreas α-amylase (B) at starch concentration of 10 mg/mL, and amylase concentration is U/mL Figure 16 Eadie-Hofstee plot of acarbose ... Determination of total phenolic content of grape seeds extracts - 120 7.3.2 Determination of the proanthocyanidin profiles of grape seeds extracts - 120 7.3.3 Determination of IC50 values of...
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Development and application of computational methods and tools for adverse drug reaction and toxicity prediction
... discovery and development The purpose of drug discovery and development is to provide therapeutic compounds that are safe and efficacious in improving the quality of life and reducing pain of patients ... quality and ease of use 1.4 Objectives and significance The ultimate objective of this thesis is to improve the development and application of QSAR models by creating or improving methods and tools ... profile of SVM models on testing and validation set for AM data from CV and RS experiment 100 Table 7.2 Correlation coefficients of performance profiles of different models on testing and...
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Part 1 development and application of hantzsch ester and hypervalent iodine reagent
... Synthesis of N-Containing Heterocycles (Part 1) Development and Application of Hantzsch Ester (Part 2a); Development and Application of Hypervalent Iodine Compounds (Part 2b); Part of this thesis ... Part 1: COMBINATORIAL SYNTHESIS OF NITROGENCONTAINING HETEROCYCLES Part 2A: DEVELOPMENT AND APPLICATION OF HANTZSCH ESTER Part 2B: DEVELOPMENT AND APPLICATION OF A HYPERVALENT IODINE REAGENT ... their support i Table of Contents Acknowledgements i Table of Contents ii Summary vii List of Tables ix List of Figures xi List of Schemes xii List of Abbreviations xiii List of Publications xvi...
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Development and application of bioinformatics tools for discovery disease markers and disease targeting antibodies
... challenge of microarray data analysis The challenge comes from the presence of thousands of genes and only a few dozens of samples in currently available data From the mathematical view, thousands of ... organs, and cell lines An extensive and easily searchable database of gene expression information about the mouse Microarray database containing tens of millions of expression profiles Information and ... The motivation of this work and outline of the structure of this document are presented in Section 1.4 1.1 Overview of disease markers and therapeutic molecules Knowing the origin of a disease...
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Development and application of hollow fiber protected liquid phase microextraction for trace organic analysis
... Theories of droplet-based LPME 1.1.2.1.2 Developments and applications of droplet-based LPME 1.1.2.2 Membrane-based LPME 1.1.2.2.1 Theories of membrane-based LPME 13 13 1.1.2.2.2 Developments and applications ... effective combination of Lin and Dasgupa’s [37] and Jeannot and Cantwell’s [34] earlier works Enrichment factors of between 260- to 1600-fold were achieved within 10 of extraction of trace nitroaromatic ... 3.2.3 Results and Discussion 3.2.3.1 Derivatization and GC-MS analysis 3.2.3.1.1 GC-MS of butylated derivatives 119 119 119 3.2.3.1.2 Selection of injection temperature and purge-off time 122...
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Development and characterization of new magnesium based nanocomposites
... Symposium II: Microwave Processing of Materials, Singapore Development and Characterization of New Magnesium Based Nanocomposites xix Development and Characterization of New Magnesium Based Nanocomposites ... properties of Mg, Mg/(Y2O3+Cu) and Mg/(Y2O3+Ni) nanocomposites were evaluated and characterization studies were conducted The compressive responses of Mg and Development and Characterization of New ... Trojanova, M Cabbibo and E Evangelista, Mater Sci Eng A, 462 (2007) 225-229 Development and Characterization of New Magnesium Based Nanocomposites 10 Development and Characterization of New Magnesium...
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Development and application of hybrid finite methods for solution of time dependent maxwells equations
... characterization of complex electromagnetic systems Efficient numerical tools give engineers and designers an upper hand of assessing the performance of their design ahead of physical prototyping and measurement ... equivalence of FDTD and a particular case of FETD method a stable hybrid 3-D FETD-FDTD method was proposed The focus of this thesis is in the development and subsequent applications of efficient ... Lee, and L.-W Li Application of hybrid FETDFDTD method in the modeling and analysis of antennas.IEEE Transactions on Antennas and Propagation, Submitted N V Venkatarayalu, R Lee, Y B Gan, and...
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Development and application of novel capillary electrophoresis techniques for analysis of DNA fragments and organic pollutants
... Instrumentation and Modes Since the introduction of commercial CE instrumentation from late 1988, the speed of development and application of this technique was enhanced Requirement of only simple ... tool for some routine analytical applications, which may rival HPLC in its efficiency and breadth of application Applications of CE range from simple inorganic and organic ions [107-110], to complex ... various applications, the CE applications in DNA analysis and monitoring of pollutants are of significant importance 1.3.1 CE Application in DNA Analysis DNA separation by CE has been the subject of...
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Development and application of advanced proteomic techniques for high throughput identification of proteins
... Tandem Affinity Purification TOF Time of Flight TOF/TOF Time -of- Flight/Time -of- Flight UV Ultraviolet Y2H Yeast Two-Hybrid xvi Chapter Introduction The complete sequence of the human genome (Lander ... DEVELOPMENT AND APPLICATION OF ADVANCED PROTEOMIC TECHNIQUES FOR HIGHTHROUGHPUT IDENTIFICATION OF PROTEINS HU YI (B.Sc.) A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY DEPARTMENT OF ... large-scale analysis of proteins, i.e proteomics (Pandey and Mann, 2000; Tyers and Mann, 2003) Therefore, the advancement of proteomics relies largely on the development of state -of- the-art proteomics...
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Development and applications of new sliding mode control approaches
... 1905 DEVELOPMENT AND APPLICATIONS OF NEW SLIDING MODE CONTROL APPROACHES BY PAN YA-JUN (M.Eng Zhejiang Univ.) A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY DEPARTMENT OF ELECTRICAL AND ... order filters for a class of nonlinear systems For the tracking control tasks of a class of nonlinear uncertain systems with two cascaded subsystems, the sliding mode control and nonlinear H ∞ control ... absolute value of a number Euclidean norm of vecotr or its induced matrix norm I an identity matrix AT the transpose of A Rn the space of n-tuples of real numbers Rn×m the space of n × m real...
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Knowledge discovery in biomedical research and drug design the development and application of biological databases
... way, which offers a platform for further analysis and knowledge discovery from these data Development and application of biological databases have pushed and accelerated the development of Bioinformatics ... on the development of biological databases and their applications in drug discovery and knowledge discovery in specific areas of biomedical science The relevant technologies of database development ... ADRs targets of 11 marketed anti-HIV drugs 88 TABLE OF CONTENTS 3.3.4 Prediction results of anti-HIV drugs and analysis iv 92 CHAPTER DEVELOPMENT OF KINETIC DATABASE KDBI AND ITS APPLICATION IN...
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