... part by grants from the Ministry of Education, Culture, Sports, Science and Technology of Japan (to YN, KU-T, KS, and YT), the Ministry of Health, Labour and Welfare of Japan (to YT), and the ... Next, siRNAs were evaluated for their antiviral efficacy against three evolutionary-distant groups of HIV-1: subtypes B and B' (Thailand variant of subtype B [16]); subtype C; and CRF01_AE Each siRNA ... CRF01_AE 93JP-NH1 (AB052995) siRNA vs target sequence perfect matches imperfect matches Figure Validation of 41 siRNAs Validation of 41 siRNAs The antiviral efficacy of each siRNA was tested against...