... proteins. The likelihood of at least one round ofrefolding is thereby increased. This model of the triage decision allows sufficient time for refolding attemptsby the chaperones, keeping the amount ... presenceof 2 mm ATPcS (Adenosine-5¢-(c-thio)-triphosphate).Fig. 8. Model for the role of CHIP in the triage decision. The chaperone systemsencounter various substrates, especiallyunder heat shock ... J, Wu Y, Thompson LJ,Hohfeld J & Patterson C (2001) The co-chaperoneCHIP regulates protein triage decisions mediated byheat-shock proteins. Nat Cell Biol 3, 93–96.14 Meacham GC, Patterson...