... Multidentate pyridinones inhibit the metabolism of nontransferrin-bound iron by hepatocytes and hepatoma cells Anita C. G. Chua1, Helen A. Ingram1, Kenneth N. Raymond2 and Erica ... growth and proliferation, is uncertain. Hence, itis of interest to investigate the uptake and metabolism of NTBI in normal and cancer cells, and the effect of Fechelators on these processes.In the ... at 37 °C. The cells were then treated with pronase as described inMaterials and methods. Results are the mean and standard deviation of iron internalized by normal and iron- loaded hepatocytes...