... to be the common denominator underlying glycocalyx loss during atherogenic, inflammatory, and hyperglycemic conditions [1014] With respect to the source of free radicals involved in glycocalyx ... oxygen radical stress on the glycocalyx [11], while drugs that can increase glycocalyx production or prevent proteolytic activity may prevent or restore induced glycocalyx loss [9,12] Finally, ... Finally, infusion of glycocalyx components to reconstitute lost glycocalyx might be useful during clinical interventions Infusion of hyaluronic acid glycosaminoglycans before or shortly after the initiation...