Human exposure assessment diet dec 13 compatibility mode

... contains rice Is this use safe for acute exposures ? Chronic exposures ? LongLong-Term versus Short-Term ShortExposure Estimates LongLong-Term versus Short-Term ShortExposure Estimates For this example ... in a chronic exposure assessment, the use of median residue levels is not appropriate and results at the high end of the residue distribution should be used in an acute exposure assessment Days ... this example we will consider five days to be a chronic exposure - In estimating the residue level in a food commodity in an acute exposure assessment, there must be consideration of the variability...

Case studies dietary risk assessment dec 13 compatibility mode

... applied in calculating the chronic Population Adjusted Dose (cPAD) Acute Dietary Risk Assessment A revised acute dietary risk analysis was conducted with the DEEM The exposure at a maximum was ... mg/kg/day cPAD = aRfD 10 = 0.0003 mg/kg/day = 0.00003 mg/kg/day 10 Chronic Dietary Risk Assessment A chronic dietary risk analysis was conducted using the DRES analysis Using DRES, the Theoretical ... Acute food exposure, therefore the use is considered safe Dietary Risk from Drinking Water • The EPA determines the dietary risk based on modeling or from monitoring data from both surface and ground...

Case study cancer risk assessment dec 12 compatibility mode

... determined from the study 12/ 8/2010 Reference Dose for Alachlor The NOEL in the chronic rat study of 0.5 mg/kg/day was considered to be the appropriate endpoint for establishing the non -cancer RfD for ... (MOE) approach for the purpose of risk assessment of alachlor Since there were rare tumors seen with alachlor exposure in animal studies, for the purposes of risk assessment, the MOE for the nasal ... study conducted in dogs, alachlor was administered in doses of 0, 1.0, 3.0, or 10 mg/kg/day Systemic toxicity was noted in high dose animals as decreased body weights and body weight gains, decreased...

Uptake of organic chemicals in plants Human exposure assessment ppt

... separate exposure assessments for children, since children are not miniature versions of adults Uptake of organic chemicals in plants Paper II aims at determining the potential for accumulation of organic ... unnecessary sampling and laboratory work Human exposure assessment of organic compounds is the topic of the presented work The context is uptake of neutral organic compounds in plants determined by both ... area The uptake of xenobiotic compounds in plants is described In spite of the large differences between plants and the vast amount of organic chemicals in use, general uptake pathways to plants...

guideline derivation std setting II dec 15 compatibility mode

... by-products WHO Guidelines for Drinking-Water Quality: Drinkingderivation of GVs: non-threshold substances non- WHO Guidelines for Drinking-Water Quality: Drinkingprovisional guideline values ... • a guideline is not necessarily a standard • international guidelines are available for various media, chemicals, and commodities to assist countries in the process of standard setting setting ... 30.0 40.0 40.0 34.3 22.9 15. 0 30.0 34.2 O3 hrs 10.0 10.0 22.8 6.0 11.4 15. 0 6.0 10.3 hr 0.24 0.12 0.12 0.24 0.10 0.20 hrs 0.12 0.10 - TSP PM10 24 hrs annual 24 hrs Annual 0 .15 0.05 0.33 0.10 0.12...

risk perception dec 15 compatibility mode

... affected? Individual risk Voluntary or accepted risk? Benefits from accepting risk FACTORS CAUSING OUTRAGE FACTORS AFFECTING RISK PERCEPTION FACTOR Potentially uncontrollable risks Ability to cause ... IMPLICATIONS FOR RISK ASSESSMENT AND MANAGEMENT Stakeholder involvement in all stages of risk assessment Addressing public concerns adequately Consider risk perception issues in risk management /risk reduction ... Uncontrollable FACTORS AFFECTING RISK PERCEPTION (2) (2 FACTOR Familiar Controllable FACTORS AFFECTING RISK PERCEPTION (3) (3 CONDITIONS CONDITIONS FOR FOR INCREASED DECREASED PUBLIC PUBLIC CONCERN...

Risk characterization dec 12 compatibility mode

... for some endpoints (carcinogens, allergens?) Risk Characterization of Carcinogens Class of carcinogen Potency consideration (possibly risk figure) Mode/ mechanism of action Descriptive statement ... concerning safety and potential risks Definition of risk management /risk reduction needs Exposure Considerations Exposures from all sources and through various media Risk comparison of exposure via ... (KINETIC/DYNAMIC MODELS) MIXTURE EFFECTS DRIVE DESIGN OF TESTING METHODOLOGIES DIFFERENTIATE ETIOLOGY OF ENVIRONMENTAL DISEASES QUESTIONS ASKED BY RISK MANAGERS (1) (1 BOTTOM LINE OF RISK ASSESSMENT?...

chương 13 Rui ro va loi nhuan [Compatibility Mode]

... m c r i ro nh t nh, r i ro h th ng Figure 13. 1 R i ro phi h th ng RR có th gi m nh thêm tài s n vào danh m c Còn c g i tên: r i ro có th a d ng (diversified risk), r i ro c thù, r i ro cá bi ... r i ro kém) Su t sinh l i kỳ v ng c a m t tài s n r i ro ch ph thu c vào r i ro h th ng c a tài s n ó r i ro phi h th ng có th c gi m thi u thông qua a d ng hóa o r i ro h th ng Làm o r i ro h ... phi r i ro 2 .13% ph n thư ng rui ro th trư ng (MRP) 8.6% su t sinh l i kỳ v ng cho m i CP bao nhiêu? C phi u Beta Su t sinh l i kỳ v ng DCLK 2.685 2 .13 + 2.685(8.6) = 25.22% KO 0.195 2 .13 + 0.195(8.6)...

Indoor Air Pollution Associated with Household Fuel Use in India: An exposure assessment and modeling exercise in rural districts of Andhra Pradesh, India doc

... Indoor Air Pollution Associated with Household Fuel Use in India An exposure assessment and modeling exercise in rural districts of Andhra Pradesh, India Kalpana Balakrishnan Sumi Mehta ... important determinants The use of traditional fuels and poverty thus remain closely interlinked 2 Indoor Air Pollution Associated with Household Fuel Use in India situations In many rural areas, households ... understanding the issue of indoor air pollution exposure in homes of rural India, and has improved the evidence base for implementing and integrating environmental management initiatives in the household, ...

EXPOSURE ASSESSMENT – monitoring and modelling

... Activity EXPOSURE AND SOURCES EXPOSURE – EFFECT CHAIN SOURCES DISTRIBUTION RECEPTOR EFFECT INTEGRATED EXPOSURE EXPOSURE ASSESSMENT Environmental monitoring  Personal monitoring  Modelling ... introduction  Environmental monitoring  Personal exposure assessment  Models for exposure assessment EXPOSURE ASSESSMENT IS CONCERNED WITH THE LIKELY ACTUAL LEVELS AND DURATION OF EXPOSURE TO THE RISK ... TO ESTIMATE EXPOSURE EASE – Dermal and inhalation exposure EUSES – Environmental exposures GIS based models 36 GIS-BASED MODELS Air pollution Pesticide usage Water pollution Radon exposure 37...

Chuong1.modau.H [Compatibility Mode]

...

RADIOGRAPHIC TESTING NDT – CHUP ANH PHONG XA [compatibility mode]

... phim hay b ng n t Outline – KHÁI NI M • B c x n t • Các nguyên lý chung v phóng x • Các ngu n phóng x - Phóng x tia Gamma (γ) - Phóng x tia X • Các phương th – – – – Ch Ch Ch Ch c ch p nh p film ... l i b i nguyên nhân sau: – Nó có th thu hình nh toàn ph n v i m t l n chi u – Vi c quan sát c u trúc bên chi ti t t góc đ khác có th cung c p thêm d li u đ phân tích – Th i gian ki m tra thông ... Radiography – TIA X Không gi ng tia gamma, tia X (tia Roentgen) đư c t o b ng m t h thông máy phát H th ng thư ng bao g m m t đ u ng tia X, m t máy cao áp c u u n X-ray Radiography – TIA X (ti...

Tài liệu Personal Exposure to Air Pollution for Various Modes of Transport in Auckland, New Zealand doc

... uptake for each of the modes and each of the routes a) Route b) Route c) Route The darker boxes indicate the active transport modes Personal Exposure to Air Pollution for Various Modes of Transport ... Personal Exposure to Air Pollution for Various Modes of Transport The Open Atmospheric Science Journal, 2012, Volume Exercise Factors and Dose For those travelling by car, bus or train, a resting minute ... concentrations for each of the modes and each of the routes a) Route b) Route 2, c) Route Note that ppm values have been set to 0.1 ppm to allow plotting as a log Personal Exposure to Air Pollution for Various...

Báo cáo khoa học: Binding of berberine to human telomeric quadruplex – spectroscopic, calorimetric and molecular modeling studies pot

... S1 Temperature dependence of DG (h), DH (D) and TDS (s) for binding of berberine to the human telomeric quadruplex Fig S2 The natural logarithm of the ratio of the binding constant at a given ... thermodynamic and structural details of the quadruplex berberine interaction Results Equilibrium binding studies by UV-visible spectroscopy To gain insight into the interaction between berberine and the ... temperature, and Kb is the binding afﬁnity for the quadruplex berberine interaction DH and DS correspond to the enthalpy and entropy change for the binding, respectively, and DG corresponds to the...

Báo cáo khoa học: Human haptoglobin structure and function – a molecular modelling study pptx

... of haptoglobin receptors in human hepatoma cells Biochim Biophys Acta 1136, 14 3–1 49 20 Oshiro S, Yajima Y, Kawamura K, Kubota M, Yokofujita J, Nishibe Y, Takahama M & Nakajima H (1992) Catabolism ... structural re-arrangement of both the Hb-binding region and of the adjacent hydrophobic surface area available for binding misfolded proteins In addition, pKa calculations indicate that Asp193, as a result ... and C1R (A) , and between HPT2 and C1R (B) Conserved residues are shaded in grey; Cys residues are highlighted in yellow Above the sequence alignment, red, green and magenta bars indicate a- and...

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