LOSS OF SIMPL INCREASES TNFα SENSITIVITY DURING HEMATOPOIESIS
báo cáo khoa học: " Upregulation of microRNA-451 increases cisplatin sensitivity of non-small cell lung cancer cell line (A549)" pot
... affect the sensitivity of non-small cell lung cancer (NSCLC) cells to cisplatin (DDP) remains unclear. The aim of this study is to evaluate the roles of miR-451 in the sensitivity of NSCLC cells ... apoptosis of A549 cells were investigated.Finally, the effects of miR-451 upregulation on in vitro and in vivo sensitivity of A549 cells of DDP were alsodetermined.Results: The level of miR-451 ... induced the reverse of Bcl-2/Bax ratio.Furthermore, upregulation of miR-451 could signifi-cantly increase the in vitro and in vivo sensitivity of A549 cells to DDP. To the best of our knowledge,...
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Báo cáo y học: "Loss of genes implicated in gastric function during platypus evolution" docx
... expand our knowledge of the evolution of mam-malian genomes.Results and discussion Loss of pepsin genes in the platypus genome During the initial annotation and characterization of the plat-ypus ... S, Peer YVan de: The gain and loss of genes during 600 million years of vertebrate evolution. Genome Biol 2006, 7:R43.9. Wang X, Grus WE, Zhang J: Gene losses during human origins.PLoS Biol ... have been inactivated because of the acquisition of loss- of- function mutations. All of these genes are highly conserved in vertebrates, reflecting a unique pattern of evolution in theplatypus...
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Báo cáo y học: "The gain and loss of genes during 600 million years of vertebrate evolution" pps
... that were created during 1R/2R can still be lost after they have survived for hundreds of millions of years of evolution. Some of those genes are lostonly after the divergence of human and rodents, ... evolution<p>Phylogenetic analysis of gene gain and loss during vertebrate evolution provides evidence for the importance of early gene or genome duplication events in evolution of complex vertebrates.</p>AbstractBackground: ... ram-pant during early vertebrate evolution. A high number of duplications is also detected in TP12 (branch of the FSGD).Nevertheless, the number of detected duplications in thecommon ancestor of...
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Báo cáo y học: "Gain of a 500-fold sensitivity on an intravital MR Contrast Agent based on an endohedral Gadolinium-Cluster-Fullerene-Conjugate: A new chance in cancer diagnostics"
... T, Suzuki S, Kikuchi K, et al. Esr Study of the Electronic-Structures of Metallofullerenes - A Comparison Between La-At-C-82 and Sc-At-C-82. Journal of Physical Chemistry. 1993; 97: 13425-8. ... elec-tron-spin-resonance and mass-spectrometry studies of metallofullerenes were documented by the Dunsch group and seemed to suggest a certain potential of metallofullerenes as appropriate candidates as ... paramllofullerenes dinal relaxatioening effect, cRI CAs. pectroscopic esponsible forhe focus of thult from proptem of sp2-hyase, π-electrontron shift alonward-facing omonstration of msec],...
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Trend of domestic and international market during period 2003-2006
... about list of SMEs from taxation office or Ministry of Planning Investment (MPI). The data of provinces, their geography and firms’ density comes from the General Statistics Office (GSO) of Vietnam ... 11197Count 498 The shape of distribution is measured by Coefficient of skewness (C of S). Applying the formular: C of S= 3* (mean-median)/ standard deviation=> C of S= (22.48-21)/6=0.698 ... 498.00 • COS:The shape of distribution is measured by Coefficient of skewness (C of S). Applying the formular: C of S= 3* (mean-median)/ standard deviation => C of S= (48 699.8-40 000)/...
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Tài liệu The perception of time, risk and return during periods of speculation pptx
... for examples of thehidden-optionality models of internet stocks.283QUANTITATIVEFINANCEThe perception of time, risk and return during periods of speculationdenote the value of the market-neutral ... description of the behaviour of stock prices during market bubbles.2. A simple invariance principle and itsconsequences2.1. A stock’s risk and returnSuppose the market consists of (i) a single ... variant of thelaw of one price or the principle of no riskless arbitrage, whichdictates, more narrowly, that only two portfolios with exactlythe same future payoffs in all states of the world...
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Tài liệu Investigation of Organic Chemicals Potentially Responsible for Mortality and Intersex in Fish of the North Fork of the Shenandoah River, Virginia, during Spring of 2007 ppt
... the spring of 2007 to address the potential impact of agricultural and municipal inputs into the basin during the time of year when fish kills have been most prevalent. A suite of AOCs was ... analysis.Investigation of Organic Chemicals Potentially Responsible for Mortality and Intersex in Fish of the North Fork of the Shenandoah River, Virginia, during Spring of 2007By David A. ... Laboratory4Friends of the North Fork of the Shenandoah RiverPrepared in cooperation with the Friends of the North Fork of the Shenandoah RiverOpen-File Report 2008–1093U.S. Department of the InteriorU.S....
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Tài liệu Báo cáo khoa học: TEC family kinases in health and disease – loss-of-function of BTK and ITK and the gain-of-function fusions ITK–SYK and BTK–SYK pptx
... family of cytoplasmicenzymes that are important for several aspects of leu-kocyte biology. Both loss- and gain -of- function muta-tions in humans have been instrumental in ourunderstanding of their ... second largest family of cyto-plasmic tyrosine kinases. In 1993, loss- of- function mutations in the BTKgene were reported as the cause of X-linked agammaglobulinemia. Of allthe existing 90 ... compilation ª 2011 FEBSMINIREVIEWTEC family kinases in health and disease – loss- of- function of BTK and ITK and the gain -of- function fusions ITK–SYKand BTK–SYKAlamdar Hussain1,2,*, Liang Yu1,3,*,...
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Tài liệu Báo cáo khoa học: Nucleolin/C23 mediates the antiapoptotic effect of heat shock protein 70 during oxidative stress pptx
... and fragmentation of theirnuclei. The percentage of apoptotic cells was calculated asthe number of apoptotic cells divided by the total number of cells counted. A minimum of 500 cells were ... growthcontrol of cardiomyocytes, and its regulation may beclosely associated with the susceptibility of the cell tothe induction of apoptosis.Caspases are important molecular mediators of apoptosis ... protection of Hsp70 is lost.Taken together, our results demonstrate an impor-tant relationship among the regulation of nucleo-lin ⁄ C23, the activation of caspase-3 and the induction of apoptosis...
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Tài liệu Báo cáo khoa học: Differential expression of duplicated LDH-A genes during temperature acclimation of weatherfish Misgurnus fossilis Functional consequences for the enzyme ppt
... orexcess of kinetic energy (as a measure of temperature)and its effect on enzyme activity.Alternatively, we know of a number of examples of qualitative strategies, for example, when expression of distinctly ... activity) by means of translational control of a ⁄ b-mRNAldh–a, in accordance with the requirements of a metabolic flux at a new temperature conditions.Table 3. Content of a ⁄ b-isoforms o mRNAldh–ain ... confirmed the existence of twoLDH-A mRNAs of different lengths: short (a-isoform;mRNAaldhÀa¼ 1332 bp) and long (b-isoform; mRNAbldhÀa¼ 1550 bp). Sequence analysis of these mRNAs hasshown...
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