... irradiation, the cell lines displayed cell cycleresponses typical for either intact or defective p53 function (the presence or absence, respectively, of radiation-induced expression of the cell cycle inhibitor ... period. Cell cycle responses to TSASince cell cycle responses associated with intact or defec-tive p53 function were typically displayed by the HCT116and SW620 cell lines, respectively, effects of ... and thereby remodeling of chromatin structure,may override cell cycle checkpoint responses to DNA damage and amplify radiation-induced tumor cell death.Methods: Human colorectal carcinoma cell...