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Báo cáo y học: "Novel insights into the relationships between dendritic cell subsets in human and mouse revealed by genome-wide expression profiling" ppt

Báo cáo y học:

Báo cáo y học: "Novel insights into the relationships between dendritic cell subsets in human and mouse revealed by genome-wide expression profiling" ppt

... Biology 2008, 9:R17Open Access2008Robbinset al.Volume 9, Issue 1, Article R17ResearchNovel insights into the relationships between dendritic cell subsets in human and mouse revealed by genome-wide ... homologous human and mouse lymphoid cell types also failed to cluster together in this analysis and were closer to the other cell populationsfrom the same species within the same leukocyte family. Thisis ... describing cell types bearing mixed phenotypic and functional characteristics of NK cells and pDCs in the mouse [15,16]. Collectively, these findings raise the question of howclosely related human and...
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Báo cáo y học:

Báo cáo y học: "Structural insights into the function of the core-circadian factor TIMING OF CAB2 EXPRESSION 1 (TOC1)" ppt

... generated and these wereTOC1 and PRR phylogenyFigure 1TOC1 and PRR phylogeny. UPGMA phylogenetic tree of TOC1/PRR proteins. The groupings are strongly supported, as indicated by high bootstrap ... SJD group by the Max Planck Society and the German-Israeli Project Cooperation (DIP project H3.1) and in the HS group by the Max Planck Society.References1. Dodd AN, Love J, Webb AA: The plant ... in metal binding and also associationsto DNA-binding proteins (see below). One interesting fea-ture of the four carboxy-terminal modules is that in struc-tural searches against the three-dimensional...
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Báo cáo y học:

Báo cáo y học: "New insights into the pathogenesis of glucocorticoid-induced avascular necrosis: microarray analysis of gene expression in a rat model" potx

... implantedbeneath the skin on the lateral side of the neck by surgi-cally making an incision and developing a pocket about 2cm beyond the incision site. The pellet was placed in the pocket and the incision ... be the cause acareful history is suggested to identify other risk factors.GCs are the mainstay of therapy in most inflammatorydisorders and they are also included in most chemother-apy protocols. ... dys-function can occur where the femoral head endothelialcells react differently to the ANFH risk factors (GCs) thanother endothelial cells in the body. In keeping with the theory of endothelial...
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Báo cáo y học: "Refined study of the interaction between HIV-1 p6 late domain and ALIX" ppsx

... results in an increased affinity of the mutant late domain for ALIX probably by alleviating the bend between N and C terminus of p6. As suggested by in vivo analysis, a tightly interaction between ... budding, the complexityof which is far from being fully understood as shown by the recent finding of nucleocapsid binding to ALIX [31].Finally, by using a random strategy, we have refined the p6ΔSQKQ ... explored by using the yeast two-hybrid approach. We refined the ALIX bindingsite of p6 as being the leucine triplet repeat sequence (Lxx)4 (LYPLTSLRSLFG). Intriguingly, the deletion of the C-terminal...
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Báo cáo y học: "Platelet-Activating Factor Antagonists Decrease Follicular Dendritic-Cell Stimulation of Human B Lymphocytes" pptx

... cells in culture and stainednegatively for CD20 and CD3 and positively forCD14 and VLA-4 by flow cytometry (data notshown). In addition, viability testing indicatedthat by day 6, all B cells ... 217025,26clearly had an effect,decreasing cell proliferation (as measured by [3H]-thymidine incorporation) by 35% and the produc-tion of IgM and IgG by the isolated tonsillar cells by 45 to 75%. ... associated B lymphocytes.FDCs were plated in six well plates in completemedium; after 3 days, the nonadherent B cellswere removed, and the remaining FDCs were kept in culture. They were fed by the addition...
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Tài liệu Báo cáo khoa học: Structural insights into the substrate specificity and activity of ervatamins, the papain-like cysteine proteases from a tropical plant, Ervatamia coronaria ppt

Tài liệu Báo cáo khoa học: Structural insights into the substrate specificity and activity of ervatamins, the papain-like cysteine proteases from a tropical plant, Ervatamia coronaria ppt

... site Cys. The S3–P3 interactions aremainly governed by side chain interactions, and accordingly the amino-4-guanidinobutane (P3) moietyof E-64 orients differently in ervatamin-A and ervata-min-C. ... in stability, activity and specificity in spite of their high homology in pri-mary and tertiary structures [1,3,27]. Multiple lyso-somal cysteine proteases of this family (cathepsins)from humans ... at the interface of the domains, with a catalytic dyad com-prising residues Cys and His situated at the opening of the cleft, one from each domain. The activity of the proteases is governed by...
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Tài liệu Báo cáo khóa học: Further insights into the assembly of the yeast cytochrome bc1 complex based on analysis of single and double deletion mutants lacking supernumerary subunits and cytochrome b pdf

Tài liệu Báo cáo khóa học: Further insights into the assembly of the yeast cytochrome bc1 complex based on analysis of single and double deletion mutants lacking supernumerary subunits and cytochrome b pdf

... nucleus, synthesized by cytosolicpolysomes, and then imported into mitochondria, therebyreaching their final location in the inner membrane [17]. The similarities of the yeast bc1complex to the ... b protein was detectable in the CKL57 strain. We do not know whether the lack ofimmunoreactivity in the latter strain was due to the inabilityof the truncated protein to insert into and be ... mitochondria. Usingmitochondria there is still the possibility to detect proteins in transit and not yet inserted into the inner mitochondrialmembrane. The fact that both core proteins decreased by the...
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Báo cáo khoa học: New insights into the functions and N-glycan structures of factor X activator from Russell’s viper venom pot

Báo cáo khoa học: New insights into the functions and N-glycan structures of factor X activator from Russell’s viper venom pot

... 9–11). The remaining activity of 5 ng of RVV-X was determined by measuring the clotting time on a coagulation analyser.Biotinylation of RVV-X and far-western blotting The BiotinTagÔ Micro-Biotinylation ... subfamilyof venom C-lectin-like proteins and has one N-glycosyl-ation site and an extra Cys135 residue linking to the RVV-X heavy chain. Moreover, N-glycan profiling revealed the presence of Le and ... uptake and clearance by the liver [32,33]. Thus, it appears that sugars playimportant roles in venom toxicology, not only by increasing the solubility and stability of venom glyco-proteins, but...
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Báo cáo khoa học: New insights into the P-glycoprotein-mediated effluxes of rhodamines doc

Báo cáo khoa học: New insights into the P-glycoprotein-mediated effluxes of rhodamines doc

... simplemeasurement of the increase of the fluorescence signal(Fcyto) of the cells when they are incubated with the dye.Actually, the dye can interact with various componentsinside the cells yielding modifications ... continu-ously enters into the cells. According to Eqn (6), during dt, the increase in the intracellular rhodamin concentration is(1 + b)ÆdCi and the increase of the number of moles per cell and per ... hydrolysis is rather slow. In the case of RhI, RhII and Rh6G that penetrate rapidly inside the cells, the steady stateis reached within a few minutes and the amount ofhydrolysed compound is very low....
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báo cáo hóa học:

báo cáo hóa học:" More insights into the immunosuppressive potential of tumor exosomes" pptx

... exosomes, and CEA and HER2 in exosomes produced by carcinoma cells [9-11], supported the role of these organelles as cell- free source of tumorantigens for T cell priming and paved the way to clinicaltrials ... pres-entation with the work of Graça Raposo and Hans Geuzeof Utrecht University in the Netherlands, who reportedthat exosomes secreted by B cells could promote T cell cross-priming through the expression ... potentially involved in the induction and maintenance of tumor immunity [9].Indeed, the expression of a large panel of tumor proteinswith antigenic properties, like MelanA/Mart-1 and gp100 in melanoma-derived...
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