Báo cáo y học: "The global role of ppGpp synthesis in morphological differentiation and antibiotic production in Streptomyces coelicolor A3(2)" pdf
Báo cáo y học: "The global role of ppGpp synthesis in morphological differentiation and antibiotic production in Streptomyces coelicolor A3(2)" pdf
... significantly altered following ppGpp synthesis, and has provided new insights and greatly advanced our under-standing of the global regulatory influence of ppGpp in S. coelicolor. Materials and methodsBacterial ... in S. coelicolor independently of amino acid starvation, and dem-onstrated a link between induction of ppGpp synthesis and increased transcription of the activator gene controlling Actbiosynthesis, ... A global proteome/transcrip-tome analysis of the response of Bacillus subtilis to ppGpp synthesis induced in exponentially growing cells by addition of the leucyl- and isoleucyl-tRNA aminoacylation...
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Báo cáo y học: "The critical role of arginine residues in the binding of human monoclonal antibodies to cardiolipin" ppsx
... arginine residues in IS4VHAs reported previously, the presence of the heavy chain of IS4 plays a dominant role in binding to CL [29]. IS4VHbinds CL in combination with six of the 10 light chainstested ... sequence of IS4VH was dominant in con-ferring the ability to bind cardiolipin (CL) while the identity of the VL paired with this heavy chain was important in determining the strength of CL binding ... study reported in this paper was todefine the contribution of different CDRs, and of individualarginine residues within those CDRs, in binding to CL. Pat-terns of CDR arginine residues in the...
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Báo cáo y học: " The potential role of appetite in predicting weight changes during treatment with olanzapine" ppt
... gain during antipsycho tic drugtherapy [15].An understanding of the role of appetite changes in weight gain during antipsychotic treatment would behelpful to clinicians and patients, some of ... Study 2); Eating Inventory (EI, Study 3) [20];Food Craving Inventory (FCI, Study 3) [21]; and Ea tingAttitude Scale (EAS, a Lilly-developed scale, assessingappetite and eating behavior during ... Landry J, Reed VA, de Haan L, Maguire GA,Hoffmann VP, Milev R: A randomized controlled trial of the effect of sublingual orally disintegrating olanzapine versus oral olanzapine onbody mass index:...
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Báo cáo y học: " The crucial role of particle surface reactivity in respirable quartz-induced reactive oxygen/nitrogen species " doc
... Quarz-dust-induced production of reactive oxygen metabolites by human granulocytes. Lung1989, 167:23-32.17. Nyberg P: Polyvinylpyridine-N-oxide and carboxymethyl cel-lulose inhibit mineral dust-induced ... inflammatory response by quartz. Pul-monary ROS and RNS release is considered as a crucial and unifying factor in the quartz-induced adverse healtheffects, including fibrogenicity and carcinogenicity.Despite ... evidence showing that mod-ification of the particle surface by either grinding or coat-ing with PVNO or aluminium salts modifies quartz-induced cytotoxicity, genotoxicity, inflammogenicity and fibrogenicity...
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Báo cáo y học: " The predictive role of serum and bronchoalveolar lavage cytokines and adhesion molecules for acute respiratory distress syndrome development and outcome" pptx
... JM, Yeagley D, Quinn PG: Assessment of the roles of mi-togen-activated protein kinase, phosphatidylinositol 3-kinase,protein kinase B, and protein kinase C in insulin inhibition of ... phosphorylation of Thr389 in p70 S6kinase was increased in the presence of insulin after 15 min of incubation and remained increased after 16 hours. Rapamycin abolished the phos-phorylation of Thr389 ... initially bindsto the insulin receptor causing autophosphorylation of theβ-subunit of the receptor [8]. The protein kinase domain of the β-subunit then phosphorylates tyrosine residues in in-sulin...
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Báo cáo y học: " The predictive role of serum and bronchoalveolar lavage cytokines and adhesion molecules for acute respiratory distress syndrome development and outcome" doc
... metabolites, inflammatory and anti -in- flammatory cytokines and TNF-α result in increased alveolar-capillary membrane permeability [5,3]. Cytokines are produced in the lung by local resident ... regarding bronchoalveolar lav-age fluid (BALF) [2]. Various inflammatory mediators have been found to be increased in BALF in the early phase of ARDS, including endotoxin-binding proteins, ... in vitro. Immunology 1996, 87:454-46018. Shanley TP, Warner RL, Ward PA: The role of cytokines and ad-hesion molecules in the development of inflammatory injury.Mol Med Today 1995, 1:40-4519....
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Báo cáo y học: "The expanding role of Tax in transcription" pdf
... co-immunoprecipitatedonly the phosphorylated form of RNAP II from HTLV-Iinfected cells. Thus, if only indirectly, Tax may increasekinase activity resulting in enhanced CTD phosphoryla-tion for steps following initiation, ... resulting in the loss of the capping machinery and the association of splicing,elongation and chromatin remodeling factors. In the case of HTLV-I, Tax has been shown not to associate with aCTD kinase ... of splicingmachinery and elongation factors, and release of the cap-ping machinery. Assembly of SWI/SNF factors with Taxdownstream of the elongation phase RNAP II complexremodels chromatin...
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Báo cáo y học: "The contemporary role of blood products and components used in trauma resuscitation" pdf
... 16 of 17Most concerning in recent discussion regarding theuseofrFVIIainthesettingofinjuryisapotentialrolefor this material in magnifying early traumatic coagulo-pathy. Administration of rFVIIa ... cells in vitro and induce expression of adhe sion molecu les in neutrophils and proinflammatory cytokines. Amongproinflammatory cytokines identified are IL-6, IL-8 and TNF-a. Finally, with increased ... outcomesafter injury [99,85,100].ConclusionOur understanding of the coagulopathy of trauma haschanged significantly in recent years. In the setting of under perfusion and significant volume of tissue injury,coagulation...
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Báo cáo y học: "The global landscape of sequence diversity" docx
... variety of organisms [3]are beginning to yield insights into the generation and extent of sequence diversity across life [4-9]. In addition to the con-tinued discovery of apparently novel genes and ... collated into a single group. Forfungi (four taxonomic groups - Ascomycota, Basidiomycota,Glomeromycota and Zygomycota), nematodes (four taxa -Rhabditina, Tylenchina, Spirurina and Dorylaimia) and arthropods/tardigrades ... events in prokaryotes has resulted in thelack of a robustly defined phylogeny and, hence, studies of sequence diversity have largely focused on the identification and characterization of sequences...
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Báo cáo y học: "The differential contribution of tumour necrosis factor to thermal and mechanical hyperalgesia during chronic inflammation" pps
... mechanismleading to the infiltration and the resulting functional role thatDRG macrophages might play in hyperalgesic responses in models of inflammatory disease.Traditionally, macrophage infiltration into ... Bradykininrelease of TNF-alpha plays a key role in the development of inflammatory hyperalgesia. Agents Actions 1993, 38:C7-C9.5. Cunha FQ, Lorenzetti BB, Poole S, Ferreira SH: Interleukin-8 ... 3a), ris-ing to four times the initial level by 7 days after induction of inflammation. In contrast to TNFR1, TNFR2 mRNA was pre-dominantly increased in the ipsilateral DRG. In situ hybridisa-Figure...
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