... B cells. This finding along withhis history of recurrent infection and a family history of dysgammaglobulinemia prompted the decision to inves-tigate the possibility of a Btk mutation. Informed ... Bruton's Tyrosine Kinase in Atypical X-linked Agammaglobulinemia. New England Journal of Medicine1994, 330:1488-91.7. Lin M, Chien Y, Shyur S, Huang L, Chiang Y, Wen D, Liang P, Yang H:De ... variation in X-linked agammaglob-ulinemia phenotype in a three-generation family. Journal of Allergy and Clinical Immunology 1997, 100:702-6.14. Okoh M, Vihinen M: Interaction between Btk TH and...