... [3,9,34,41,44,45,50,54-61]:Osmotic therapy with hyperosmolar agents aimed at loweringICP and reducing brain oedema by drawing water frominfarcted tissue may be detrimental by primarily dehydratingintact brain, contracting ... particular danger of malignant infarction),ReviewClinical review: Therapy for refractory intracranial hypertension in ischaemic strokeEric Jüttler1, Peter D Schellinger2, Alfred Aschoff3, ... thereby (especially in the caseof repeated use) worsening brain tissue shifts [55,59]. In addition, after discontinuing hyperosmolar therapy, reboundeffects may occur [60,63-65].Prolonged hyperventilation-induced...