... musculoskeletal dis-order and a major cause of disability that affects diarthrodialjoints, being characterized by cartilage degradation, accompa-nied by local inflammation and changes in the subchondralbone. ... Natsuizaka M, Ozasa M, Darmanin S, Miyamoto M, Kondo S,Kamada S, Shindoh M, Higashino F, Suhara W, Koide H, Aita K,Nakagawa K, Kondo T, Asaka M, Okada F, Kobayashi M: Syner-gistic up-regulation ... content.Statistical analysisStatistical significance was assessed by two-way analysis of variance followed by a Bonferroni post test and an unpairedStudent's t test for multiple and single comparisons,...