... for 3 and 4.These latter a nalogues had lost the high receptor bindingaffinity of 1 and w ere similarity potent t o hCt, whereas theymaintained the increased in vivo hypocalcemic potency of 1.Similarly, ... hCt,sCt, analogues 1–6 and/ or 1a, 1b, 2a ,and3 a are summa-rized in Table 1. Our findings that 3 and 4, that contain typeIandII¢ b-turn-promoting substitutes, had the samehypocalcemic potency as 1,whereas2, ... [Asp17,Lys21]hCt(1 6–2 2)-NH2(1b) that comprise mainly the lactambridge-containing region 1 6–2 2 of analogues 1, 2 and 3,respectively, and als o a linear control peptide for 1a ,analogue 1b.Conformational analyses by CD:...