Báo cáo y học: " Non-surgical spinal decompression therapy: does the scientific literature support efficacy claims made in the advertising media" potx

... purposes)Chiropractic & OsteopathyOpen AccessDebate Non-surgical spinal decompression therapy: does the scientific literature support efficacy claims made in the advertising media?Dwain M Daniel*Address: ... relating to the efficacy of non-surgical spinal decompression and as a result has methodological short-comings.SummaryThere is very limited evidence in the scientific literature to support the effectiveness ... decompression therapy hasa financial interest in VAX-D technology in Australia [4].These observations raise concern as to the objectivity of the research for spinal decompression. LimitationsAlthough the...

Báo cáo y học: "Assessment of epicutaneous testing of a monovalent Influenza A (H1N1) 2009 vaccine in egg allergic patients" potx

... highly predictive ofsafely tolerating vaccine administration. In the past, influ-enza vaccines have been contraindicated in patients withegg allergy due to the ovalbumin content of the vaccine.However, ... allergy appears to be safe. This study has shown thatalmost all skin tests to the H1N1 vaccine were negativemaking the role of skin testing questionable. Administer-ing the vaccine in a 1 ... they had a convincing clinicalhistory of an IgE mediated reaction to egg ingestion(including symptoms of urticaria, angioedema, cough,other breathing difficulties, wheeze, pruritus, flushing,rhinoconjunctivitis,...

Báo cáo y học: "A web tool for finding gene candidates associated with experimentally induced arthritis in the rat" docx

... QTLs in rat were obtained from the RatMap database [7].These data were originally collected from experimentallyinduced inflammatory arthritis in rat strains susceptible to the following inducing ... containing both the keyword and the word 'arthritis' divided by the total number ofabstracts containing the keyword alone. The relevance indiceswere multiplied by 100 to generate the ... possible, we simply made the QTL database table directly available through a webinterface. In this way, the user can access all QTLs in our data-base by searching for the locus symbol, the chromosomenumber...

Báo cáo y học: "Differential gene expression of bone anabolic factors and trabecular bone architectural changes in the proximal femoral shaft of primary hip osteoarthritis patients" pptx

... purposes)lular matrix, is synthesised only by bone-forming OB cells.OCN is suggested to be involved in the mineralisation processof newly synthesised osteoid [33]. It is incorporated into the bone matrix, ... subsequentlyaccumulated in the mineralised matrix. Increased OPN mayaugment OB synthetic activity by increasing OB longevity andsurface extent of bone formation. Hence, increased OPNmRNA expression in OA may contribute ... contribute to the under-mineralisation in OA [8]. Interestingly, the findings of the present study indi-cated that the ratio of COL1A1/COL1A2 mRNA expressionwas significantly elevated in OA bone...

Báo cáo y học: " Increased expression of matrix metalloproteinase-10, nerve growth factor and substance P in the painful degenerate intervertebral disc" pot

... moredetailed investigation into these pathways, including analysisof enzyme activities, is required to better understand the underlying pathogenesis.Competing interests The authors declare that they have ... whereas in symptomatic IVD degeneration, the pathwayappears to involve the induced or enhanced expression ofboth the neurotrophin NGF and MMP-10.Increases in IL-1 may both directly stimulate the ... activated byAPMA (4-aminophenylmercuric acetate), trypsin or plasmin[19,25,33]. Such potent activation of these proteins cantherefore shift the balance of activity in favour of MMP activityover their...

Báo cáo y học: "Chemokine receptor expression and functional effects of chemokines on B cells: implication in the pathogenesis of rheumatoid arthritis" ppt

... stimulation in the synovium. Taken together, inter-action between chemokine and chemokine receptor mightplay roles not only on B cell migration into the synovium, butalso B cell activation in the synovium. ... in the RA syn-ovium [22-29]. Therefore, interactions between the chemok-ines and the chemokine receptors might contribute to B cellmigration into the synovial tissue in patients with RA. In ... minutes. 3H-thymidine was added and B cells were incubated for 24 hours. The incorporated radioactivity was quantified. Fold increase in 3H-thymidine incorporation in response to chemokine...

Báo cáo y học: "Effect of small interference RNA (siRNA) for ADAMTS5 on intervertebral disc degeneration in the rabbit anular needle-puncture model" pptx

... not ana-bolic. In addition, a possibility remains that the injected siRNAwas retained in the NP area, where the siRNA was injected, bysome mechanism, or mainly internalized by NP cells and ... to the AF area. In a previous study using the rab-bit anular puncture model, the injection of osteogenic protein-1 into the NP induced an increased proteoglycan content ofboth the AF and the ... and interpretation of data. KMparticipated in the design of the study and finalized the manu-script. YK and TK participated in the design of the study andperformed the statistical analysis....

Báo cáo y học: "Galaxy: a comprehensive approach for supporting accessible, reproducible, and transparent computational research in the life sciences" ppsx

... workflow so that the study can be rerun in itsentirety [22]. To reproduce the analyses performed in the study, readers can copy the study’s his tories intotheir own workspace and rerun them. Readers ... by problems rangingfrom tool installation; to d etermining which parametervalues to use; to efficiently combining multiple toolstogether in an analysis chain. The severity of these pro-blems ... andfeel. The Galaxy analysis environment is made possible by the model Galaxy uses for integrating tools. A tool canbe any piece of software (written in any language) forwhich a command line invocation...

Báo cáo y học: "Genome sequence and global sequence variation map with 5.5 million SNPs in Chinese rhesus macaque" potx

... nonsynonymous-SNP-containing druggable domains.To identify the human SNPs within the domainsdetected in macaque, we used 273 gene symbols asqueries to search in the P olyDoms database, which inte-grates all coding ... nonsynonymous SNPs located in 273 unique genes were identified in the druggabledomains (Table S6 in Additional file 3). Meanwhile, todetect whether these SNP-containing druggable domains in the ... contain one ormore SNPs in their coding regions. SNP and nsSNP denote synonymous and non-synonymous SNPs, respectively. OMIM, Online MendelianInheritance in Man.Fang et al. Genome Biology 2011,...

Báo cáo y học: "Glycogen synthase kinase 3, circadian rhythms, and bipolar disorder: a molecular link in the therapeutic action of lithium" docx

... the forefront of the short list of known physiological targets in the therapeutic efficacy of lithium in BPD.Competing interests The author(s) declare that they have no competing inter-ests.Authors' ... whose dysregulation may be involved in the pathophysiology of affective disorders [6]. While there aremany differences in the molecular and genetic details of the circadian machinery in mammals ... Lithium inhibits glycogen syn-thase kinase-3 activity and mimics wingless signaling in intactcells. Curr Biol 1996, 6(12):1664-1668.18. Ryves WJ, Harwood AJ: Lithium inhibits glycogen synthasekinase-3...

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