... stimulation, CD28 expressionincreased significantly in R and AR, and blockade ofCD28 decreased the Th2 cytokine production, indicatingthe involvement of CD28 in Th2 cell activation in allergy. ... production in vivo [14].CTLA-4 is also a CD80/CD86-binding protein. It isup-regulated on activated T cells and deliver s mainly aninhibitory signal, playing an important role in mainte-nance ... of Tlymphocyte cytokine production in induced sputum from asthmatics: aflow cytometry study. Clin Exp Allergy 2003, 33:1238-1243.22. Botturi K, Lacoeuille Y, Thomas P, Boniface S, Reynaud-Gaubert...