Báo cáo y học: "Ingredients for adequate evaluation of blood glucose algorithms as applied to the critically ill" docx

... (non-measured) continuous glucose signal, allowing application of CommentaryIngredients for adequate evaluation of blood glucose algorithms as applied to the critically illTom Van Herpe1, Bart ... measure the quality of blood glucose control inpatients admitted to the intensive care unit. Each indicator can berelated to one or more of the following categories: blood glucose zones, blood ... differentthresholds for BG, varying from <40 mg/dl to <72 mg/dl. Insome studies any measurement below the threshold isregarded ‘hypoglycaemia’, whereas other studies take the time dimension into account...

Báo cáo y học: "Phenotypic and functional characterisation of CD4+ memory T cells homing to the joints in juvenile idiopathic arthritis" pps

... broadlyclassified into two groups: inflammatory and homeostatic[4]. The inflammatory chemokines are induced by proin-flammatory stimuli and control the migration of leukocytes to the site of ... focused on the capacity of memory T cells to differentiate in the context of inflamed tissues. Many of these studies used a member of the tumour necrosis factor receptor family, CD27, to dis-tinguish ... in the study design and helped to draft the manuscript. IP, FM, SC and FF performed the cytofluori-metric analysis and chemotaxis studies. AU performed the enzyme-linked immunosorbent assay for...

Báo cáo Y học: Evidence for general stabilization of mRNAs in response to UV light pdf

... kinase assays with cytoplasmic lysates(Fig. 5B, lower panel). The half-life of endogenous histonemRNA in the cells kept with tetracycline was similar to that of untransfected HeLa cells assayed ... stabilization of endogenous histone mRNA(Fig. 5). Stabilization of ARE-containing reporter mRNAswas also insensitive to the inhibitor, as well as to coexpres-sion of inhibitory mutants of the p38 ... expressing the tetracycline-sensitive trans-activator [25]. The decay of mRNAs expressed with the tet-oﬀ system was followed subsequent to inhibition of theirtranscription by the tetracycline analog...

Báo cáo y học: "Rationale for prostaglandin I2 in bone marrow oedema – from theory to application" potx

... characterising BMEand AVN in the early stages [26]. The success of different treatment concepts is stronglydependent on the stage of the disease, as classified by the Association Circulation Osseous ... promote bone regeneration on a cellular or systemiclevel. The purpose of this study was to assess the curative andsymptomatic efficacy of the prostacyclin analogue iloprost inBME and AVN patients.Method ... which is measured by the release of the neurotransmitter substance P. Nakae and col-leagues [64] showed that the IP antagonist 2-[4-(1H-indol-4-yloxymethyl)-benzyloxycarbonylamino]-3-phenyl-propionicacid...

Báo cáo y học: " support for multiple classes of local expression clusters in Drosophila melanogaster, but no evidence for gene order conservation" pot

... cluster types areunits of evolution, in th e sense that they are domains of preserved synteny, as observed in yeast [8-11]. Consid-eration of rates of synteny preservation needs to control for background ... category of cl usters of house-keeping [21]and/or highly expressed genes [22] in the human gen-ome is likely to b e the equivalent of (or closely related to) similarly sized clusters of the essential ... likely to be artifacts of the underlyingmethod rather than true co-expression clusters. Notonly are a substantial proportion of genes assigned to these clusters presumably irrelevant to the...

Báo cáo y học: "Editorial for inaugural issue of Journal of Brachial Plexus and Peripheral Nerve Injury" doc

... molecularmechanisms.Prior to today's inauguration Journal of Brachial Plexus andPeripheral Nerve Injury, there has been no single, dedicatedplace to discuss these critical issues. We have the opportu-nity to ... this as amotive to produce and foster new scientific thought for the benefit of the community affected by brachial plexusand nerve injury. This is the most exciting concept of all.I look forward ... inall areas of our field and a comprehensive internationaldistribution. There is every reason to expect that we willset new standards for the study of peripheral nerve injuryand in the process...

Báo cáo y học: " Evidence for genetic association of RORB with bipolar disorder" pptx

... and is highest in the eye, pin-eal gland, and brain, particularly in the primary sensorycortices (layer IV of the somatosensory cortex) and the suprachiasmatic nuclei of the hypothalamus (reviewed ... thoseSNPs found to be associated in our study [see Additionalfile 4]. It is therefore necessary to verify these associationresults in other independent samples and to continue to study the relationship ... Hospital, Boston, MA, USA, 2Department of Biology, Indiana University, Bloomington, IN, USA, 3Department of Psychiatry, SUNY Upstate Medical University, Syracuse, NY, USA, 4Laboratory of Neurophenomics,...

Báo cáo y học: "Clinical and serological evaluation of a novel CENP-A peptide based ELISA" pdf

... of SSc patients. Therefore, no infor-mation was obtained for the clinical sensitivity of the peptide based assays. Another limitation of the study was the lack of disease controls to prove the ... CENP-A was used as the template for the commercial synthesis of syntheticpeptides (Peptides & Elephants, Berlin, Germany). The quality and purity of the peptide were assessed by massspectrometry ... reactivity in only oneassay. For example, one sample that was clearly positiveby the CENP-A ELISA (7.0 RU) was negative by the CENP-B ELISA (0.5 RU). Vice versa, another serumclearly positive by the...

Báo cáo y học: " Evidence for preferential copackaging of Moloney murine leukemia virus genomic RNAs transcribed in the same chromosomal site" ppt

... selectively transports the unspliced viral RNAs from the nucleus to cytoplasm [25]. Moreover, unspliced HIV-1 RNAs form a general cytoplasmic pool of moleculeswhich can further participate in the ... vectorspDHEneo and pD∆pbsSVpuro cotransfected into the packaging cell line would be tandemly integrated into the host genome. To study the integration of plasmid DNA, the PCR analysis was performed ... RNAs.Conclusions The results of this study provide evidence that the Mo-MuLV genome is mainly formed from RNA moleculessynthesized on the same DNA-provirus. This property of Mo-MuLV may explain why only small...

Báo cáo y học: " Evidence for horizontal transfer of a secondary metabolite gene cluster between fungi" potx

... are physically organized into gene clusters. Theyfound that the pathway for biotin synthesis was lost in a yeastancestor and then regained in the S. cerevisiae lineage by acombination of HGT ... ACE1 and SYN2 are PKS-NRPS hybridgenes; RAP1 and RAP2 code for enoyl reductases; CYP1-CYP4 for cytochrome P450 monoxygenases; ORFZ for an α/β-hydrolase; OXR1 and OXR2 for oxidoreductases; MFS1 ... in others. The consequences of such a situationcould include the formation of physical gene clusters (to reduce the chances of coding for only part of the pathway, or for strong repression of...

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