Báo cáo y học: "Drotrecogin alfa (activated): real-life use and outcomes for the UK" ppt
Báo cáo y học: "Drotrecogin alfa (activated): real-life use and outcomes for the UK" ppt
... paid for analyses for industry, including EliLilly and Company. All authors are employees of ICNARC.Authors' contributionsKR conceived the study. EN coordinated the study. CW and DH performed ... manuscript. KR had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.References1. Bernard GR, Vincent ... units. The largesample size, for both units and patients, and the basis of actual use of DrotAA (not subject to entry criteria used in the PROW-ESS study) enhance the generalizability of these...
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Báo cáo y học: "Drotrecogin alfa (activated) may attenuate severe sepsis-associated encephalopathy in clinical septic shock" pot
... thatthey have no competing interests.Authors' contributionsHS and DNN conceived the study, and analyzed, interpreted and integrated the data. They also elaborated the manuscript. JT and ... manuscript. JT and LH performed and supervised the enrolment of patients in the study. JS performed the S100Bassay. All authors read and approved the final version of the manuscript.Author Details1Intensive ... investigator for studies sponsored by Eli-Lilly, the manufacturerof drotrecogin alfa (activated), and has received an honorarium from Eli-Lilly for serving as a member of local Advisory Boards. All other...
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Báo cáo khoa học: "Drotrecogin alfa (activated): current evidence supports treatment for severe sepsis patients with a high risk of death" ppsx
... for ADDRESS and PROWESS of 18.17% and 81.83%, respectively; method 2, a random effect model demonstrating a risk ratio usingweights for ADDRESS and PROWESS of 45.35% and 54.65%, respectively; ... R, Levy H, Talwar D, Trzaskoma BL,Francois B, Guy JS, Bruckmann M, Rea-Neto A, et al., for the Administration of Drotrecogin alfa (activated) in Early StageSevere Sepsis (ADDRESS) Study Group: ... ElyEW, et al., for the Recombinant Human Protein C WorldwideEvaluation in Severe Sepsis (PROWESS) Study Group: Efficacy and safety of recombinant human activated protein C for severe sepsis....
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Báo cáo y học: "Intra-articular hyaluronan (hyaluronic acid) and hylans for the treatment of osteoarthritis: mechanisms of action" pps
... othercytokines (e.g. IL-8, IL-6, and leukotriene inhibitory factor),proteases, and prostaglandin E2(PGE2) [30]. Synthesis of the inflammatory cytokines IL-1 and TNF-α and expressionof their ... chondrocytes or the articular cartilage surface in OA [29,31]. The activity ofmany MMPs increases in OA by either an increase in theirown synthesis, an increased activation by their proen-zymes, ... inhibiting the synthesis of colla-gen and PG, enhancing MMP activity, reducing the synthe-sis of an IL-1 receptor antagonist by chondrocytes, and increasing susceptibility to cell injury (i.e....
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Báo cáo khoa học: "Drotrecogin alfa (activated) in patients with severe sepsis presenting with purpura fulminans, meningitis, or meningococcal disease: a retrospective analysis of patients enrolled in recent clinical studies" ppt
... NoNoNoNoYesNoNoNoYesNoDrotAA-related2YesNoNoNoYesYesNoYesNoNoDisease categoryPF Yes Yes No No No Yes Yes No Yes YesMEN No No Yes Yes Yes Yes No Yes Yes NoMD YesNoYesNoNoYesNo NoNoYesBaseline ... infusionDay of event1117810UDUDBleeding eventICH No No No Yes No Yes YesFatal No No No Yes No Yes NoDrotAA related2No No No Yes No No NoDisease categoryPF Yes Yes Yes Yes Yes No YesMEN No Yes ... patients.Competing interestsSBY, VLW, JEB, CLM, SS, SMS, and JMJ are employees of EliLilly and Company. JLV and SN are consultants for Eli Lilly and Company. DJK and RTNG have declared that they have nocompeting...
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Báo cáo khoa học: "Drotrecogin alfa (activated): down and not out, but not really in eithe" ppt
... any case, we believe thatevidence for the routine use of DrotAA should be based onconsistent clinical trials and should not depend on the use of aLetterDrotrecogin alfa (activated): down and ... estimate of the effect of DrotAA for anypatient is the overall pooled result incorporating all patients.Interestingly, although the degree of between-study hetero-geneity is significant when the overall ... between these trials and further minimization ofclinical heterogeneity by selecting a more uniform subgroupof patients with severe sepsis and a high risk of death. Inparticular, for the subgroup...
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Báo cáo khoa học: "Drotrecogin alfa (activated) should not be used in patients with severe sepsis and low risk for death" pdf
... 2001 the United States and European drug regulatory agencies approved DrotAA for use in adult patients with severe sepsis and high risk of death, as defined by an Acute Physiology and Chronic ... greater in the DrotAA group both during the infusion (2.4% vs. 1.2%, P=0.02) and in the 28-day study period (3.9% vs. 2.2%, P=0.01) and were similar to rates seen in the PROWESS trial. There has ... Janes J: Drotrecogin alfa (activated) treatment in severe sepsis from the global open-label trial ENHANCE: further evidence for survival and safety and implications for early treatment. Crit...
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Báo cáo y học: " ncremental cost effectiveness of proton pump inhibitors for the prevention of non-steroidal anti-inflammatory drug ulcers: a pharmacoeconomic analysis linked to a case-control study" potx
... uncertainty we used the extremeestimates for both the most positive and the most negativeoptions for concomitant PPI therapy and NSAID use. The sec-ond approach was used to show the impact of varying ... complication for the group using con-comitant PPIs and the group not using concomitant PPIs.To test the robustness of the results, two approaches wereused. The first one takes the uncertainty of the ... University of Twente, Citadel, 7500 AE Enschede, The Netherlands3Groningen University Institute for Drug Exploration (GUIDE), Department of Social Pharmacy, Pharmacoepidemiology and Pharmacotherapy,...
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Báo cáo y học: "Response to commentary by Dixon and Silman on the systematic review and meta-analysis by Bongartz et al" doc
... malignancy and serious infection? Commentary on the meta-analysis by Bongartz et al. Arthritis Res Ther 2006, 8:111.LetterResponse to commentary by Dixon and Silman on the systematicreview and ... infliximab for partial responders [4]. Thus, notonly are our findings applicable to clinical practice and biologically plausible, but they also fulfill the dose-effectcriterion for causality. The ... Dixon and Silman raise the possibility of bias in our analysis because of the greaterdropout rate in the placebo arm, potentially leading to a lowerdetection threshold for malignancies in the...
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Từ khóa: Báo cáo thực tập tại nhà thuốc tại Thành phố Hồ Chí Minh năm 2018chuyên đề điện xoay chiều theo dạngNghiên cứu tổ chức pha chế, đánh giá chất lượng thuốc tiêm truyền trong điều kiện dã ngoạiNghiên cứu vật liệu biến hóa (metamaterials) hấp thụ sóng điện tử ở vùng tần số THzNghiên cứu tổ chức chạy tàu hàng cố định theo thời gian trên đường sắt việt namđề thi thử THPTQG 2019 toán THPT chuyên thái bình lần 2 có lời giảiGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitQuản lý hoạt động học tập của học sinh theo hướng phát triển kỹ năng học tập hợp tác tại các trường phổ thông dân tộc bán trú huyện ba chẽ, tỉnh quảng ninhPhát triển mạng lưới kinh doanh nước sạch tại công ty TNHH một thành viên kinh doanh nước sạch quảng ninhPhát hiện xâm nhập dựa trên thuật toán k meansNghiên cứu về mô hình thống kê học sâu và ứng dụng trong nhận dạng chữ viết tay hạn chếTìm hiểu công cụ đánh giá hệ thống đảm bảo an toàn hệ thống thông tinSở hữu ruộng đất và kinh tế nông nghiệp châu ôn (lạng sơn) nửa đầu thế kỷ XIXGiáo án Sinh học 11 bài 15: Tiêu hóa ở động vậtGiáo án Sinh học 11 bài 15: Tiêu hóa ở động vậtchuong 1 tong quan quan tri rui roGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtChiến lược marketing tại ngân hàng Agribank chi nhánh Sài Gòn từ 2013-2015HIỆU QUẢ CỦA MÔ HÌNH XỬ LÝ BÙN HOẠT TÍNH BẰNG KIỀM