Báo cáo y học: " Inhibition of Tat activity by the HEXIM1 protein" docx
Báo cáo y học: " Inhibition of Tat activity by the HEXIM1 protein" docx
... reduction of P-TEFb activity, thus the inhibition of Tat activity is unlikely dueto a global reduction of cellular P-TEFb activity. To further investigate the mechanism of inhibition of Tat- mediated ... rescued Tat function, ectopic expression of HEXIM1 effectively inhib-its Tat activity. Most importantly, Tat enhancement medi-ated by hCycT1 was effectively abrogated by co-expression of HEXIM1 ... expression of HEXIM1 resulted in a modest inhibition (2-fold) of P-TEFb activity in vivo. Thus, HEXIM1- mediated inhibition of Tat activity is unlikely due to a global inhibition of P-TEFb activity. Moreover,...
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Báo cáo y học: "Inhibition of NFκB by the natural product Withaferin A in cellular models of Cystic Fibrosis inflammation" pps
... The KKLEB immortalized CFairway cell line homozygous for ΔF508 mutation and the CF 14 clinically isolated mucoid strain of PA (originallyfrom the laboratory of Dr. M.C. Wolfgang, University ... http://www.journal-inflammation.com/content/6/1/15Page 4 of 5(page number not for citation purposes)fashion by ~70% in the KKLEB cells. Inflammation in CFis regulated largely by activation of NFκB and transcrip-tion of pro-inflammatory genes ... stud-ies of WFA using medicinal chemistry may lead to com-pounds that inhibit NFκB activity without undesirableside effects. Further, targeted delivery of anti-NFκB agentsto the airways of CF...
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Báo cáo y học: "Inhibition of neutrophil activity improves cardiac function after cardiopulmonary bypass" pot
... after end of surgery the distribu-tion of the labeled neutrophils was analyzed by scintigra-phy (Figure 6). In Figure 6A an example for the total bodydistribution of radioactivity is provided. ... AbstractBackground: The arterial in line application of the leukocyte inhibition module (LIM) in the cardiopulmonary bypass (CPB) limits overshooting leukocyte activity during cardiac surgery. Westudied ... cardiopulmonary bypass The investigation conforms to the Guide for the Care andUse of Laboratory Animals published by the US NationalInstitutes of Health (NIH Publication NO. 85-23, revised1996). The...
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Báo cáo y học: " Regulation of Sox9 activity by crosstalk with nuclear factor-κB and retinoic acid receptors" pptx
... effect of TNF-α on Sox9 activity. Finally, the sensitivity of Sox9 to atRA was reduced by caMEKK1 expression. Thus, the activity state of p300, the common co-factor and MEKK1 target, probably plays ... atRA.Regulation of transcription factor activity by p300Differences in the affinity for p300 may contribute to the pat-tern of regulation of transcription factor activity observed in the present study. ... is controlled not only by rela-tive affinity but also by relative stoichiometry of the transcrip-tion factors activated in the nucleus.Manipulating the acetylase activity of p300 can reveal...
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báo cáo khoa học: " Inhibition of telomerase activity by HDV ribozyme in cancers" ppsx
... 30:1http://www.jeccr.com/content/30/1/1Page 7 of 7and the effects of developing the HDV ribozyme as atool of cancer gene therapyMethods The bel7402, HCT116 cells were given by Department of molecular Biology, Shandong University, DNA ... DNA of HDV ribozyme was synthesized by Shanghai BiosunSci&Tech. Co. LTD. Recombinant plasmid pBBS212containing hTR gene was provided by Geron Company.Design and synthesis of HDV ribozymeIt ... Structure of antigenomic ribozyme of HDV (g.RZ 1/84).Figure 2 The secondary stru cture of HDV ribozyme annealedto the hTR, the target site GUC is just above the arrow, the arrow indicates the site of...
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Báo cáo y học: " Modulation of microtubule assembly by the HIV-1 Tat protein is strongly dependent on zinc binding to Tat" pptx
... increased the turbidity plateau by about two-fold over the control (in the absence of Tat) . Electronmicroscopy data as well as the reversibility of the majorpart of the holo -Tat- induced turbidity ... conformations of the apo-form and zinc-boundform of Tat, and studied the interaction of the two forms of Tat with tubulin. The 86-aa-long Tat protein was syn-thesized by solid-phase chemistry and was ... constitutes the active form of Tat in the cell cytoplasm. By altering the microtubuledynamics, holo -Tat may then lead to a release of the pro-apoptotic Bim protein, leading to apoptosis through the mitochondria...
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Báo cáo y học: "Inhibition of early steps in the lentiviral replication cycle by cathelicidin host defense peptides" pptx
... and cells were lysedin 50 µl of cell lysis buffer (Promega, Pittsburgh, PA). 20µl of the cell lysates were used in the firefly luciferase assaysystem of Promega as described by the manufacturer. ... infectivity,whereas the reduction of luciferase activities observed at high concentrations of the other HDPsis primarily due to modulation of cellular activity and/ or cytotoxicity rather than ... parallel by incubating 293A target cells stably transduced with a luciferase gene with the indicated amounts of HDP. The luciferase activity is expressed as percentage of the luciferase activity of...
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Báo cáo y học: " Inhibition of HIV derived lentiviral production by TAR RNA binding domain of TAT protein" pps
... havefound that the TAT PTD and the TAR RNA bindingdomain are located in the same region of the TAT protein. The close proximity of these two properties led us tohypothesize that the sequence of this ... on TAT activated LTR-Luciferase activity and specific TAR RNA binding by Tat- PFigure 6Inhibitory effect of Tat- P on TAT activated LTR-Luciferase activity and specific TAR RNA binding by Tat- P. ... vectors by Tat- P was observedFigure 4No inhibition of third generation lentiviral vectors by Tat- P was observed. To test that the Tat- P inhibition activity is specifically targeting HIV TAT protein,...
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Tài liệu Báo cáo Y học: Inhibition of the MEK/ERK signaling pathway by the novel antimetastatic agent NAMI-A down regulates c-myc gene expression and endothelial cell proliferation ppt
... Such a hypo-thesis is further confirmed by the observation that, differ-ently from the effect of serum, the stimulatory effect of PMA on ERK1/2 activity could also be totally abolished by NAMI-A. ... integrity and equal loading. The levels of radioactivity incorporated into c-myc product werenormalized by comparison with the levels of radioactivityincorporated into the GAPDH product from the ... signaling and that the activation of ERK by GPCRs closely parallels thatemployed by RTK [33]. On the whole, these observationssuggest that the inhibitory effect elicited by NAMI-A onERK signaling...
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Tài liệu Báo cáo Y học: Inhibition of nuclear pre-mRNA splicing by antibiotics in vitro pot
... 2). The sixfold stron gersplicing inhibition by Cl-tetracycline may be explained by the a dditional s ize and hydrophobicity introduced by the substitution, as is often the case in ribozyme inhibition ... of chlorine for hydrogen at position 7 (Fig. 1C). Inhibition by Cl-tetracycline w as found to be sixfold more t han by tetracycline (Fig. 2). The extent of splicing inhibition by tetracycline is n ... (1995) Inhibition of the hammerhead ribozyme by neomycin. RNA 1, 95±101.32. Earnshaw, D.J. & Gait, M.J. (1998) Hairpin ribozyme cleavagecatalyzed by aminoglycoside antibiotics and the polyamine...
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