... that pain fibers can be identified in the synovium, in ligaments especially near their insertions, in bone, in muscle, and in the outer third of the meniscus in the knee. In an unusual study in which ... tofurther damage and malalignment within the joint duringmovement. Either malalignment or local stepoffs within the joint subject the cartilage (both fibro and hyaline) to excessfocal loading, ... Synovitis-induced inflammatorychanges within the joint may, in turn, have effects onperipheral nervous system inputs at the spinal cord level,inducing both peripheral and ultimately central...