... entriesacid–base, 2 0–2 3 enzyme, 4 1–4 3, 4 8–5 2, 5 2–5 3 in mechanism-based inhibition, 15 8–1 59models of, 4 8–5 2pH dependence of, 7 9–8 9practical example of enzyme, 5 3 5 8Catalysts, enzymes as, 4 1–4 3 Catalytic ... INDEXAbbreviations, table for mutation research,21 4–2 16Absolute reaction rate theory, 2 3 2 6Acid–base catalysis, 2 0–2 3 Acidity constant (K a ), 2 0–2 1Activation, 1 03 Activation curves, 20 0–2 02. ... 166Reactant concentrationas function of time, 3 enzyme stability and, 14 6–1 50in integrated rate equations, 4–1 2transient phases and, 13 2–1 35 Reaction half-life, 1 1–1 2, 14 2–1 43 Reaction mechanisms,...