Báo cáo y học: "Endogenous TGF-β activation by reactive oxygen species is key to Foxp3 induction in TCR-stimulated and HIV-1-infected human CD4+CD25- T cells" docx
Báo cáo y học: "Endogenous TGF-β activation by reactive oxygen species is key to Foxp3 induction in TCR-stimulated and HIV-1-infected human CD4+CD25- T cells" docx
... implicated in the induction of Tregs in murine cells, we set out to investigate whether TGF-β has a role in the unexpected induction of Tregs by TCRstimulation in human T cells. In the human immune system, ... of latent TGF-β by reactive oxygen species generated from theactivated T cells. Biologically active TGF-β then engages in the induction of Foxp3. Neutralizationof active TGF-β with anti -TGF-β ... here that endogenous TGF-β is key to TCR induction of Foxp3 in human CD4+CD25- T cells. These events involve, first, the production of TGF-β by TCR and CD28stimulation and the activation...
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Báo cáo y học: "Suppression of inflammation by low-dose methotrexate is mediated by adenosine A2A receptor but not A3 receptor activation in thioglycollate-induced peritonitis" pps
... respond to methotrexate therapy.IntroductionLow-dose weekly methotrexate has become the mainstaytreatment of rheumatoid arthritis and psoriasis, and it is thegold standard by which other systemic ... IL-10, and IL-12 [23,25-27,47]. In addition to the regulatoryeffect of adenosine in cytokine secretion, we have furtherestablished that Th1 proinflammatory cytokine IL-1 and TNF-αtreatment increases ... McCrary CT, CronsteinBN: Reversal of the antiinflammatory effects of methotrexate by the nonselective adenosine receptor antagonists theophyl-line and caffeine. Evidence that the antiinflammatory...
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Báo cáo y học: "Aerosolised surfactant generated by a novel noninvasive apparatus reduced acute lung injury in rats" doc
... pulmonary surfactant (PPS) in the nebuliser is converted to an aerosol by the jetting power of oxygen. (b) An anesthetised rat is placed in the plastic container and allowed to inhale the PPS ... sur-factant may not only prevent the lung from oedema by stabilis-ing the fluid system in the lung, but may also inhibit theinflammatory response [28]. In this study, we showed a thera-peutic ... Research Laboratories, University Health Network, Toronto General Research Institute and Department of Surgery, Faculty of Medicine, University of Toronto, TMDT/MaRS East Tower – 13th Floor, Room...
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Báo cáo y học: "A functional variant of Fcγ receptor IIIA is associated with rheumatoid arthritis in individuals who are positive for anti-glucose-6-phosphate isomerase antibodies" doc
... theFcγRs.IntroductionRheumatoid arthritis (RA) is a heterogeneous autoimmune dis-ease that is characterized by chronic inflammatory polyarthritis[1]. One of the characteristic features of RA is the ... susceptibility to rheumatoid arthritis. Arthritis Rheum 2000, 43:735-739.16. Matsumoto I, Staub A, Benoist C, Mathis D: Arthritis provoked by linked T and B cell recognition of a glycolytic enzyme. ... regulated by somegenes, especially by FcγR genotype, as well as by productionof arthritogenic autoantibodies.Competing interestsThe author(s) declare that they have no competing interests.Authors'...
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Báo cáo y học: "Rheumatoid arthritis seropositive for the rheumatoid factor is linked to the protein tyrosine phosphatase nonreceptor 22-620W allele" docx
... analysis showed that itaffects the binding of LYP to Csk, leading to a lack of down-regulation of T- cell activation, which is consistent with anincreased susceptibility to autoimmunity for the ... respectively, 5'-GATAATGTTGCT-TCAACGGAATTT-3' and 5'-CCATCCCACACTTTATTT-TATACT-3'. The PTPN22-1858C /T transition at codon 620eliminates a restriction site for RsAI in the 185 8T ... studywas to test this PTPN22 polymorphism for linkage to RF+ RA in the French Caucasian population, taking advantage of theTDT.Patients and methodsStudy design and study populationA TDT linkage...
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Báo cáo y học: "Use of WHO clinical stage for assessing patient eligibility to antiretroviral therapy in a routine health service setting in Jinja, Uganda" pdf
... underestimate since we measured thisonly in subjects in whom ART was initiated. This group ofsubjects will be at increased risk of progressing to disease and transmitting the virus [10,11] and testing ... findings suggesting significantrisk to patients with CD4 counts above 200 × 106/l [12].Our study highlights the urgent need for greater CD4count testing prior to the initiation of ART to ... prior to initiation of ART to accompany the roll-out of ART.Introduction In developed countries, CD4 count and plasma viral loadtesting are essential for monitoring HIV-infected subjectsand...
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Báo cáo y học: "Acute mucosal pathogenesis of feline immunodeficiency virus is independent of viral dose in vaginally infected cats" pptx
... addressed in acute pathogen-esis, with particular attention t o innate immunity.Further, we identified the intestinal mucosa as a verysensitive indicator of retroviral infection that is indepen-dent ... Collectively,these findings suggest that mucosal lymphocy tes are themost sensitive indicator of infection as they are dis-rupted regardless of initial viral dose and seroconversionstatus, indicating that ... exposed and seronegative. As postulated by several authors and supported by our results, occultor latent infection, controlled by innate and cell-mediated immunity may occur more frequently in highly-exposed...
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Báo cáo y học: "Cost-effectiveness analysis of clinical specialist outreach as compared to referral system in Ethiopia: an economic evaluation" pot
... collectors were trained by theprincipal investigator prior to the data collection period.The data collection tools include: Clinical Specialistoutreach visit details sheet, Clinical specialist ... results of this study showed that a total of 23 clini-cal specialist outreach visits were made in 21 visits to thefour hospitals. During these visits a total of 139 specialistdays (calculated ... served by nearby hos-pitals at a cost which is equivalent to the amount theypaid to get the services through referral.Sensitivity analysisExclussion of results due to the on the jobs training...
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Báo cáo y học: "An updated study-level meta-analysis of randomised controlled trials on proning in ARDS and acute lung injury" pps
... primary trial heterogene-ity by a subgroup meta-analysis of studies that restrictedinclusion to only ARDS. This meta-analysis shows thatprone ventilation significantly reduces ICU mortality in ARDS ... significant reduction in mortality in the studies that restricted inclusion to only patientswith ARDS, and not in those also enrolling patients withless disease s everity. The comparison of the mean ... criteria are sobroad that a certain amount of diversity among studies is inevitable. A study-level meta-analysis should antici-pate this diversity and interpret the findings according to the...
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Báo cáo y học: "The TGF-beta-Pseudoreceptor BAMBI is strongly expressed in COPD lungs and regulated by nontypeable Haemophilus influenzae" doc
... the TGF receptors I and IIwhich may be prevented by interaction of the cytokinewith the pseudoreceptor [12]. This mechanism may influ-ence TGF signalling besides other known activation and signalling ... of NTHI-mediated induction of proinflammatory cytokines and inhibition of TGF-β expression may influence inflammation induced tissue remodeling.IntroductionPulmonary presence of nontypeable ... eval-uated using lung tissue obtained from COPD patientswithout evidence of acute infection.Subjects and methodsStudy protocolNTHI infection in lung tissues obtained from COPDpatients and controls...
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Từ khóa: Nghiên cứu sự biến đổi một số cytokin ở bệnh nhân xơ cứng bì hệ thốngchuyên đề điện xoay chiều theo dạngNghiên cứu tổ hợp chất chỉ điểm sinh học vWF, VCAM 1, MCP 1, d dimer trong chẩn đoán và tiên lượng nhồi máu não cấpNghiên cứu tổ chức chạy tàu hàng cố định theo thời gian trên đường sắt việt namđề thi thử THPTQG 2019 toán THPT chuyên thái bình lần 2 có lời giảiGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitQuản lý hoạt động học tập của học sinh theo hướng phát triển kỹ năng học tập hợp tác tại các trường phổ thông dân tộc bán trú huyện ba chẽ, tỉnh quảng ninhPhối hợp giữa phòng văn hóa và thông tin với phòng giáo dục và đào tạo trong việc tuyên truyền, giáo dục, vận động xây dựng nông thôn mới huyện thanh thủy, tỉnh phú thọThơ nôm tứ tuyệt trào phúng hồ xuân hươngSở hữu ruộng đất và kinh tế nông nghiệp châu ôn (lạng sơn) nửa đầu thế kỷ XIXChuong 2 nhận dạng rui roNguyên tắc phân hóa trách nhiệm hình sự đối với người dưới 18 tuổi phạm tội trong pháp luật hình sự Việt Nam (Luận văn thạc sĩ)Giáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtBÀI HOÀN CHỈNH TỔNG QUAN VỀ MẠNG XÃ HỘIMÔN TRUYỀN THÔNG MARKETING TÍCH HỢPTÁI CHẾ NHỰA VÀ QUẢN LÝ CHẤT THẢI Ở HOA KỲ