... han by tetracycline (Fig. 2). The extent of splicing inhibition by tetracycline is n egligible (Fig. 2). The sixfold stron gersplicing inhibition by Cl-tetracycline may be explained by the a ... antibiotics (the aminoglycoside,kanamycin, the a minocyclitol glycoside, streptomycin, t hepenicillins, ampicillin and penicillin G, the aminocyclitol,spectinomycin, tetracycline and Cl-tetracycline, ... with the binding o f the functional sub strate.Type-II binding sites are the central metal ion-binding pock-ets i n the catalytic cores of ribozymes. In type-II bindingsites the aminoglycosides...