Báo cáo y học: " Enhanced macrophage tropism of HIV in brain and lymphoid tissues is associated with sensitivity to the broadly neutralizing CD4 binding site antibody b12" ppsx
Báo cáo y học: " Enhanced macrophage tropism of HIV in brain and lymphoid tissues is associated with sensitivity to the broadly neutralizing CD4 binding site antibody b12" ppsx
... proximal to the CD4 binding site, increasedresistance to b12 neutralization [22]. However, the HIV Enhanced HIV entry into macrophages is associated with sensitivity to neutralizing mAb b12 and a broadly ... between enhanced HIV entry intomacrophages and increased sensitivity to reagents target-ing the CD4 binding site. Here, we use a panel of viruses expressing primary HIV Envs from brain and lymphoid ... neutralization sensitivity to sCD4 and mAbs b12 and b6, which recognize neutralizing and non -neutralizing epitopes overlapping the CD4 binding site [24], respectively, and a broadly- neutralizing HIV- infected...
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Báo cáo y học: "Frequent CXCR4 tropism of HIV-1 subtype A and CRF02_AG during late-stage disease - indication of an evolving epidemic in West Africa" docx
... with predetermined subtype and coreceptor tropism. Subtype was determined by sequencing of the env V3region, and coreceptor tropism was determined using aphenotypic infection assay with either ... the HIV- 1 coreceptor tropism of subtype AandCRF02_AG.Usingthisassaywefoundahighamount of HIV- 1 CXCR4-using populations (79%) in our plasma samples and an increasing frequency of CXCR4 tropism ... contribute to the development of genotypic rules and bioinformatic tools for prediction of coreceptor tropism of HIV- 1 CRF02_AG. HIV- 1 subtype determination w as done by amplifying and sequencing the...
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Báo cáo y học: "Anti-cyclic citrullinated peptide antibodies in primary Sjögren syndrome may be associated with non-erosive synovitis" ppt
... (9%), systemic lupus erythematosus (14%), systemicsclerosis (13%), polymyositis/dermatomyositis (14%), and SSTable 3Correlations with clinical and laboratory parameters of anti-CCP antibody- positive ... partic-ipated in drafting the manuscript. NL participated in the analy-sis and interpretation of data. EB and FB-P contributed to the acquisition of data. RC contributed to the interpretation of data and ... non-erosive polyarthropathy affect-ing mainly the small joints, and usually mild synovitis are com-mon in patients with pSS and may mimic RA, particularly in the presence of RF [2,3,18], although the...
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Báo cáo y học: "Triggering receptor expressed on myeloid cells-1 expression on monocytes is associated with inflammation but not with infection in acute pancreatitis" pdf
... infection or inflammation) and HLA-DR on monocytes, and the serum concentrations of IL-6 (a proinflammatorycytokine) and IL-10 in patients with AP to determine whetherthese markers can identify patients ... response syndrome and then by the compensatory anti-inflammatory responsesyndrome, which is defined by low human leukocyte antigen(HLA)-DR expression on monocytes, increased concentration of the ... Christmas S, Neoptolemos JP,Slavin J: Inflammatory mediators in acute pancreatitis. J Pathol2000, 190:117-125.9. Isenmann R, Beger HG: Natural history of acute pancreatitis and the role of infection....
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Báo cáo y học: " Enhanced self-renewal of hematopoietic stem/progenitor cells mediated by the stem cell gene Sall4" doc
... Sall4 isoforms is capable of enhancing and sup-porting primitive hematopoietic cells in the presence of combined cytokine stimulations. Enhanced HSC/HPC activity by forced expression of Sall4isoformsNext, ... Sall4isoforms dramatically stimulate multiple known HSCregulators, such as Notch1, HOXB4, cMyc, CyclinD1,CyclinD2, Bmi1, Nfya, Runx 1and Meis1. This is of greatinterest since all of these factors ... d to elucidate whether it may also function as a master con-troller in modulating genetic networks within the HSCsystem.Another discovery is the finding of how overexpressi on of Sall4 isoforms...
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Báo cáo y học: "Enhanced effector function of cytotoxic cells in the induced sputum of COPD patients" doc
... predominantly Th1-type cytokines [21-24],which could influence t he cytokine milieu within the lung to one which is pro-inflammatory. Interestingly, nodifference in cytotoxic ability of the three ... rs and function within the airways. Therefore, in this study we have extended the findings of our previous study to investigate, withininduced sputum, the number and cytotoxic function of the ... analysis according to their forward and side scatter characteristics.Cytotoxicity assayA commercially available lactate dehydrogenase (LDH)kit (CytoTox 96 Non -Radioactive Cytotoxicity Assay,Promega)...
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Báo cáo y học: "An unusual case of gout in the wrist: the importance of monitoring medication dosage and interaction. A case report"
... joint [2,4,14]. Gout may occur in any joint including the ankle, knee, hand, wrist, elbow,sacroiliac joint and other joints of the spine, howevermost commonly occurs in the lower extremity. In ... bony erosions at the radial styloid process and the dorsal rim of the distalradius with soft tissue swelling. These findings weredeemed to be consistent with gouty arthritis. (See figure1). The ... xanthomatosis, and amyloidosis. The definitive diagnosis of gout is made by examination of synovial fluid aspirated from the joint. Joint aspiration is of prime importance in order to rule out infection.ConclusionThis...
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Báo cáo y học: "Segment-orientated analysis of two-dimensional strain and strain rate as assessed by velocity vector imaging in patients with acute myocardial infarction"
... of the peak systolic longitudinal strain between segments with LE ≥ 51% and LE 1-50% 15. By using the previously proposed cut-off value 15 for strain of –6.5 % a sensitivity of 23 % and ... criticize the intra-individual comparison instead of considering a control group. In our opinion, as the infarct is a regional process, there is no better match than the non-infarcted segment of the ... Discussion The main finding of this study is the significant difference of strain, SRe and tissue velocities between infarcted and non-infarcted segments demonstrated by an comparison between...
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Báo cáo y học: "A severe coarctation of aorta in a 52-year-old male: a case report"
... Diagnosis is usually based on clinical suspicion and physical findings3. The latter include blood pressure differenc e between the upper and lower extremities, pulse delay and systolic murmur ... Ascending aortography Figure 2 Descending aortography Discussion Aortic coarctation is a congenital vascular lesion typically diagnosed in early life, accounting for 5 to 10% of all ... severity and patient’s age at the time of cor-rection. Death in these patients is usually due to heart failure, coronary artery disease, aortic rup-ture/dissection, concomitant aortic valve disease,...
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Báo cáo y học: "Sustained High Quality of Life in a 5-Year Long Term Follow-up after Successful Ablation for Supra-Ventricular Tachycardia. Results from a large Retrospective Patient Cohort"
... Symptoms leading patients to therapy: X-axis: Symptoms in declinary order. (1) Overall symptoms with- out specification, (2) tachycardia, (3) increase of episodes over the years, (4) anxiety, ... about the nature and quantity of tachycardia and the associated symptoms. Further-more, the effect of symptoms on the patients` daily and social life, especially with respect to abstinence ... Prior to interventional therapy, patients mainly suffered from symptoms like tachycardia, increasing incidence of episodes over time, reduction in physical work ca-pacity, dyspnea and angina...
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