... importance of thismotif in the NLPs. The other candidates, 1f51, 1ixm and2ftk present the sequence ghsrhdwm in the middle of anα-helix and for that they were discarded. Further, all the proteins ... positioning of the histidinesenabling them to act as ion ligands [23]. For the position-ing of these motifs in the 2d-structure or relative to the other β-strands, see Figure 2, last line. These ... pattern and, the substitution of any of these residues will reduce the ability of the proteinto hold the metal ion, as is the case in some cupins. Weconcluded that the first motif in the cupins...