... Lawrence (American Red Cross, Rockville, MD,USA): PAI -1 containing a mutation of Gln123 to Lys (PAI-1K) has a specific defect in VN binding; PAI -1 containing a mutation of Arg340 to Ala (PAI- 1A) binds ... Blocking ligand occupancy of the alphaVbeta3 integrin inhibits insulin-like growth factor Isignaling in vascular smooth muscle cells. Proc. Natl Acad. Sci.USA 95, 11 217 11 222. 14 . Persad,S.,Attwell,S.,Gray,V.,Mawji,N.,Deng,J.T.,Leung,D., ... demonstration of the interaction between PAI -1 and the insulin signaling,through the ability of PAI -1 to interact with VN/avb3system.Using different mutants of PAI -1, we have demon-strated that the...