Báo cáo y học: "Hemofiltration, adsorption, sieving and the challenge of sepsis therapy design" ppsx
Báo cáo y học: "Hemofiltration, adsorption, sieving and the challenge of sepsis therapy design" ppsx
... 30–32% for polyamide and AN69, and of 0% for cellulose acetate and polysulfone. IL-1 adsorptionCommentaryHemofiltration, adsorption, sieving and the challenge of sepsis therapy designPatrick ... sepsis. Hemofiltration has been proposed as a therapy for sepsis based on its ability to remove circulating IM by sieving orby adsorption, or both. Designing devices and methods for sepsis therapy ... proposed as a therapy for sepsis based on its ability to remove circulatinginflammatory mediators by sieving or by adsorption, or both. Designing devices and methods for sepsis therapy will require...
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Báo cáo y học: "Hypoxia-inducible factors and the prevention of acute organ injur" ppsx
... since they are rapidly hydroxylated by oxygen-dependent HIF prolyl-4-hydroxylase domain enzymes (PHD), subsequently captured by the ubiquitin ligase Von-Hippel-Lindau protein (VHL), and degraded ... cross-talk of HIF and other key regulators of gene expression (STAT, p-300 and others), further modifi cation of HIF-α activity at the level of DNA hypoxia-responsive elements by small ubiquitin-like ... kidney injury, it may play a role in the progression of chronic kidney disease and certainly is an important factor in the promotion of renal malignancy [3,20].Diverse characteristics and distribution...
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Báo cáo y học: "HLA-DR regulation and the influence of GM-CSF on transcription, surface expression and shedding
... bbiiooggrraapphh y y Sara Perry obtained her BSc in Microbiology and Immunology from University of Leeds, and PhD in Immunology from University of Liverpool, where she worked on the expression of HLA-DR ... expression of both the percentage of monocytes expressing HLA-DR and the density of HLA-DR expression have been observed as a feature of sepsis [4;5;7;8;22-25]. Only recently have the possible ... mentioned otherwise]. Both the percentage of cells expressing HLA-DR on monocytes and the density of HLA-DR was measured. Immuno-fluorescent microscopy of HLA-DR in PBMC Cytospins of PBMC obtained...
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Báo cáo Y học: Changes in ultrastructure and the occurrence of permeability transition in mitochondria during rat liver regeneration ppt
... in the mitochondrial and cytosolic fractions, and in the whole liver homogenate. The enzyme activity of mitochondrial AAT in the cytosol wasdetermined as described by Greco et al. [16]. Brie y, ... PH, the activities of the enzymesreleased in the supernatant (1.8 ± 0.1 and 0.8 ± 0.04% of the total mitochondrial activity of GDH and AAT,respectively), were as low as those found in the supernatantFig. ... wascalibrated by addition of standard aliquots of Ca2+to the medium. A standard curve was obtained from the pooledresults of five independent series of determinations and usedfor analysis of mitochondrial...
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Báo cáo y học: "Oxygen-sensing mechanisms and the regulation of redox-responsive transcription factors in development and pathophysiology" ppsx
... machinery, allowing the formation of glutathione (GSH) by the action of the rate-limiting enzyme, γ-glutamylcysteine synthetase (γ-GCS). The activity of γ-GCS is irreversibly blocked by L-buthionine-(S,R)-sulfoximine ... death, on the other hand, is relatively quick and violent, characterized by the swelling of the cytoplasm, the rupturing of cell membranes, the dilation of the mito-chondria and the disintegration ... airway epithelium can adversely affect its normal physiology and regulatory processes [6,7]. The major functions of the airway epithelium include the following: i) it is a dynamic physiological...
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Báo cáo y học: " Horizontal gene transfer and the evolution of transcriptional regulation in Escherichia col" ppt
... considered other characterizedTFs and putative, as yet uncharacterized regulators. We ana-lyzed the history of each of the global regulators, and of a sam-ple of each of the other types of regulators ... grows more rapidly than the size of the network. However, because only 13% of the TFs evolvedby duplication within the E. coli lineage, and because the majority of the regulatory similarities ... [17].Phylogeny of the γ-ProteobacteriaFigure 2Phylogeny of the γ-Proteobacteria. The phylogeny was derived from concatenated alignments of highly conserved proteins (see Materials and methods)....
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Báo cáo y học: "Global nucleosome distribution and the regulation of transcription in yeas" doc
... occupancy is either the cause or the result of the transcriptional status of a gene. This raises an important question: what are the determi-nants of nucleosome occupancy, and how do they relate ... regulatory regions of the yeast genome have a lower density of nucleosomes than other regions, and that there is an inverse correlation between nucleosomedensity and the transcription rate of a ... segregation of intergenic regions of the genome into the aqueous phase.Nagy et al. [13] proposed that this may be a result of differentefficiency of chromatin cross-linking along the genome and that these...
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Báo cáo y học: " Can ‘permissive’ hypercapnia modulate the severity of sepsis-induced ALI/ARDS" doc
... pulmonary sepsis, suggesting that the eff ects of hypercapnic acidosis depend not only on the stage of the infective process, but also on the site of the primary infection.Early systemic sepsis Hypercapnic ... issues underline the importance of understanding the eff ects of hypercapnia on the immune response, and the implica-tions of these eff ects in the setting of sepsis. Hypercapnia and the innate immune ... regarding the safety of hypercapnia in the setting of prolonged pneumonia, particularly in the absence of eff ective antibiotic therapy. Figure 2. Potential mechanisms underlying the e ects of hypercapnic...
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Báo cáo y học: "Lifetime health effects and medical costs of integrated stroke services - a non-randomized controlled cluster-trial based life table approach"
... risk of recurrence, case-fatality rate of stroke, probability of dis-ability after stroke, and the four probabilities of death -affect patients’ courses in the same way as they did in the original ... performed the analysis and drafted the manuscript. JvE provided data and details on the EDISSE study and edited the draft manuscript. MD helped with the clinical aspects of the model and effectiveness ... cost-effectiveness studies: The usefulness of the Barthel Index and the EuroQoL-5D. Quality of Life Research 2004,13:427-433.22. Mahoney FI, Barthel DW: Functional Evaluation: The Barthel Index. MdState...
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