Báo cáo y học: "Hypothermia and neurologic outcome in patients following cardiac arrest: should we be hot to cool off our patients" pot

... likely to affect the initial ischemic processes. Thus, early hypothermiais likely to be more effective than delayed hypothermia. In arat model, delays of 15 min and 30 min preserved thebeneficial ... within 7 days or hematological instabilityOutcomes Hypothermia: favorable outcome in Hypothermia: favorable outcome in 75 patients (55%) 21 patients (49%)Normothermia: favorable outcome in ... Elevations in heat shockprotein-70 in the hippocampus are blunted byhypothermia [17]. Additionally, arachidonic acid productsmay be involved in an inflammatory cascade, affecting cellsurvival. In...

Báo cáo y học: "Prediction of hospital outcome in septic shock: a prospective comparison of tissue Doppler and cardiac biomarkers" pdf

... troponin [26] potentiallyoffer prognostic information in the critically ill. To date,no comparison has been made between TDI and cardiac biomarkers (BNP, NTproBNP and troponin) with regard to ... of the B-type natriuretic peptidemRNA in cardiac myocytes by alpha-adrenergic receptor activation:potential roles for protein kinase C and mitogen-activated proteinkinase. Mol Endocrinol 1996, ... study day (fluid balance).Vasopressor/inotropic infusion rates and, ICU and hos-pital length of s tay and outcome were recorded. Illnessseverity was quantified using (Acute Physiology and Chronic...

Báo cáo Y học: Structural and compositional changes in very low density lipoprotein triacylglycerols during basal lipolysis potx

... role in hydrolysis of triacylgly-cerol species with these fatty acids. It has been shownthat the hydrolysis of 20:4 containing triacylglycerol and diacylglycerol was slower in rat postheparin ... tria-cylglycerol is used in VLDL triacylglycerol synthesis. Therewere differences also in the sn-1,2-diacylglycerols betweenVLDL and liver triacylglycerol in Triton-treated ratssuggesting that ... positional and fatty acid specificity in vitro.Ifthere were specificity in basal lipolysis in vivo, triacylglycerolcompositions ofcirculating and newly secreted VLDL would be different. To study this we...

Báo cáo y học: "Risk and resiliency factors in posttraumatic stress disorder" pptx

... violently as-saulted than men (such as being beaten up or mugged),they are much more likely to be sexually assaulted, includ-ing being raped. Men, on the other hand, are more likely to have been in ... thisstudy, being female, separation from parents in child-hood, and family and personal history of psychopatholo-gy were significant predictors of PTSD.Coping FactorsCoping has been defined ... nature and in- tensity of the traumatic experience and may be hinderedby the negative consequences of PTSD symptomatologysuch as avoidance behaviour.Relationship Between PTSD and Early EnvironmentThe...

Báo cáo y học: "Angiogenic and angiostatic factors in systemic sclerosis: increased levels of vascular endothelial growth factor are a feature of the earliest disease stages and are associated with the absence of fingertip ulcers" doc

... factor hypoxia inducible factor 1[31]. In addition, a variety of cytokines (e.g. interleukin-1,transforming growth factor beta and platelet-derivedgrowth factor) known to be upregulated in ... B, Weiner S, MartinR, Weinstein A, Weisman M, Mayes M, Collier D: Inter and intraobserver variability of total skin thickness score (modi-fied Rodnan TSS) in systemic sclerosis. J Rheumatol ... of SSc patients includedangiotensin-converting enzyme inhibitors, calcium channelblockers, proton-pump inhibitors, clebopride and topicalglyceryl trinitrate. Patients with pre-SSc were treated...

Báo cáo y học: "Tolerability and adverse events in clinical trials of celecoxib in osteoarthritis and rheumatoid arthritis: systematic review and meta-analysis of information from company clinical trial report" potx

... be made, including conditiontreated, duration of study, comparator drug, and dose. Ideallyall these would be tested by sensitivity analysis. We limited our analyses to comparator and dose to ... There were also possible benefits relating to loss ofblood in the lower gastrointestinal tract, with fewer patients having falls in haemoglobin or haematocrit. These results againare expected, and ... daily, mostly as twice-daily dosing. In trials of 2 to 6 weeks, 88% of the doses were200 mg daily. In trials of 12 weeks' duration, 46% of doseswere 200 mg and 46% were of 400 mg daily. In...

Báo cáo y học: "Metalloproteinase and inhibitor expression profiling of resorbing cartilage reveals pro-collagenase activation as a critical step for collagenolysis" pot

... early as day 5 of culture. Although the inhibitory bio-assay used does not discriminate between TIMPs and othermetalloproteinase inhibitors, the reduction in inhibitory activitybetween days ... the ECM in both physiology and pathology. MMPs are divided into several groups: colla-genases, gelatinases, stromelysins, membrane-type MMPs, and glycosylphosphatidylinositol-anchored enzymes [8].All ... response to pro-inflammatorycytokines in chondrocytes [27,28]; however, these studieshave been confined to investigating gene expression in iso-lated chondrocyte monolayers. Here, we have profiled...

Báo cáo y học: "Chondroitin and glucosamine sulfate in combination decrease the pro-resorptive properties of human osteoarthritis subchondral bone osteoblasts: a basic science study" pptx

... couldhave been modulated by CS and/ or GS, thereby indirectlyaffecting bone resorption activity. Such CS- and/ or GS-inde-pendent effects could explain our findings in which, althoughan increase in ... is expected to be very weak. Indeed, it hasbeen demonstrated that even a tetrasaccharide has a very lowbinding affinity toward OPG heparin domain compared with amolecule containing more saccharides ... assessment and meta-analysis. JAMA 2000,283:1469-1475.5. Richy F, Bruyere O, Ethgen O, Cucherat M, Henrotin Y, ReginsterJY: Structural and symptomatic efficacy of glucosamine and chondroitin in knee...

Báo cáo y học: " Immunity and other defenses in pea aphids, Acyrthosiphon pisum" ppt

... 17LysozymesLysozymes represent a family of enzymes that degra debacterial cell walls by hydrolyzing the 1,4-beta-linkagesbetween N-acetyl-D-glucosamine and N-acetylmuramicacid in peptidoglycan ... encoding insect cecro-pins, drosocin (and other proline-rich arthropod AMPs),diptericin (and other glycine-rich AMPs), drosomycin,metchnikowin, formicin, moricin, spingerin, gomesin,tachyplesin, ... -D-glucosamine), hydrolyzing 1,4-beta-linkages between N-acetyl-D-glucosamines. Chiti-nases and lysozymes represent a superfamily of hydro-lases, and their catalytic activities are similar. Indeed,some...

Báo cáo y học: "Chronotypology and melatonin alterations in minimal hepatic encephalopathy" pot

... 10.7 years in men and 62.8 ± 3.4 years in women. Cirrhosis etiologywas alcohol in 13 patients, HBV infection in 9, HCV infec-tion in 1, combined alcohol and HBV infection in 1 and combined ... study.Conclusion: Melatonin abnormalities occur in cirrhosis patients without clinical encephalopathy,are related to liver insufficiency severity, may influence chronotypology patterns, and certainlydeserve ... patients exhibited Morningness (DM or MM) Chronotypology.This unexpected finding may in part be explained by theopposing effects of melatonin and bright morning light in our Mediterranean population....

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