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Báo cáo y học: "Distinct signal transduction processes by IL-4 and IL-13 and influences from the Q551R variant of the human IL-4 receptor alpha chain" docx

Báo cáo y học:

Báo cáo y học: "Distinct signal transduction processes by IL-4 and IL-13 and influences from the Q551R variant of the human IL-4 receptor alpha chain" docx

... articleDistinct signal transduction processes by IL-4 and IL-13 and influences from the Q551R variant of the human IL-4 receptor alpha chainSusanne Kruse, Sandra Braun and Klaus A DeichmannUniversity Children's ... transduction processes in the IL-4/ IL-13 pathway. These findings thus provide the first evidence fordistinct roles of IL-4 and IL-13 while acting through the same IL-13 receptor. They support the idea of ... un-derstand the complex immunological processes underlying the development of these diseases. Two important regula-tors of the human immune system are the pleiotropic cy-tokines IL-4 and IL-13. They...
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Báo cáo y học: "Are bone erosions detected by magnetic resonance imaging and ultrasonography true erosions? A comparison with computed tomography in rheumatoid arthritis metacarpophalangeal joints" pptx

... erosions. Signal on radiography and CT is based on attenuation of X-rays, and bone and other calcified tissues are easily depictedbecause of markedly higher X-ray attenuation by these tissuesthan by ... radiography, the overall sensi-tivity, specificity and accuracy were 19%, 100% and 81%,respectively. For MRI, the corresponding values were 68%,96% and 89%, and for US they were 42%, 91% and 80%(Table ... to the joint and seen in twoplanes, as suggested by Szkudlarek and coworkers [31].Statistical analysisWith CT as the standard reference method, the sensitivity,specificity and accuracy of...
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Báo cáo y học: "Prior exposure to an attenuated Listeria vaccine does not reduce immunogenicity: pre-clinical assessment of the efficacy of a Listeria vaccine in the induction of immune responses against HIV" pps

... Gagprotein. The efficacy of the Lm vector was determined by ELISA to assess the generation of anti-Listerial antibodies;cellular responses were measured by HIV-Gag specific ELISpot assay. Our results ... meancompared to the sera of 6 naïve monkeys. No increaseswere observed during the course of the immunization inany monkeys (Table 1 and 2). We also screened foranti-Gag IgG responses by using ELISA ... immunogenicity studies by adopting a modified vac-cine dose and delivery regimen relying solely o n oralvaccination.Modified vaccine deliveryTwo groups of macaques, one previously exposed to the Lmdd...
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Báo cáo y học: " Extravascular lung water assessed by transpulmonary single thermodilution and postmortem gravimetry in sheep" doc

... Department of Anesthesiology, Faculty of Medicine, University of Tromsø, Tromsø, Norway2Professor, Chairman of the Department of Anesthesiology, Faculty of Medicine, University of Tromsø, Tromsø, ... the walls of the large vessels and the myocardium, and by recirculation of the indicator [8].In addition, the coefficients for calculation of EVLWIST and ITBV may vary with weight and age, ... gravimetry[4]. This underestimation increases during ALI caused by instillation of hydrochloric acid into the airways, and has beenexplained by redistribution of pulmonary blood flow away from the...
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Báo cáo y học: "Dialysis dose in acute kidney injury: no time for therapeutic nihilism – a critical appraisal of the Acute Renal Failure Trial Network study" ppt

... reduction of approximately 15% in the intensive dosegroup and of approximately 9% in the less-intensive group.Furthermore, although the dose delivery was relatively high,still only 89% and 95% of the ... first studyassessing the effect of the chronic hemodialysis dose on the outcome of ESRD patients [2]. Unfortunately, the results from this study were misinterpreted by the study investigators, whomade ... kidney injury and possibly reduce the likelihood of renal recovery.Continuous renal replacement therapyMore than 95% of all treatments provided to hemody-namically unstable patients consisted of...
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Báo cáo y học: "A first city-wide early defibrillation project in a German city: 5-year results of the Bochum against sudden cardiac arrest study" potx

... firstresponders are displayed, and they can be immediatelycalled in case of an emergency. The reported data are a descriptive report of the imple-mentation and clinical outcomes of an early defibrillationprogramme ... preceded by the observed collapse of the subjects, whereas two adminis-trations were preceded by an unobserved collapse. In all12 cases, the AEDs were used prior to the arrival of the emergency physician ... directlyavailable at the emergency site (< 100 metres); it was used by laymen onsite, and AED shock delivery led to success-ful conversion into a palpable rhythm. In the case of the other...
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Tài liệu Báo cáo khoa học: 1. Signal Transduction 1.1 Integration of Metabolism and Survival pdf

Tài liệu Báo cáo khoa học: 1. Signal Transduction 1.1 Integration of Metabolism and Survival pdf

... network (TGN) and the plasma mem-brane suggesting that they may be involved in the secretory/endo-cytic pathways. STAMP1 is expressed exclusively in the epithelialcells of the prostate and its expression ... shortly after in the cilia of olfactorysensory neurons. In these sensory systems CNG channels medi-ate sensory transduction by conducting cationic currents carriedprimarily by sodium and calcium ... stimulation of epithelial-to-mesenchymaltransition of tumor cells, stimulation of angiogenesis and suppression of the immune system. We are currently delineating the signaling pathways involved in the...
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Báo cáo khoa học: Organizing signal transduction through A-kinase anchoring proteins (AKAPs) docx

Báo cáo khoa học: Organizing signal transduction through A-kinase anchoring proteins (AKAPs) docx

... levels arekept low by the action of prolyl hydroxylases (PHD),a family of oxygen-sensitive dioxygenases [28].Hydroxylated proline residues in HIF-1a constitute abinding site for the von Hippel–Lindau ... organization of responses to second messengers. The examples wehave used illustrate the utility of AKAPs as a family of cofactors that uphold the molecular organization of enzyme cascades and the fidelity ... permits the robust phosphorylation of AMPA receptors by PKA atkey residues that enhance the flow of ions through the channel [11–13]. This effect is counterbalanced by AKAP150-targeting of the calcium...
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Báo cáo Y học: Distinct parts of minichromosome maintenance protein 2 associate with histone H3/H4 and RNA polymerase II holoenzyme pptx

Báo cáo Y học: Distinct parts of minichromosome maintenance protein 2 associate with histone H3/H4 and RNA polymerase II holoenzyme pptx

... possibility by analyzing the binding of the MCM2 mutants to histone H3/H4. The flow-throughfractions of the GST-TFIIS columns were loaded sequen-tially on BSA-agarose and H3/H4-agarose columns. The resins ... D, E, F, and H [1] and other proteins have beenisolated from yeast, mammalian and amphibian cells [2–8].TheyarereferredtoaspolIIÔholoenzymeÕ. Some of the components of pol II holoenzyme make ... extensively and eluted with 1MNaCl. 0.33% of the Flowthrough (FT) and 40% of each final wash (W) and eluate (E)fractions were analyzed by Western blotting with the indicated anti-bodies. The figure...
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Báo cáo y học:

Báo cáo y học: "Distinct synovial immunopathology in Behçet disease and psoriatic arthritis" pot

... a prominent role of PMN in the disease process and may suggest some degree of similarity between the patho-physiology of the synovitis and skin reactions such as the pathergy test in BD. In ... availability of biopsy sampling by needle arthroscopy to revisit in detail the synovial immunopa-thology of BD. None of the arthroscopies, performed primarilyfor diagnostic and/ or therapeutical ... and PsA. There were no signs of neutrophilic orcytoclastic vasculitis.Accumulation of T lymphocytes in Behçet disease synovitisIn the analysis of the lymphocytic infiltration (Table 1), the...
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