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Báo cáo y học: "Using single nucleotide polymorphisms as a means to understanding the pathophysiology of asthma" pps

Báo cáo y học:

Báo cáo y học: "Using single nucleotide polymorphisms as a means to understanding the pathophysiology of asthma" pps

... emphasis away fromlinkage analysis and microsatellite markers towards SNPgenotyping and different analytical strategies based onassociation and haplotype analysis [31–34]. Associationanalyses ... pharmaceutical industry [4].Asthma is a genetically complex disease that is associatedwith the familial syndrome of atopy and increased levels of total serum IgE [5,6]. Asthma and atopy are also closelyassociated ... Deichmann KA, Izuhara I, Mao I, Adra CN, Hopkin JM:Atopy and asthma: genetic variants of IL-4 and IL-13 sig-nalling. Immunol Today 2000, 21:60–64.105.Takabayashi A, Ihara K, Sasaki Y, Suzuki Y, ...
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Báo cáo y học:

Báo cáo y học: " Using an Ishikawa diagram as a tool to assist memory and retrieval of relevant medical cases from the medical literature" ppt

... Medical Case Reports haspublished the case of a 22-year-old lactating womanwho presented with four months of amenorrhea asso-ciated with signs of virilization. The patient was diag-nosed as having ... For example, ‘chemotherapy andradiotherapy’ are indicated in the branch of the ‘fishbone’that shows the cause of ovarian failure, a potential causefor secon dary a menorrhea/oligomenorrhea (Figure ... Bhansali A, Shanmugasundar G, Walia R, Santosh R, Dutta P: Acuteabdomen and hypothyroidism. BMJ Case Reports 2009.14. Srikantha M, Butterworth R: Pharmacological hyperprolactinaemia. BMJCase...
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Báo cáo y học: "NGR1 single nucleotide polymorphisms in rheumatoid arthritis" pdf

... of the analysis was63 years (17–81 years), and 76% were female. A cohort of 171 healthy individuals matched on the basis of age, sex andorigin were used as a healthy control group. All protocols ... the classification of the disease,were enrolled in the study. The 101 patients represented anethnically homogeneous cohort of Caucasian RA patients. The median (range) age of the patients at time ... revealed that the dis-ease-associated polymorphic alleles usually common in Cau-casians (over 8% prevalence) are absent or only extremelyrarely present in the Japanese population [8]. Our data...
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Báo cáo y học:

Báo cáo y học: "TLR7 single-nucleotide polymorphisms in the 3’ untranslated region and intron 2 independently contribute to systemic lupus erythematosus in Japanese women: a case-control association study" ppsx

... Furukawa2, Yuya Kondo3, Satoshi Ito3,4, Taichi Hayashi3, Makio Kusaoi5, Isao Matsumoto3,Shigeto Tohma2, Yoshinari Takasaki5, Hiroshi Hashimoto6, Takayuki Sumida3and Naoyuki ... T, Graham RR, Hom G, Takasaki Y, Hashimoto H, Behrens TW, Sumida T, Tsuchiya N: Role of STAT4 polymorphisms in systemic lupus erythematosus in a Japanesepopulation: a case-control association ... on the basis of the HapMap Phase II JPT (Japanese in Tokyo)data obtained from the HapMap database [9] with the cri-teria of minor allele frequency >0.1 and an r2threshold of 0.9. Genotyping...
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Báo cáo y học:

Báo cáo y học: "Soluble IL-18 receptor complex: a new star in the firmament of rheumatoid arthritis diagnosis" pptx

... plexity of the infl ammatory process: the shedding of membrane IL-18Rα as a marker of enhanced proteolytic activity; the activation and release of IL-18 by the infl ammasome as a marker of innate ... Matsunaga K, Sakazaki Y, Sawada M, Oda H, Takenaka S-I, Imaoka H, Kinoshita T, Honda S, Ida S, Fukuda T -A, Aizawa H: Soluble interleukin-18 receptor complex is a novel biomarker in rheumatoid ... remains to be determined whether they can be used as biomarkers in a clinical setting. IL-18 is a member of the IL-1 cytokine superfamily and plays a key role in the regulation of immunity and...
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Báo cáo y học: " Epinephrine kinetics in septic shock - a means to understand variable catecholamine efficiency" doc

... antioxidantcapacity [17]. Unfortunately, Abboud and colleagues did notreport any of these measurements, and thus the impact of oxidative or nitrosative stress on the catecholamine clearanceremains ... Inaddition, other authors have emphasized that the sepsis-related enhanced formation of nitric oxide and the superoxideradical O2-accelerates catecholamine deactivation due to formation of ... line with the data by Wilkie andcolleagues [3], although it must be underscored that the latter found an increased rather than a reduced plasmaepinephrine clearance in older and slightly lighter...
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báo cáo khoa học:

báo cáo khoa học: "RRM1 single nucleotide polymorphism -37C®A correlates with progression-free survival in NSCLC patients after gemcitabine-based chemotherapy" potx

... cycle of che-motherapy were included in the toxicity analysis. Hema-tological toxicity grade ≥ 2 was observed in 22 patients,and grade 3/4 wa s seen in 12 patients. Hepatotoxicitygrade ≥ 2 was ... histology, and o ther baselinecharacteristics were evaluated by logistic regression. Sur-vival was calculated by Kaplan-Meier method, and the log-rank test was used to determine the level of ... efficacy of gemcitabine-based chemotherapy. To test this, venous blood was col-lected before chemotherapy and gene expression wasanalyzed, but no association was found between RRM1mRNA expression...
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Báo cáo y học:

Báo cáo y học: "Latent Membrane Protein 1 as a molecular adjuvant for single-cycle lentiviral vaccines" pot

... LMP1-CD40 induces increased secretion of inflammatory cytokines and b-chemokines.Humaninflammatory cytokine quantitation was performed by cytometric bead array (CBA). Cytokine concentrations from three ... withLMP1 and LMP1-CD40 adjuvanted virus. Human inflammatory cytokinequantitation was performed from the culture supernatants by cytometricbead array (CBA). P values are shown for any statistically ... macaque DCs and macrophagesWe next examined the secre tion of various humaninflammatory cytokines by virus-infected DCs ormacrophages. Inflammatory cytokine assays were per-formed by cytometric...
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Báo cáo y học:

Báo cáo y học: " Self-reported sickness absence as a risk marker of future disability pension. Prospective findings from the DWECS/DREAM study 1990-2004"

... increase in absence days/yr. A 10-day increase in ab-sence days per annum (scale score ranging from 0-220 days/yr) yielded an increase in disability pension risk of approximately 35% (Cochran-Armitage ... Study (DWECS) and the national register on social transfer payments (DREAM). DREAM is a register based on data from the Danish Ministry of Employment, the Ministry of Social Affairs and the ... numbers of younger disability pension recipients are a particular problem as they may be beneficiaries for decades: An upper cut-off point of 45 years of ages was chosen to ensure a study population...
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Tài liệu Báo cáo khoa học:

Tài liệu Báo cáo khoa học: "Using an Annotated Corpus as a Stochastic Grammar" ppt

... that the probability of the parse of a equals 1/3, and the probability of the parse of ab equals 4/9. The parse of a can exhaustively be generated by applying rule (2), while the parse of ... language, .almost every input string of reasonable length gets an unmanageably large number of different analyses. Since most of these analyses are not perceived as plausible by a human language ... of times that parse occurred normalized with respect to N. We can estimate a probability as accurately as we want by choosing Nas large as we want, since according to the Strong Law of Large...
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