... effi-cacy, and the inhibition of inflammatory cytokines and neutrophilia in the rat AIA model with CP-690,550(Tables 1 and 2, Figures 1 and 2). Increases in arthritis,inflammatory cytokines and ... MJS, and MLB carried out the in vivo and in vitro studies. MIJ carried out some of the in vitro assays and helped write the manuscript. XL helped coordinate the in vitro assays and editing of the ... Morris2AbstractBackground: The Janus kinase (JAK) family of tyrosine kinases inclu des JAK1, JAK2, JAK3 and TYK2, and is requiredfor signaling through Type I and Type II cytokine receptors. CP-690,550 is a potent and...