Báo cáo y học: " Regional differences in the pattern of airway remodeling following chronic allergen exposure in mice" pptx

... quantify-ing airway remodeling throughout the tracheobronchialtree in animal models of allergic airway disease.It is our hypothesis that quantifying the extent of severalindices of airway remodeling ... remode-ling in mice is the first systematic airway remodeling anal-ysis of the tracheobronchial tree following chronic allergen exposure. These findings are important in dem-onstrating that insults ... regional differences in the pat-tern of airway remodeling occur in the tracheobronchialtree of mice following chronic allergen exposure. Ourmorphometric methods for quantifying airway remode-ling...

Báo cáo y học: "Regional differences in dosage compensation on the chicken Z chromosome" ppt

... might influence the clustering of dosagecompensation in the MHM valley is the evolutionary history of this segment. The sex chromosomes of birds andmonotremes may have common origins, since the ... complete X-inactivation and contains SOX3, the nearest X homologue of the Y- linked testis-determining gene SRY [1,30-37]. If the MHM valley represents the oldest part of the Z chromosome,then it ... chromo-some of the platypus contains genes in common with the Zchromosome of birds [28,29]. Indeed, homologues of 65% of MHM valley genes and 27% of peak genes are found on the platypus sex chromosome...

Báo cáo y học: " Full genome comparison and characterization of avian H10 viruses with different pathogenicity in Mink (Mustela vison) reveals genetic and functional differences in the non-structural gene" pot

... of interferon regulatory factor 3 is inhibited by the influenza A virus NS1 protein. Journal Of Virology 2000, 74:7989-7996.58. Min JY, Krug RM: The primary function of RNA binding by the influenza ... Our study also showed that there are no genetic differences in receptor specificity or the cleavability of the haemagglutinin proteins of these viruses regardless of whether they are of low ... pathogenicity in mink. In poly I:C stimulated mink lung cells the NS1 protein of influenza A virus showing high pathogenicity in mink downregulated the type I interferon promoter activity to a greater...

Báo cáo y học: "Regional differences in prediction models of lung function in Germany" ppsx

... Technology and by the State of Bavaria. The work is part of the Community Medicine Research net (CMR) of the Univer-sity of Greifswald, Germany, which is funded by the Federal Ministry of Educa-tion ... use of medication influencing lung function in the KORA study. However, the effect of diabetes in the SHIP study disappeared when the analysis was restrictedto the same age group as in the other ... 95% of the variabilityexplained by our regression models. This was true exceptfor in the case of the ratio of FEV1 to FVC, where ourregression models could explain only a very small part of the...

Báo cáo y học: " Egr-1 inhibits the expression of extracellular matrix genes in chondrocytes by TNF-induced MEK/ERK signalling" ppsx

... TNF-activatedNFB-DNA binding activity. The regulation of NFB-DNAbinding in primary cells can therefore be explained by the non-specific effect of DMSO on NFB activation. In the present study we determined ... cate-gorized by the molecular function of their protein products intocategories that included hyaluronic acid binding activity(including Agc1 and Hapln1) and proteinase activity (includingMmp-9 ... drafting and editing of the manuscript,and preparation of the figures. SMB was involved with the design and coordination of the study. AL was involved with the design and coordination of the...

Báo cáo y học: "Tandem repeats modify the structure of human genes hosted in segmental duplications" docx

... manually analyzed all these 40 modifications in order to verify the effect of the repeats on the resulting pro-teins. In the majority of cases, the reading frame of the origi-nal protein is ... retention of repeats that can significantly diversify the sequence of the encoded proteins.Fifty percent of variable ITRs modify protein sequences In agreement with an active role in modifying proteinsequences, ... 2).Often these modifications occur in polymorphic human pro-teins, such as the keratin-associated proteins, the VCX /Y pro-teins, the nuclear pore interacting proteins, and the prostate-ovary-testis-endometrium...

Báo cáo y học: "DNA transposons and the role of recombination in mutation accumulation in Daphnia pulex" pdf

... homo-zygosity of deleterious mutations may explain the repeated success of asexuals in nature [32]. Whereasany new insertions in a sexually recombining genomecan become homozygous, asexuals carry only ... Coordinationinfrastructure for the DGC is provided by The Center for Genomics andBioinformatics at Indiana University, which is supported in part by the METACytInitiative of Indiana University, ... of loss when outcrossing. Concurrently,redistribution of heterozygous copies after sex wouldresult in homozygosity 25% of the time in the case of selfing, which would dramatically re duce the...

Báo cáo y học: "Ischemic preconditioning reduces the severity of ischemia-reperfusion injury of peripheral nerve in rat" pptx

... play an essen-tial role in reducing the severity of the I/R injury byinhibiting neutrophil adhesion in postcapillary venulesand by decreasing microvascular constriction [20]. In ourstudy, ... at the 7 and 14 day reperfusion time-points. I/Rinjury of sciatic nerve has been shown to increase proin-lammatory cytokines which are primarly responsibledemyelinization after reperfusion in ... similiar.However, the protective effects of acute preconditioningare protein synthesis independent, while the effects of delayed preconditioning require protein synthesis. Adap-tational responses to I/R injury...

Báo cáo y học: " Statin pretreatment diminishes the levels of myocardial ischemia markers not only in CAB" ppsx

... of the potencial beneficial effects of statins in cardiac surgery interventions.List of abbreviationsCABG: Coronary artery bypass graft; CPB: Cardiopulmonary bypass; CPK:Creatine phosphokinase.Authors’ ... reduction of early and lateadverse events. The anti-inflammatory action of statins,as we demonstrated [2], its pleiotropic effects and the capacity of reduction of myocardial biomarkers, are the reasons ... phosphokinase.Authors’ contributions The authors read and approved the final manuscript.Competing interests The authors declare that they have no competing interests.Received: 12 November 2010...

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