Báo cáo y học: " Expression of transforming growth factor- in chronic idiopathic cough" pdf
Báo cáo y học: " Expression of transforming growth factor- in chronic idiopathic cough" pdf
... These indicate that there is anincreased amount of TGF expressed in the airways thatcould be involved in the airway wall remodelling of chronic cough. This is supported by the findings of a ... in BALF.TGF-1 protein expression in bronchial biopsies In view of the increase in TGF-1 levels in BALF from chronic cough patients, we next performed immunohisto-chemistry in the biopsy ... remodelling and of peripheral neural plasticity in chronic cough, we havemeasured in bronchoalveolar lavage fluid the levels of growth factors, such as transforming growth factor- (TGF), which may...
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Báo cáo y học: "Activation of transforming growth factor-β1 and early atherosclerosis in systemic lupus erythematosus" pptx
... activation index: an in vitro measure of the in vivo efficiency of TGF-β1 activationTo examine the ability of SLE patients and control individualsto activate TGF-β1, a ratio of levels of TGF-β1 ... con-trol individuals on entry into the study. A study of the variation in TGF-β1 AI over time and with disease activity and treatment in SLE patients is beyond the scope of the present study.Apoptosis ... TGF-β1 in an in vitro assay that utilizesthe physiological activation of latent TGF-β1 that occurs nor-mally during blood clotting. The activation of TGF-β1 duringclotting is complex, being...
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Báo cáo khoa học: Control of transforming growth factor b signal transduction by small GTPases pot
... implies theinvolvement of non-Smad pathways, in certain cases itwas found that the Smad pathway may also play arole in the early activation of Rho proteins by TGFb.By studying the signaling properties ... recycling. The cycling of Rab5 between the GTP and GDP forms may in uence the length and intensity of TGFb ⁄ activin signalingcascades by regulating TGFb–activin type I ⁄ II receptor trafficking ... the hydrolysis of GTP. Completion of the Ran cycle is shown in the middle for Smad3because the role of Ran has only been analyzed in detail in the case of Smad3. Cytoplasmic Ran–GDP (grey symbol)...
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Báo cáo Y học: Expression of uncoupling protein-3 in subsarcolemmal and intermyofibrillar mitochondria of various mouse muscle types and its modulation by fasting docx
... Flandin, Jean-Paul Giacobino and Patrick MuzzinDepartment of Medical Biochemistry, Faculty of Medicine, University of Geneva, SwitzerlandUncoupling protein-3 (UCP3) is a mitochondrial inner-membrane ... acomparative study in mice of UCP3 protein expression in SS and IMF mitochondria of various muscle types. We alsoexamined UCP3 protein expression in the two mitochon-dria populations of fed and fasted ... obtained on the same gel.The density of UCP3 protein (i.e. the intensity of thesignal expressed per mg of proteins) was similar in the SSmitochondria of the two glycolytic muscles, tibialis anteriorand...
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Báo cáo y học: "Expression of inflammatory host genes in Chlamydia trachomatis-infected human monocytes" docx
... themajority of EBs being internalized. This corresponds to ourfinding of an overall normalizing gene expression comparedwith mock-infected cells. Finally, day 7 reflects a definite per-sistent infective ... indi-cating that expression of these genes in Chlamydia-infectedmonocytes contributes to an apparently hampered elimination of the pathogen.Sustained expression over the course of 7 days of the ... day 7 represents persistent infection. BCA, B-cell-attracting chemokine; IL, interleukin; IP, interferon inducible protein; MCP, monocyte chemotactic protein; MIG, monokine induced by gamma-interferon;...
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Báo cáo y học: "Action of fibroblast growth factor-2 on the intervertebral disc" docx
... understanding of the complex interplay of growth factors, cytokines, and enzymes in the IVD. To our knowledge,this is the first study that demonstrates the pathophysiologiceffects of FGF2 in spine ... increases the expression of cartilage-degrading enzymes by bovine intervertebral disc cellsFibroblast growth factor 2 increases the expression of cartilage-degrading enzymes by bovine intervertebral disc ... proliferation in bovine spine discs [52], it failed to increaseECM synthesis in parallel in our study, resulting in clustering of cells with little surrounding ECM – a hallmark of arthriticcartilage.Further,...
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Báo cáo y học: "Role of fibroblast growth factor 8 (FGF8) in animal models of osteoarthritis" doc
... chondrocytes. These studies suggest that the injury of synovia induces the expression of FGF8 in the joint, and thismay promote degradation of cartilage via a paracrine system.The bone weight of ... using diaminobenzidine (brown) and counter stained with hematoxylin (blue). Very weak stain-ing of FGF8 was observed in a few synovial cells, but not in other tis-sues in normal knee joints. ... degradation of the ECM. The participation of synovial inflammation in the pro-gression of cartilage changes at the clinical stage of OA isbecoming increasingly obvious [1]. A number of clinical...
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Báo cáo y học: "Expression of tumor necrosis factor-alpha converting enzyme and matrix metalloproteinase-3 in proliferated synovium in a patient with synovitis-acne-pustulosis-hyperostosis-osteitis syndrome: a case report" doc
... pathological events in RA. These findings indicatethat synovitis and the processing of TNF-a by TACE arevery important aspects in the pathogenesis of SAPHOsyndrome. However, detailed information on ... punctureyielded 20 ml of yellow cloudy joint fluid, but cultures forbacteria were negative. At the time, mild, dull lower backpain was still continuing but no other joint pain, including in the ... positive synovial cells of the superficial lining layer, whereas MMP-3 was expressed in CD68 negative synovial cells of the deep lining layer(Figure 1e-h). Primary antibodies used for these analyseswere...
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Báo cáo y học: "Role of epidermal growth factor receptor activation in regulating mucin synthesis" pdf
... caused expression of the MUC5AC mucin (a predominant airwaymucin) gene. Interaction of EGFR with its ligands led toEGFR tyrosine kinase phosphorylation, and a selectiveEGFR tyrosine kinase inhibitor ... virus-induced goblet-cell metaplasia in pathogen-free rats, developing mucin-containing cellsdid not incorporate [3H]thymidine, suggesting that cellmitosis was not involved in synthesis of mucin ... theairways [26], and the infiltrating neutrophils expressedTNF-α. An interleukin-8-blocking antibody inhibits inter-leukin-13-induced neutrophil recruitment and mucin pro-duction. Thus, interleukin-13...
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