... inhibitor-insensitive proteases of insect pests. Trends Biotechnol. 14, 33 1 33 3. 32 Michaud, D. (1997). Avoiding protease-mediated resistance to herbivorouspests. Trends Biotechnol. 15, 4–6. 33 Murdock, ... 9C), and the promoter associ-ated with the coding sequence (which affects the quantity and location of the Cry protein). In 1999, 30 percent of the cultivated area in the USAconsisted of transgenic ... 1996 of lepidopteran-insect-resistant cotton in the USA [7]. The expression of an insecticidal protein in plants presents many advan-tages over the exogenous application of chemicals. The “toxin,”...