... Kamihira S, Yamada Y, Hirakata Y, Tomonaga M, Sugahara K, Hay-ashi T, Dateki N, Harasawa H, Nakayama K: Aberrant expression of caspase cascade regulatory genes in adult Tcell leukaemia:survivin ... cytoplasm. Both pathways induceexpression of apoptosis genes and activation of the cas-pase cascade, resulting in DNA fragmentation. The apop-tosis signals are abrogated by the family of apoptosis-inhibiting ... the pathogenesis of exper-imental arthritis [13,14].Survivin is a 142-amino-acid protein that belongs to the IAPfamily, and it inhibits the activity of caspase 3, caspase 7,and caspase 9,...